hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_15100.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DNAJC12 | DnaJ homolog subfamily C member 12 (J domain-containing protein 1) | 4 | UniProt NCBI |
| TPH2 | Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) (Neuronal tryptophan hydroxylase) (Tryptophan 5-monooxygenase 2) | 5 | UniProt NCBI |
| ERI2 | ERI1 exoribonuclease 2 (EC 3.1.-.-) (Exonuclease domain-containing protein 1) | 4 | UniProt NCBI |
| TPH1 | Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-209931 | 6.15041976665e-05 | 0.5 | TPH2 TPH1 | Serotonin and melatonin biosynthesis |
| WP:WP4220 | 7.14678770193e-05 | 0.5 | TPH2 TPH1 | Neurotransmitter disorders |
| REAC:R-HSA-209776 | 0.000563428413222 | 0.5 | TPH2 TPH1 | Metabolism of amine-derived hormones |
| WP:WP465 | 0.00070344077777 | 0.5 | TPH2 TPH1 | Tryptophan metabolism |
| KEGG:00790 | 0.000750887219606 | 0.5 | TPH2 TPH1 | Folate biosynthesis |
| WP:WP4698 | 0.000894348084449 | 0.5 | TPH2 TPH1 | Vitamin D sensitive calcium signaling in depression |
| KEGG:00380 | 0.0013205961284 | 0.5 | TPH2 TPH1 | Tryptophan metabolism |
| GO:0004510 | 0.0028092043205 | 0.5 | TPH2 TPH1 | tryptophan 5-monooxygenase activity |
| GO:0016714 | 0.00842684400117 | 0.5 | TPH2 TPH1 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen |
| KEGG:04726 | 0.00867836513934 | 0.5 | TPH2 TPH1 | Serotonergic synapse |
| WP:WP706 | 0.0183400443465 | 0.5 | TPH2 TPH1 | Sudden infant death syndrome SIDS susceptibility pathways |
| HPA:0140141 | 0.0212163885994 | 0.25 | TPH2 | dorsal raphe; neuronal projections[>=Low] |
| HPA:0140142 | 0.0212163885994 | 0.25 | TPH2 | dorsal raphe; neuronal projections[>=Medium] |
| HPA:0140143 | 0.0212163885994 | 0.25 | TPH2 | dorsal raphe; neuronal projections[High] |
| HPA:0140151 | 0.0212163885994 | 0.25 | TPH2 | dorsal raphe; synapses[>=Low] |
| HPA:0140152 | 0.0212163885994 | 0.25 | TPH2 | dorsal raphe; synapses[>=Medium] |
| HPA:0140153 | 0.0212163885994 | 0.25 | TPH2 | dorsal raphe; synapses[High] |
| HPA:0140133 | 0.0212163885994 | 0.25 | TPH2 | dorsal raphe; neuronal cells[High] |
| WP:WP3594 | 0.03162086928 | 0.5 | TPH2 TPH1 | Circadian rhythm genes |
| HPA:0140131 | 0.0424284218432 | 0.25 | TPH2 | dorsal raphe; neuronal cells[>=Low] |
| HPA:0140000 | 0.0424284218432 | 0.25 | TPH2 | dorsal raphe |
| HPA:0140132 | 0.0424284218432 | 0.25 | TPH2 | dorsal raphe; neuronal cells[>=Medium] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TPH1 | DNAJC12 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TPH2 | TPH1 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TPH2 | DNAJC12 | 0.946 | 0.084 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| DNAJC12 | ERI2 | 0.887 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| DNAJC12 | huMAP3_03383.1 huMAP3_03709.1 huMAP3_05004.1 huMAP3_09937.1 huMAP3_10288.1 huMAP3_15100.1 |
| TPH2 | huMAP3_00840.1 huMAP3_15100.1 |
| ERI2 | huMAP3_15100.1 |
| TPH1 | huMAP3_00840.1 huMAP3_15100.1 |