hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_15176.1

Complex Portal: CPX-20414

Confidence: Medium

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Genename	Protein Name	Uniprot Annotation Score	Links
CDC25C	M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C)	5	UniProt NCBI
NPHP1	Nephrocystin-1 (Juvenile nephronophthisis 1 protein)	5	UniProt NCBI
NPHP4	Nephrocystin-4 (Nephroretinin)	5	UniProt NCBI
RPGR	X-linked retinitis pigmentosa GTPase regulator	5	UniProt NCBI
RPGRIP1L	Protein fantom (Nephrocystin-8) (RPGR-interacting protein 1-like protein) (RPGRIP1-like protein)	5	UniProt NCBI
TRAIP	E3 ubiquitin-protein ligase TRAIP (EC 2.3.2.27) (RING finger protein 206) (TRAF-interacting protein)	5	UniProt NCBI

Showing 1 to 6 of 6 entries

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Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP5399	1.44800475023e-07	0.6	NPHP4 RPGRIP1L NPHP1	NPHP1 deletion syndrome
HP:0000092	1.07278390181e-05	0.6	NPHP4 RPGRIP1L NPHP1	Renal tubular atrophy
HP:0032599	1.07278390181e-05	0.6	NPHP4 RPGRIP1L NPHP1	Abnormal renal tubular epithelial morphology
CORUM:6381	4.09448956317e-05	0.4	NPHP4 NPHP1	NPHP1-NPHP4-BCAR1 complex
WP:WP4656	6.85359532624e-05	0.6	NPHP4 RPGRIP1L NPHP1	Joubert syndrome
HP:0000090	7.85415640073e-05	0.6	NPHP4 RPGRIP1L NPHP1	Nephronophthisis
CORUM:6681	8.18785830799e-05	0.4	NPHP4 RPGRIP1L	DVL2-INVS-NPHP4-RPGRIP1L complex
HP:0002612	0.000119890110367	0.6	NPHP4 RPGRIP1L NPHP1	Congenital hepatic fibrosis
GO:0097730	0.000252739304428	0.8	NPHP4 NPHP1 RPGRIP1L RPGR	non-motile cilium
HP:0032581	0.000324889930266	0.6	NPHP4 RPGRIP1L NPHP1	Abnormal renal insterstitial morphology

Showing 1 to 10 of 51 entries

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Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
RPGRIP1L	RPGR	0.999	0.118		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta () boldt bioplex3_HCT116 boldt_WMM
RPGR	NPHP1	0.999			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM
NPHP4	RPGR	0.998	0.062		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta () boldt bioplex3_HCT116 gupta_WMM boldt_WMM
NPHP4	NPHP1	0.996		structurally_consistent (dimer)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta () boldt gupta_WMM boldt_WMM
RPGRIP1L	NPHP1	0.993		structurally_consistent (O75161)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta () boldt gupta_WMM boldt_WMM
TRAIP	NPHP1	0.983			bioplex3_HEK293 bioplex3_WMM WMM_only
CDC25C	RPGR	0.941	0.118		bioplex3_HEK293 bioplex3_WMM WMM_only
RPGRIP1L	NPHP4	0.859	0.092	structurally_consistent (dimer)	bioplex_WMM bioplex3_WMM gupta () boldt youn_WMM gupta_WMM boldt_WMM
RPGRIP1L	TRAIP	0.25			bioplex3_WMM WMM_only
TRAIP	NPHP4	0.078			bioplex3_WMM WMM_only

Showing 1 to 10 of 10 entries

Related Complexes

Genename	Complexes
RPGRIP1L	huMAP3_04884.1 huMAP3_12616.1 huMAP3_14472.1 huMAP3_15176.1
TRAIP	huMAP3_04884.1 huMAP3_12616.1 huMAP3_14073.1 huMAP3_14472.1 huMAP3_15176.1
NPHP4	huMAP3_04884.1 huMAP3_15176.1
RPGR	huMAP3_04884.1 huMAP3_13233.1 huMAP3_13344.1 huMAP3_13572.1 huMAP3_14472.1 huMAP3_15176.1
CDC25C	huMAP3_01816.1 huMAP3_02188.1 huMAP3_13233.1 huMAP3_13344.1 huMAP3_14472.1 huMAP3_14985.1 huMAP3_15176.1
NPHP1	huMAP3_04884.1 huMAP3_12616.1 huMAP3_14073.1 huMAP3_14472.1 huMAP3_15176.1