hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_15098.1
Complex Portal: CPX-24319
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RAN | GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein) | 5 | UniProt NCBI |
| RGPD2 | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | 3 | UniProt NCBI |
| NUTF2 | Nuclear transport factor 2 (NTF-2) (Placental protein 15) (PP15) | 5 | UniProt NCBI |
| NEMP2 | Nuclear envelope integral membrane protein 2 | 2 | UniProt NCBI |
| TAGLN | Transgelin (22 kDa actin-binding protein) (Protein WS3-10) (Smooth muscle protein 22-alpha) (SM22-alpha) | 4 | UniProt NCBI |
| RGPD4 | RanBP2-like and GRIP domain-containing protein 4 | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005643 | 0.000719028723342 | 0.666666666667 | RGPD2 RGPD4 RAN NUTF2 | nuclear pore |
| GO:0006606 | 0.00179501440744 | 0.666666666667 | RGPD2 RGPD4 RAN NUTF2 | protein import into nucleus |
| GO:0051170 | 0.00217058422698 | 0.666666666667 | RGPD2 RGPD4 RAN NUTF2 | import into nucleus |
| GO:0005635 | 0.00228495154828 | 0.833333333333 | RGPD2 RGPD4 NEMP2 RAN NUTF2 | nuclear envelope |
| GO:0034504 | 0.0379514736875 | 0.666666666667 | RGPD2 RGPD4 RAN NUTF2 | protein localization to nucleus |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RAN | RGPD4 | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| RAN | RGPD2 | 0.995 | 0.214 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RAN | NEMP2 | 0.988 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RAN | NUTF2 | 0.986 | 0.228 |
mixed_interface
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction treiber_WMM |
| NUTF2 | TAGLN | 0.898 | 0.116 | Guru bioplex3_WMM fraction | |
| NUTF2 | NEMP2 | 0.372 |
mutually_exclusive (P62826)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| RGPD2 | NEMP2 | 0.35 | bioplex_WMM bioplex3_WMM WMM_only | ||
| RGPD2 | NUTF2 | 0.266 | 0.096 | bioplex_WMM bioplex3_WMM WMM_only | |
| RGPD4 | NEMP2 | 0.214 | bioplex3_WMM WMM_only | ||
| RGPD2 | RGPD4 | 0.131 | bioplex3_WMM WMM_only | ||
| NUTF2 | RGPD4 | 0.081 | bioplex3_WMM WMM_only |
Related Complexes