hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_15127.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAPK8 | Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) | 5 | UniProt NCBI |
| DUSP8 | Dual specificity protein phosphatase 8 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH-5) | 5 | UniProt NCBI |
| KCTD14 | BTB/POZ domain-containing protein KCTD14 | 3 | UniProt NCBI |
| MAPK9 | Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (JNK-55) (Stress-activated protein kinase 1a) (SAPK1a) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) | 5 | UniProt NCBI |
| KCNAB3 | Voltage-gated potassium channel subunit beta-3 (EC 1.1.1.-) (K(+) channel subunit beta-3) (Kv-beta-3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3874 | 0.000616503269292 | 0.4 | MAPK8 MAPK9 | Canonical and non canonical TGF B signaling |
| REAC:R-HSA-450341 | 0.000683310775372 | 0.4 | MAPK8 MAPK9 | Activation of the AP-1 family of transcription factors |
| WP:WP382 | 0.00157746248845 | 0.6 | MAPK8 DUSP8 MAPK9 | MAPK signaling pathway |
| WP:WP3869 | 0.00175902717245 | 0.4 | MAPK8 MAPK9 | Cannabinoid receptor signaling |
| KEGG:04215 | 0.00183871829216 | 0.4 | MAPK8 MAPK9 | Apoptosis - multiple species |
| WP:WP2643 | 0.00205749802636 | 0.4 | MAPK8 MAPK9 | Nanoparticle mediated activation of receptor signaling |
| REAC:R-HSA-450321 | 0.00206313859056 | 0.4 | MAPK8 MAPK9 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| KEGG:04010 | 0.00215031496116 | 0.6 | MAPK8 DUSP8 MAPK9 | MAPK signaling pathway |
| WP:WP5406 | 0.00221546358612 | 0.4 | MAPK8 MAPK9 | 13q12 12 copy number variation |
| WP:WP4877 | 0.00254884296025 | 0.4 | MAPK8 MAPK9 | Host pathogen interaction of human coronaviruses MAPK signaling |
| WP:WP4331 | 0.00290547066497 | 0.4 | MAPK8 MAPK9 | Neovascularisation processes |
| REAC:R-HSA-2871796 | 0.00318398402781 | 0.4 | MAPK8 MAPK9 | FCERI mediated MAPK activation |
| WP:WP2203 | 0.00328532749654 | 0.4 | MAPK8 MAPK9 | Thymic stromal lymphopoietin TSLP signaling pathway |
| WP:WP4150 | 0.00328532749654 | 0.4 | MAPK8 MAPK9 | Wnt signaling in kidney disease |
| WP:WP2036 | 0.00368839425913 | 0.4 | MAPK8 MAPK9 | TNF related weak inducer of apoptosis TWEAK signaling pathway |
| KEGG:04930 | 0.00370756607295 | 0.4 | MAPK8 MAPK9 | Type II diabetes mellitus |
| WP:WP5347 | 0.00433647105223 | 0.4 | MAPK8 MAPK9 | IL 26 signaling pathways |
| WP:WP4534 | 0.00456408083355 | 0.4 | MAPK8 MAPK9 | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms |
| WP:WP4566 | 0.00479747871248 | 0.4 | MAPK8 MAPK9 | Translation inhibitors in chronically activated PDGFRA cells |
| WP:WP2637 | 0.00528162918062 | 0.4 | MAPK8 MAPK9 | Interleukin 1 IL 1 structural pathway |
| WP:WP363 | 0.00578890329638 | 0.4 | MAPK8 MAPK9 | Wnt signaling pathway |
| WP:WP2018 | 0.00605120573671 | 0.4 | MAPK8 MAPK9 | RANKL RANK signaling pathway |
| KEGG:04664 | 0.00622027886669 | 0.4 | MAPK8 MAPK9 | Fc epsilon RI signaling pathway |
| REAC:R-HSA-450282 | 0.0065872694687 | 0.4 | MAPK8 MAPK9 | MAPK targets/ Nuclear events mediated by MAP kinases |
| WP:WP195 | 0.00659312941575 | 0.4 | MAPK8 MAPK9 | IL 1 signaling pathway |
| KEGG:05133 | 0.00771708586936 | 0.4 | MAPK8 MAPK9 | Pertussis |
| WP:WP2374 | 0.0080488533074 | 0.4 | MAPK8 MAPK9 | Oncostatin M signaling pathway |
| WP:WP3865 | 0.00835727861991 | 0.4 | MAPK8 MAPK9 | Novel intracellular components of RIG I like receptor pathway |
| KEGG:04917 | 0.00852542753416 | 0.4 | MAPK8 MAPK9 | Prolactin signaling pathway |
| KEGG:04920 | 0.0088037421881 | 0.4 | MAPK8 MAPK9 | Adipocytokine signaling pathway |
| KEGG:05120 | 0.0088037421881 | 0.4 | MAPK8 MAPK9 | Epithelial cell signaling in Helicobacter pylori infection |
| KEGG:04622 | 0.00937366158534 | 0.4 | MAPK8 MAPK9 | RIG-I-like receptor signaling pathway |
| WP:WP5158 | 0.00998567643899 | 0.4 | MAPK8 MAPK9 | Urotensin II mediated signaling pathway |
| KEGG:04912 | 0.0102617382696 | 0.4 | MAPK8 MAPK9 | GnRH signaling pathway |
| WP:WP2324 | 0.010328593539 | 0.4 | MAPK8 MAPK9 | AGE RAGE pathway |
| WP:WP4538 | 0.010328593539 | 0.4 | MAPK8 MAPK9 | Regulatory circuits of the STAT3 signaling pathway |
| KEGG:04750 | 0.0105666091545 | 0.4 | MAPK8 MAPK9 | Inflammatory mediator regulation of TRP channels |
| WP:WP69 | 0.010677250915 | 0.4 | MAPK8 MAPK9 | T cell receptor signaling pathway |
| WP:WP3303 | 0.0113917769519 | 0.4 | MAPK8 MAPK9 | RAC1 PAK1 p38 MMP2 pathway |
| WP:WP4341 | 0.0113917769519 | 0.4 | MAPK8 MAPK9 | Non genomic actions of 1 25 dihydroxyvitamin D3 |
| KEGG:05212 | 0.0115077320087 | 0.4 | MAPK8 MAPK9 | Pancreatic cancer |
| KEGG:04658 | 0.012157220678 | 0.4 | MAPK8 MAPK9 | Th1 and Th2 cell differentiation |
| KEGG:04012 | 0.0128243509281 | 0.4 | MAPK8 MAPK9 | ErbB signaling pathway |
| WP:WP2037 | 0.0128896073912 | 0.4 | MAPK8 MAPK9 | Prolactin signaling pathway |
| WP:WP4216 | 0.0128896073912 | 0.4 | MAPK8 MAPK9 | Chromosomal and microsatellite instability in colorectal cancer |
| WP:WP5094 | 0.0128896073912 | 0.4 | MAPK8 MAPK9 | Orexin receptor pathway |
| KEGG:04657 | 0.0131645270498 | 0.4 | MAPK8 MAPK9 | IL-17 signaling pathway |
| KEGG:05210 | 0.0135091080522 | 0.4 | MAPK8 MAPK9 | Colorectal cancer |
| GO:0004705 | 0.0140440992017 | 0.4 | MAPK8 MAPK9 | JUN kinase activity |
| KEGG:01522 | 0.0149314441262 | 0.4 | MAPK8 MAPK9 | Endocrine resistance |
| KEGG:04914 | 0.0149314441262 | 0.4 | MAPK8 MAPK9 | Progesterone-mediated oocyte maturation |
| KEGG:05231 | 0.0152980219787 | 0.4 | MAPK8 MAPK9 | Choline metabolism in cancer |
| WP:WP5353 | 0.015731077008 | 0.4 | MAPK8 MAPK9 | A network map of Macrophage stimulating protein MSP signaling |
| KEGG:04625 | 0.0160443574347 | 0.4 | MAPK8 MAPK9 | C-type lectin receptor signaling pathway |
| WP:WP2355 | 0.0161598479529 | 0.4 | MAPK8 MAPK9 | Corticotropin releasing hormone signaling pathway |
| WP:WP23 | 0.0165943234371 | 0.4 | MAPK8 MAPK9 | B cell receptor signaling pathway |
| KEGG:04620 | 0.0168082536599 | 0.4 | MAPK8 MAPK9 | Toll-like receptor signaling pathway |
| KEGG:04933 | 0.0168082536599 | 0.4 | MAPK8 MAPK9 | AGE-RAGE signaling pathway in diabetic complications |
| KEGG:05142 | 0.0171967824754 | 0.4 | MAPK8 MAPK9 | Chagas disease |
| KEGG:04659 | 0.0179869923441 | 0.4 | MAPK8 MAPK9 | Th17 cell differentiation |
| KEGG:05145 | 0.0183886697314 | 0.4 | MAPK8 MAPK9 | Toxoplasmosis |
| WP:WP4263 | 0.0188521857166 | 0.4 | MAPK8 MAPK9 | Pancreatic adenocarcinoma pathway |
| WP:WP673 | 0.0188521857166 | 0.4 | MAPK8 MAPK9 | ErbB signaling pathway |
| WP:WP75 | 0.0197951791935 | 0.4 | MAPK8 MAPK9 | Toll like receptor signaling pathway |
| KEGG:04668 | 0.0200391528804 | 0.4 | MAPK8 MAPK9 | TNF signaling pathway |
| WP:WP231 | 0.020275205407 | 0.4 | MAPK8 MAPK9 | TNF alpha signaling pathway |
| KEGG:04137 | 0.0213229262457 | 0.4 | MAPK8 MAPK9 | Mitophagy - animal |
| KEGG:04931 | 0.0213229262457 | 0.4 | MAPK8 MAPK9 | Insulin resistance |
| KEGG:04935 | 0.0222006100833 | 0.4 | MAPK8 MAPK9 | Growth hormone synthesis, secretion and action |
| KEGG:04722 | 0.0222006100833 | 0.4 | MAPK8 MAPK9 | Neurotrophin signaling pathway |
| REAC:R-HSA-450294 | 0.0232374901507 | 0.4 | MAPK8 MAPK9 | MAP kinase activation |
| KEGG:04660 | 0.0235498516465 | 0.4 | MAPK8 MAPK9 | T cell receptor signaling pathway |
| KEGG:04071 | 0.0235498516465 | 0.4 | MAPK8 MAPK9 | Sphingolipid signaling pathway |
| KEGG:04926 | 0.0258857078716 | 0.4 | MAPK8 MAPK9 | Relaxin signaling pathway |
| KEGG:04728 | 0.0263659307172 | 0.4 | MAPK8 MAPK9 | Dopaminergic synapse |
| WP:WP5380 | 0.0264781270697 | 0.4 | MAPK8 MAPK9 | 5q35 copy number variation |
| KEGG:04068 | 0.028330266578 | 0.4 | MAPK8 MAPK9 | FoxO signaling pathway |
| REAC:R-HSA-448424 | 0.0285103583123 | 0.4 | MAPK8 MAPK9 | Interleukin-17 signaling |
| WP:WP428 | 0.0293032373139 | 0.4 | MAPK8 MAPK9 | Wnt signaling |
| WP:WP710 | 0.0293032373139 | 0.4 | MAPK8 MAPK9 | DNA damage response only ATM dependent |
| KEGG:05135 | 0.0293384756517 | 0.4 | MAPK8 MAPK9 | Yersinia infection |
| KEGG:04380 | 0.0293384756517 | 0.4 | MAPK8 MAPK9 | Osteoclast differentiation |
| WP:WP4787 | 0.0298851974032 | 0.4 | MAPK8 MAPK9 | Osteoblast differentiation and related diseases |
| KEGG:05418 | 0.0303640260346 | 0.4 | MAPK8 MAPK9 | Fluid shear stress and atherosclerosis |
| KEGG:04723 | 0.0314069031448 | 0.4 | MAPK8 MAPK9 | Retrograde endocannabinoid signaling |
| WP:WP4659 | 0.0316649111647 | 0.4 | MAPK8 MAPK9 | Gastrin signaling pathway |
| KEGG:04210 | 0.0319348346673 | 0.4 | MAPK8 MAPK9 | Apoptosis |
| KEGG:05162 | 0.0340898047114 | 0.4 | MAPK8 MAPK9 | Measles |
| KEGG:04936 | 0.0340898047114 | 0.4 | MAPK8 MAPK9 | Alcoholic liver disease |
| KEGG:05017 | 0.0346393491085 | 0.4 | MAPK8 MAPK9 | Spinocerebellar ataxia |
| KEGG:04910 | 0.0351932106204 | 0.4 | MAPK8 MAPK9 | Insulin signaling pathway |
| WP:WP3915 | 0.0373080007736 | 0.4 | MAPK8 MAPK9 | Angiopoietin like protein 8 regulatory pathway |
| WP:WP366 | 0.0406395857275 | 0.4 | MAPK8 MAPK9 | TGF beta signaling pathway |
| KEGG:04217 | 0.0415700968186 | 0.4 | MAPK8 MAPK9 | Necroptosis |
| KEGG:04530 | 0.0427854405203 | 0.4 | MAPK8 MAPK9 | Tight junction |
| KEGG:04932 | 0.0427854405203 | 0.4 | MAPK8 MAPK9 | Non-alcoholic fatty liver disease |
| WP:WP2380 | 0.0434056741534 | 0.4 | MAPK8 MAPK9 | Brain derived neurotrophic factor BDNF signaling pathway |
| WP:WP4630 | 0.0434056741534 | 0.4 | MAPK8 MAPK9 | Measles virus infection |
| KEGG:04621 | 0.0471742362289 | 0.4 | MAPK8 MAPK9 | NOD-like receptor signaling pathway |
| KEGG:05152 | 0.0471742362289 | 0.4 | MAPK8 MAPK9 | Tuberculosis |
| KEGG:05161 | 0.0484667159694 | 0.4 | MAPK8 MAPK9 | Hepatitis B |
| KEGG:04310 | 0.0497762971898 | 0.4 | MAPK8 MAPK9 | Wnt signaling pathway |
| REAC:R-HSA-168176 | 0.0499330761364 | 0.4 | MAPK8 MAPK9 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-168142 | 0.0499330761364 | 0.4 | MAPK8 MAPK9 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-975871 | 0.0499330761364 | 0.4 | MAPK8 MAPK9 | MyD88 cascade initiated on plasma membrane |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MAPK8 | MAPK9 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MAPK8 | KCNAB3 | 0.978 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MAPK8 | DUSP8 | 0.953 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MAPK8 | KCTD14 | 0.86 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| DUSP8 | KCNAB3 | 0.582 | bioplex_WMM bioplex3_WMM WMM_only | |
| DUSP8 | MAPK9 | 0.215 | bioplex_WMM bioplex3_WMM WMM_only | |
| MAPK9 | KCNAB3 | 0.188 | 0.09 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| MAPK8 | huMAP3_04092.1 huMAP3_12341.1 huMAP3_15127.1 |
| DUSP8 | huMAP3_04092.1 huMAP3_12341.1 huMAP3_15127.1 |
| KCTD14 | huMAP3_11446.1 huMAP3_13430.1 huMAP3_15127.1 |
| MAPK9 | huMAP3_04092.1 huMAP3_12341.1 huMAP3_15127.1 |
| KCNAB3 | huMAP3_07655.1 huMAP3_09251.1 huMAP3_10381.1 huMAP3_11194.1 huMAP3_13061.1 huMAP3_14401.1 huMAP3_15127.1 |