hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_15160.1
Complex Portal: CPX-14992
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| C1orf159 | Uncharacterized protein C1orf159 | 3 | UniProt NCBI |
| GBP5 | Guanylate-binding protein 5 (EC 3.6.5.-) (GBP-TA antigen) (GTP-binding protein 5) (GBP-5) (Guanine nucleotide-binding protein 5) | 5 | UniProt NCBI |
| GBP3 | Guanylate-binding protein 3 (EC 3.6.5.-) (GTP-binding protein 3) (GBP-3) (Guanine nucleotide-binding protein 3) | 5 | UniProt NCBI |
| GBP1 | Guanylate-binding protein 1 (EC 3.6.1.-) (EC 3.6.5.-) (GTP-binding protein 1) (GBP-1) (HuGBP-1) (hGBP1) (Guanine nucleotide-binding protein 1) (Interferon-induced guanylate-binding protein 1) | 5 | UniProt NCBI |
| CASP6 | Caspase-6 (CASP-6) (CSP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18 (Caspase-6 subunit p20); Caspase-6 subunit p11 (Caspase-6 subunit p10)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0070269 | 9.61435992643e-07 | 0.8 | CASP6 GBP1 GBP5 GBP3 | pyroptosis |
| GO:0140639 | 9.61003071434e-06 | 0.6 | GBP1 GBP5 GBP3 | positive regulation of pyroptosis |
| GO:0051715 | 1.92180881975e-05 | 0.6 | GBP1 GBP5 GBP3 | cytolysis in another organism |
| GO:0019835 | 3.362820138e-05 | 0.6 | GBP1 GBP5 GBP3 | cytolysis |
| REAC:R-HSA-877300 | 0.000217750033404 | 0.6 | GBP1 GBP5 GBP3 | Interferon gamma signaling |
| KEGG:04621 | 0.000467209213785 | 0.6 | GBP1 GBP5 GBP3 | NOD-like receptor signaling pathway |
| REAC:R-HSA-913531 | 0.00269181495124 | 0.6 | GBP1 GBP5 GBP3 | Interferon Signaling |
| GO:0031640 | 0.0109904490822 | 0.6 | GBP1 GBP5 GBP3 | killing of cells of another organism |
| GO:0141061 | 0.0109904490822 | 0.6 | GBP1 GBP5 GBP3 | disruption of cell in another organism |
| GO:0141060 | 0.0145266888919 | 0.6 | GBP1 GBP5 GBP3 | disruption of anatomical structure in another organism |
| GO:0071346 | 0.0379355065545 | 0.6 | GBP1 GBP5 GBP3 | cellular response to type II interferon |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GBP3 | GBP1 | 0.998 |
mutually_exclusive (P32456)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GBP5 | GBP1 | 0.987 | 0.21 |
mutually_exclusive (P32456)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GBP5 | C1orf159 | 0.926 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| GBP3 | CASP6 | 0.895 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| GBP5 | GBP3 | 0.868 | bioplex_WMM bioplex3_WMM WMM_only | ||
| GBP1 | C1orf159 | 0.143 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes