hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_15138.1
Complex Portal: CPX-20116
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PEX7 | Peroxisomal targeting signal 2 receptor (PTS2 receptor) (Peroxin-7) | 5 | UniProt NCBI |
| NANOS1 | Nanos homolog 1 (NOS-1) (EC_Rep1a) | 5 | UniProt NCBI |
| PHYH | Phytanoyl-CoA dioxygenase, peroxisomal (EC 1.14.11.18) (Phytanic acid oxidase) (Phytanoyl-CoA alpha-hydroxylase) (PhyH) | 5 | UniProt NCBI |
| PEX13 | Peroxisomal membrane protein PEX13 (Peroxin-13) | 5 | UniProt NCBI |
| SPX | Spexin (NPQ) (Neuropeptide Q) (Spexin hormone) [Cleaved into: Spexin-1; Spexin-2 (NPQ 53-70)] | 5 | UniProt NCBI |
| C6orf226 | Uncharacterized protein C6orf226 | 2 | UniProt NCBI |
| ACAA1 | 3-ketoacyl-CoA thiolase, peroxisomal (EC 2.3.1.16) (Acetyl-CoA C-myristoyltransferase) (EC 2.3.1.155) (Acetyl-CoA acyltransferase) (EC 2.3.1.9) (Beta-ketothiolase) (Peroxisomal 3-oxoacyl-CoA thiolase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04146 | 6.04798476505e-07 | 0.571428571429 | ACAA1 PEX13 PEX7 PHYH | Peroxisome |
| REAC:R-HSA-9033241 | 6.89554075554e-07 | 0.571428571429 | ACAA1 PEX13 PEX7 PHYH | Peroxisomal protein import |
| HP:0010965 | 2.07085763531e-05 | 0.428571428571 | PEX13 PEX7 PHYH | Abnormal circulating phytanic acid concentration |
| HP:0010571 | 2.07085763531e-05 | 0.428571428571 | PEX13 PEX7 PHYH | Elevated circulating phytanic acid concentration |
| HP:0010964 | 3.18462612707e-05 | 0.428571428571 | PEX13 PEX7 PHYH | Abnormal circulating long-chain fatty-acid concentration |
| REAC:R-HSA-9609507 | 4.76192041812e-05 | 0.571428571429 | ACAA1 PEX13 PEX7 PHYH | Protein localization |
| HP:4000163 | 0.000166647713928 | 0.285714285714 | PEX7 PHYH | Reduced phytanic acid oxidase activity in cultured fibroblasts |
| REAC:R-HSA-9033500 | 0.000571118993049 | 0.285714285714 | PHYH ACAA1 | TYSND1 cleaves peroxisomal proteins |
| HP:0004359 | 0.00110685540724 | 0.428571428571 | PEX13 PEX7 PHYH | Abnormal circulating fatty-acid concentration |
| GO:0005777 | 0.00449874442284 | 0.571428571429 | ACAA1 PEX13 PEX7 PHYH | peroxisome |
| GO:0042579 | 0.00449874442284 | 0.571428571429 | ACAA1 PEX13 PEX7 PHYH | microbody |
| HP:0002654 | 0.0046597529865 | 0.285714285714 | PEX7 PHYH | Multiple epiphyseal dysplasia |
| REAC:R-HSA-390918 | 0.00721110026367 | 0.285714285714 | PHYH ACAA1 | Peroxisomal lipid metabolism |
| HP:0040035 | 0.0129659395038 | 0.285714285714 | PEX7 PHYH | Abnormality of the fourth metatarsal bone |
| HP:0004689 | 0.0129659395038 | 0.285714285714 | PEX7 PHYH | Short fourth metatarsal |
| HP:4000195 | 0.0151234779917 | 0.285714285714 | PEX7 PHYH | Abnormal enzyme activity in cultured fibroblasts |
| HP:0008064 | 0.0164273557067 | 0.428571428571 | PEX13 PEX7 PHYH | Ichthyosis |
| GO:0031907 | 0.0329865610647 | 0.428571428571 | ACAA1 PEX7 PHYH | microbody lumen |
| GO:0005782 | 0.0329865610647 | 0.428571428571 | ACAA1 PEX7 PHYH | peroxisomal matrix |
| HP:0000616 | 0.0348446257606 | 0.285714285714 | PEX7 PHYH | Miosis |
| HP:0002652 | 0.0356200251306 | 0.428571428571 | PEX13 PEX7 PHYH | Skeletal dysplasia |
| HP:0000662 | 0.0499840105553 | 0.428571428571 | PEX13 PEX7 PHYH | Nyctalopia |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| C6orf226 | PEX7 | 1.0 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PHYH | C6orf226 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| C6orf226 | ACAA1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| PEX7 | PEX13 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ACAA1 | PEX7 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PHYH | PEX7 | 0.996 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NANOS1 | PHYH | 0.953 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| C6orf226 | PEX13 | 0.921 |
mutually_exclusive (O00628)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| ACAA1 | SPX | 0.912 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| PHYH | ACAA1 | 0.164 | 0.144 | bioplex_WMM bioplex3_WMM WMM_only | |
| ACAA1 | PEX13 | 0.027 | 0.11 | bioplex3_WMM WMM_only |
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