hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_15175.1
Complex Portal: CPX-14123
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FNIP1 | Folliculin-interacting protein 1 | 5 | UniProt NCBI |
| FNIP2 | Folliculin-interacting protein 2 (FNIP1-like protein) (O6-methylguanine-induced apoptosis 1 protein) | 5 | UniProt NCBI |
| FLCN | Folliculin (BHD skin lesion fibrofolliculoma protein) (Birt-Hogg-Dube syndrome protein) | 5 | UniProt NCBI |
| CPXCR1 | CPX chromosomal region candidate gene 1 protein (Cancer/testis antigen 77) (CT77) | 2 | UniProt NCBI |
| ZFYVE19 | Abscission/NoCut checkpoint regulator (ANCHR) (MLL partner containing FYVE domain) (Zinc finger FYVE domain-containing protein 19) | 5 | UniProt NCBI |
| CHMP1B | Charged multivesicular body protein 1b (CHMP1.5) (Chromatin-modifying protein 1b) (CHMP1b) (Vacuolar protein sorting-associated protein 46-2) (Vps46-2) (hVps46-2) | 5 | UniProt NCBI |
| VTA1 | Vacuolar protein sorting-associated protein VTA1 homolog (Dopamine-responsive gene 1 protein) (DRG-1) (LYST-interacting protein 5) (LIP5) (SKD1-binding protein 1) (SBP1) | 5 | UniProt NCBI |
| LAMTOR5 | Ragulator complex protein LAMTOR5 (Hepatitis B virus X-interacting protein) (HBV X-interacting protein) (HBX-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9639288 | 2.27057596428e-06 | 0.5 | FNIP1 LAMTOR5 FLCN FNIP2 | Amino acids regulate mTORC1 |
| CORUM:7430 | 2.39226645298e-05 | 0.25 | FNIP2 FLCN | FLCN-FNIP2 complex |
| KEGG:04150 | 3.39066033667e-05 | 0.5 | FNIP1 LAMTOR5 FLCN FNIP2 | mTOR signaling pathway |
| REAC:R-HSA-9711097 | 0.00016648002646 | 0.5 | FNIP1 LAMTOR5 FLCN FNIP2 | Cellular response to starvation |
| GO:1904263 | 0.000419928845551 | 0.5 | FNIP1 LAMTOR5 FLCN FNIP2 | positive regulation of TORC1 signaling |
| GO:1990877 | 0.000644767051209 | 0.375 | FNIP2 LAMTOR5 FLCN | FNIP-folliculin RagC/D GAP |
| GO:1902773 | 0.000886327111509 | 0.375 | FNIP2 LAMTOR5 FLCN | GTPase activator complex |
| GO:0032008 | 0.00123045452734 | 0.5 | FNIP1 LAMTOR5 FLCN FNIP2 | positive regulation of TOR signaling |
| GO:0150005 | 0.00300428100757 | 0.375 | FNIP2 LAMTOR5 FLCN | enzyme activator complex |
| GO:1903432 | 0.00366371076373 | 0.5 | FNIP1 LAMTOR5 FLCN FNIP2 | regulation of TORC1 signaling |
| WP:WP5381 | 0.00424405942449 | 0.375 | FNIP1 FLCN FNIP2 | Smith Magenis and Potocki Lupski syndrome copy number variation |
| GO:0038202 | 0.00441407178313 | 0.5 | FNIP1 LAMTOR5 FLCN FNIP2 | TORC1 signaling |
| GO:0032006 | 0.0168296561278 | 0.5 | FNIP1 LAMTOR5 FLCN FNIP2 | regulation of TOR signaling |
| GO:0031929 | 0.0258663823582 | 0.5 | FNIP1 LAMTOR5 FLCN FNIP2 | TOR signaling |
| GO:1905672 | 0.0393180950424 | 0.25 | FNIP1 FLCN | negative regulation of lysosome organization |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| FNIP1 | FNIP2 | 0.997 |
mutually_exclusive (Q8NFG4)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| VTA1 | CHMP1B | 0.994 | 0.052 | hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FNIP1 | VTA1 | 0.992 | 0.088 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FNIP2 | VTA1 | 0.991 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| VTA1 | FLCN | 0.987 | 0.196 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CPXCR1 | VTA1 | 0.978 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| VTA1 | ZFYVE19 | 0.947 | 0.108 | bioplex3_HEK293 bioplex3_WMM bioplex_WMM WMM_only | |
| FNIP2 | LAMTOR5 | 0.907 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ZFYVE19 | CHMP1B | 0.881 | 0.038 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| LAMTOR5 | FLCN | 0.859 | 0.166 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| FNIP2 | FLCN | 0.789 |
structurally_consistent (dimer)
|
bioplex3_WMM WMM_only | |
| FNIP1 | FLCN | 0.72 | 0.16 |
structurally_consistent (dimer)
|
bioplex3_WMM WMM_only |
| FNIP1 | ZFYVE19 | 0.274 | 0.092 | bioplex3_WMM WMM_only | |
| FNIP2 | ZFYVE19 | 0.146 | bioplex3_WMM WMM_only | ||
| ZFYVE19 | FLCN | 0.076 | 0.162 | bioplex3_WMM WMM_only | |
| VTA1 | LAMTOR5 | 0.024 | 0.036 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ZFYVE19 | LAMTOR5 | 0.017 | 0.096 | bioplex3_WMM WMM_only | |
| CPXCR1 | LAMTOR5 | 0.016 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| FNIP1 | LAMTOR5 | 0.014 | 0.116 | bioplex3_WMM WMM_only |
Related Complexes