hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_15114.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RTL9 | Retrotransposon Gag-like protein 9 (Retrotransposon gag domain-containing protein 1) (Tumor antigen BJ-HCC-23) | 2 | UniProt NCBI |
| UGT1A8 | UDP-glucuronosyltransferase 1A8 (UGT1A8) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-8) (UDPGT 1-8) (UGT1*8) (UGT1-08) (UGT1.8) (UDP-glucuronosyltransferase 1-H) (UGT-1H) (UGT1H) | 5 | UniProt NCBI |
| UGT1A9 | UDP-glucuronosyltransferase 1A9 (UGT1A9) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-9) (UDPGT 1-9) (UGT1*9) (UGT1-09) (UGT1.9) (UDP-glucuronosyltransferase 1-I) (UGT-1I) (UGT1I) (lugP4) | 5 | UniProt NCBI |
| UGT1A10 | UDP-glucuronosyltransferase 1A10 (UGT1A10) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-10) (UDPGT 1-10) (UGT1*10) (UGT1-10) (UGT1.10) (UDP-glucuronosyltransferase 1-J) (UGT-1J) (UGT1J) | 5 | UniProt NCBI |
| ZFP69B | Zinc finger protein 69 homolog B (Zinc finger protein 643) | 5 | UniProt NCBI |
| CIMIP4 | Ciliary microtubule inner protein 4 (Testis-expressed protein 33) | 4 | UniProt NCBI |
| HAPLN3 | Hyaluronan and proteoglycan link protein 3 | 3 | UniProt NCBI |
| UGT1A7 | UDP-glucuronosyltransferase 1A7 (UGT1A7) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-7) (UDPGT 1-7) (UGT1*7) (UGT1-07) (UGT1.7) (UDP-glucuronosyltransferase 1-G) (UGT-1G) (UGT1G) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0051552 | 1.84188417064e-09 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | flavone metabolic process |
| WP:WP698 | 1.02534731012e-08 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | Glucuronidation |
| KEGG:00053 | 1.32874699705e-08 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | Ascorbate and aldarate metabolism |
| REAC:R-HSA-156588 | 1.42273501904e-08 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | Glucuronidation |
| KEGG:00040 | 2.29632234234e-08 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | Pentose and glucuronate interconversions |
| GO:0009812 | 6.44235965654e-08 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | flavonoid metabolic process |
| KEGG:00860 | 7.41508346857e-08 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | Porphyrin metabolism |
| KEGG:00140 | 1.65353041647e-07 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | Steroid hormone biosynthesis |
| KEGG:00830 | 4.51056884427e-07 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | Retinol metabolism |
| KEGG:05204 | 5.28302328322e-07 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | Chemical carcinogenesis - DNA adducts |
| KEGG:00982 | 5.7044125919e-07 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | Drug metabolism - cytochrome P450 |
| KEGG:04976 | 7.64609869279e-07 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | Bile secretion |
| KEGG:00980 | 8.20037755687e-07 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | Metabolism of xenobiotics by cytochrome P450 |
| WP:WP1604 | 1.17658221023e-06 | 0.375 | UGT1A9 UGT1A8 UGT1A10 | Codeine and morphine metabolism |
| KEGG:00983 | 1.37860509436e-06 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | Drug metabolism - other enzymes |
| GO:0052695 | 1.8396911621e-06 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | cellular glucuronidation |
| GO:0019585 | 2.50812007172e-06 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | glucuronate metabolic process |
| GO:0006063 | 2.50812007172e-06 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | uronic acid metabolic process |
| REAC:R-HSA-156580 | 1.21911025179e-05 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | Phase II - Conjugation of compounds |
| REAC:R-HSA-9748784 | 1.28215875769e-05 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | Drug ADME |
| WP:WP5224 | 1.57144682951e-05 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | 2q37 copy number variation syndrome |
| GO:0015020 | 1.94862705925e-05 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | glucuronosyltransferase activity |
| GO:0052696 | 2.15253635486e-05 | 0.375 | UGT1A9 UGT1A8 UGT1A7 | flavonoid glucuronidation |
| KEGG:01240 | 2.27576058044e-05 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | Biosynthesis of cofactors |
| KEGG:05207 | 4.9910919986e-05 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | Chemical carcinogenesis - receptor activation |
| REAC:R-HSA-9749641 | 9.23525641109e-05 | 0.375 | UGT1A9 UGT1A8 UGT1A7 | Aspirin ADME |
| GO:0052697 | 0.00010757157937 | 0.375 | UGT1A9 UGT1A8 UGT1A7 | xenobiotic glucuronidation |
| GO:0001889 | 0.000120770447162 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | liver development |
| GO:0061008 | 0.000134949126163 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | hepaticobiliary system development |
| REAC:R-HSA-211859 | 0.000214510762493 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | Biological oxidations |
| GO:0042440 | 0.000455567453272 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | pigment metabolic process |
| WP:WP229 | 0.00131250845457 | 0.25 | UGT1A9 UGT1A10 | Irinotecan pathway |
| GO:0001972 | 0.00153551162834 | 0.375 | UGT1A9 UGT1A8 UGT1A7 | retinoic acid binding |
| WP:WP691 | 0.00216982178847 | 0.25 | UGT1A10 UGT1A8 | Tamoxifen metabolism |
| WP:WP702 | 0.00380723698087 | 0.375 | UGT1A9 UGT1A7 UGT1A10 | Metapathway biotransformation Phase I and II |
| GO:0006805 | 0.00402583472149 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | xenobiotic metabolic process |
| WP:WP5276 | 0.00499769201238 | 0.25 | UGT1A10 UGT1A8 | Estrogen metabolism |
| GO:0019840 | 0.00712601113833 | 0.375 | UGT1A9 UGT1A8 UGT1A7 | isoprenoid binding |
| GO:0005501 | 0.00712601113833 | 0.375 | UGT1A9 UGT1A8 UGT1A7 | retinoid binding |
| GO:0071466 | 0.0100133115528 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | cellular response to xenobiotic stimulus |
| GO:0048732 | 0.011578905434 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | gland development |
| GO:0042573 | 0.0123105223466 | 0.375 | UGT1A9 UGT1A8 UGT1A7 | retinoic acid metabolic process |
| GO:0008194 | 0.012426913615 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | UDP-glycosyltransferase activity |
| REAC:R-HSA-9753281 | 0.0128161014463 | 0.25 | UGT1A9 UGT1A10 | Paracetamol ADME |
| WP:WP2873 | 0.0157805174951 | 0.25 | UGT1A9 UGT1A7 | Aryl hydrocarbon receptor pathway |
| GO:0009410 | 0.0281979257523 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | response to xenobiotic stimulus |
| TF:M09875 | 0.0282952795416 | 0.75 | UGT1A10 RTL9 UGT1A8 UGT1A7 UGT1A9 ZFP69B | Factor: BHLHA15; motif: SNAGCAGCTGG |
| GO:0016758 | 0.0433830596151 | 0.5 | UGT1A9 UGT1A7 UGT1A8 UGT1A10 | hexosyltransferase activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| UGT1A7 | UGT1A10 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RTL9 | UGT1A7 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| UGT1A7 | UGT1A9 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| UGT1A10 | UGT1A9 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RTL9 | CIMIP4 | 0.983 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| UGT1A8 | UGT1A7 | 0.972 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| RTL9 | UGT1A9 | 0.946 | bioplex3_WMM WMM_only | |
| UGT1A7 | HAPLN3 | 0.935 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| UGT1A10 | ZFP69B | 0.914 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| RTL9 | UGT1A10 | 0.415 | bioplex3_WMM WMM_only | |
| UGT1A8 | UGT1A10 | 0.415 | bioplex3_WMM WMM_only | |
| UGT1A8 | UGT1A9 | 0.415 | bioplex3_WMM WMM_only | |
| RTL9 | UGT1A8 | 0.415 | bioplex3_WMM WMM_only | |
| RTL9 | HAPLN3 | 0.356 | bioplex3_WMM WMM_only | |
| UGT1A9 | HAPLN3 | 0.22 | bioplex3_WMM WMM_only | |
| UGT1A8 | HAPLN3 | 0.042 | bioplex3_WMM WMM_only | |
| UGT1A10 | HAPLN3 | 0.041 | bioplex3_WMM WMM_only |
Related Complexes