hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_15164.1
Complex Portal: CPX-14653
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DHX8 | ATP-dependent RNA helicase DHX8 (EC 3.6.4.13) (DEAH box protein 8) (RNA helicase HRH1) | 5 | UniProt NCBI |
| SLU7 | Pre-mRNA-splicing factor SLU7 (hSlu7) | 5 | UniProt NCBI |
| C1orf52 | UPF0690 protein C1orf52 (BCL10-associated gene protein) | 3 | UniProt NCBI |
| RAB43 | Ras-related protein Rab-43 (Ras-related protein Rab-41) | 5 | UniProt NCBI |
| LHFPL2 | LHFPL tetraspan subfamily member 2 protein (Lipoma HMGIC fusion partner-like 2 protein) | 5 | UniProt NCBI |
| NUDCD1 | NudC domain-containing protein 1 (Chronic myelogenous leukemia tumor antigen 66) (Tumor antigen CML66) | 5 | UniProt NCBI |
| HIVEP1 | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | 5 | UniProt NCBI |
| STEEP1 | STING ER exit protein (STEEP) | 5 | UniProt NCBI |
| ZNF830 | Zinc finger protein 830 (Coiled-coil domain-containing protein 16) | 5 | UniProt NCBI |
| CACTIN | Splicing factor Cactin (Renal carcinoma antigen NY-REN-24) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-72163 | 1.33674719728e-05 | 0.555555555556 | DHX8 ZNF830 SLU7 CACTIN STEEP1 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 1.58643659332e-05 | 0.555555555556 | DHX8 ZNF830 SLU7 CACTIN STEEP1 | mRNA Splicing |
| REAC:R-HSA-72203 | 6.27092099804e-05 | 0.555555555556 | DHX8 ZNF830 SLU7 CACTIN STEEP1 | Processing of Capped Intron-Containing Pre-mRNA |
| CORUM:1181 | 0.000937164056266 | 0.333333333333 | DHX8 SLU7 CACTIN | C complex spliceosome |
| CORUM:351 | 0.00527216248346 | 0.333333333333 | DHX8 SLU7 CACTIN | Spliceosome |
| REAC:R-HSA-8953854 | 0.00564646741329 | 0.555555555556 | DHX8 ZNF830 SLU7 CACTIN STEEP1 | Metabolism of RNA |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| STEEP1 | CACTIN | 0.996 | 0.436 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| CACTIN | DHX8 | 0.995 | 0.412 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| C1orf52 | ZNF830 | 0.989 | 0.116 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| SLU7 | DHX8 | 0.982 | 0.248 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM WMM_only |
| NUDCD1 | DHX8 | 0.97 | 0.084 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| C1orf52 | DHX8 | 0.97 | 0.04 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| ZNF830 | RAB43 | 0.969 | 0.024 | hein_WMM hein () | |
| C1orf52 | RAB43 | 0.969 | 0.036 | hein_WMM hein () | |
| CACTIN | RAB43 | 0.966 | 0.05 | hein_WMM hein () | |
| DHX8 | RAB43 | 0.965 | 0.082 | hein_WMM hein () | |
| SLU7 | RAB43 | 0.965 | 0.042 | hein_WMM hein () | |
| ZNF830 | DHX8 | 0.944 | 0.372 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| SLU7 | CACTIN | 0.904 | 0.158 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| C1orf52 | HIVEP1 | 0.888 | 0.096 | hein_WMM bioplex3_WMM WMM_only | |
| SLU7 | ZNF830 | 0.883 | 0.438 | hein_WMM youn_WMM gupta_WMM WMM_only | |
| ZNF830 | CACTIN | 0.859 | 0.284 | hein_WMM youn_WMM gupta_WMM WMM_only | |
| SLU7 | C1orf52 | 0.847 | 0.044 | hein_WMM gupta_WMM WMM_only | |
| RAB43 | LHFPL2 | 0.842 | 0.086 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| C1orf52 | CACTIN | 0.691 | 0.052 | hein_WMM gupta_WMM WMM_only | |
| C1orf52 | NUDCD1 | 0.276 | 0.044 | bioplex3_WMM WMM_only | |
| STEEP1 | DHX8 | 0.121 | 0.502 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| NUDCD1 | CACTIN | 0.065 | 0.082 | bioplex_WMM bioplex3_WMM WMM_only | |
| SLU7 | STEEP1 | 0.047 | 0.136 | bioplex3_HEK293 gupta_WMM WMM_only | |
| SLU7 | NUDCD1 | 0.028 | 0.034 |
mutually_exclusive (Q14562)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
| ZNF830 | HIVEP1 | 0.023 | 0.086 | youn_WMM WMM_only | |
| DHX8 | HIVEP1 | 0.017 | 0.144 | youn_WMM WMM_only | |
| NUDCD1 | HIVEP1 | 0.013 | 0.132 | bioplex3_WMM WMM_only | |
| CACTIN | HIVEP1 | 0.013 | 0.08 | bioplex3_WMM youn_WMM WMM_only | |
| SLU7 | HIVEP1 | 0.013 | 0.042 | youn_WMM WMM_only | |
| ZNF830 | STEEP1 | 0.012 | 0.276 | gupta_WMM WMM_only | |
| C1orf52 | STEEP1 | 0.01 | 0.154 | gupta_WMM WMM_only | |
| NUDCD1 | ZNF830 | 0.003 | 0.066 | fraction | |
| STEEP1 | RAB43 | 0.002 | 0.058 | bioplex3_HCT116 WMM_only | |
| NUDCD1 | STEEP1 | 0.001 | 0.102 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes