hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_15176.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RPGRIP1L | Protein fantom (Nephrocystin-8) (RPGR-interacting protein 1-like protein) (RPGRIP1-like protein) | 5 | UniProt NCBI |
| TRAIP | E3 ubiquitin-protein ligase TRAIP (EC 2.3.2.27) (RING finger protein 206) (TRAF-interacting protein) | 5 | UniProt NCBI |
| NPHP4 | Nephrocystin-4 (Nephroretinin) | 5 | UniProt NCBI |
| RPGR | X-linked retinitis pigmentosa GTPase regulator | 5 | UniProt NCBI |
| CDC25C | M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C) | 5 | UniProt NCBI |
| NPHP1 | Nephrocystin-1 (Juvenile nephronophthisis 1 protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5399 | 1.44800475023e-07 | 0.6 | NPHP1 RPGRIP1L NPHP4 | NPHP1 deletion syndrome |
| HP:0000092 | 1.07278390181e-05 | 0.6 | NPHP1 RPGRIP1L NPHP4 | Renal tubular atrophy |
| HP:0032599 | 1.07278390181e-05 | 0.6 | NPHP1 RPGRIP1L NPHP4 | Abnormal renal tubular epithelial morphology |
| CORUM:6381 | 4.09448956317e-05 | 0.4 | NPHP1 NPHP4 | NPHP1-NPHP4-BCAR1 complex |
| WP:WP4656 | 6.85359532624e-05 | 0.6 | NPHP1 RPGRIP1L NPHP4 | Joubert syndrome |
| HP:0000090 | 7.85415640073e-05 | 0.6 | NPHP1 RPGRIP1L NPHP4 | Nephronophthisis |
| CORUM:6681 | 8.18785830799e-05 | 0.4 | RPGRIP1L NPHP4 | DVL2-INVS-NPHP4-RPGRIP1L complex |
| HP:0002612 | 0.000119890110367 | 0.6 | NPHP1 RPGRIP1L NPHP4 | Congenital hepatic fibrosis |
| GO:0097730 | 0.000252739304428 | 0.8 | NPHP1 RPGR RPGRIP1L NPHP4 | non-motile cilium |
| HP:0032581 | 0.000324889930266 | 0.6 | NPHP1 RPGRIP1L NPHP4 | Abnormal renal insterstitial morphology |
| HP:0100957 | 0.000324889930266 | 0.6 | NPHP1 RPGRIP1L NPHP4 | Abnormal renal medulla morphology |
| REAC:R-HSA-5620912 | 0.000401238804144 | 0.6 | NPHP1 RPGRIP1L NPHP4 | Anchoring of the basal body to the plasma membrane |
| HPA:0060873 | 0.000523626766967 | 0.6 | RPGR NPHP4 NPHP1 | bronchus; ciliated cells (ciliary rootlets)[High] |
| HP:0000556 | 0.000548333242706 | 0.8 | NPHP1 RPGR RPGRIP1L NPHP4 | Retinal dystrophy |
| HP:0010579 | 0.000715820213284 | 0.6 | NPHP1 TRAIP NPHP4 | Cone-shaped epiphysis |
| WP:WP4803 | 0.000737700711921 | 0.6 | NPHP1 RPGRIP1L NPHP4 | Ciliopathies |
| HP:0000091 | 0.00119989499053 | 0.6 | NPHP1 RPGRIP1L NPHP4 | Abnormal renal tubule morphology |
| HP:0000108 | 0.001345957274 | 0.4 | NPHP1 NPHP4 | Renal corticomedullary cysts |
| HP:0003774 | 0.0032987458644 | 0.6 | NPHP1 RPGRIP1L NPHP4 | Stage 5 chronic kidney disease |
| REAC:R-HSA-5617833 | 0.0033903418593 | 0.6 | NPHP1 RPGRIP1L NPHP4 | Cilium Assembly |
| HP:0005576 | 0.0035231963033 | 0.4 | NPHP1 NPHP4 | Tubulointerstitial fibrosis |
| HP:0001395 | 0.00423196482148 | 0.6 | NPHP1 RPGRIP1L NPHP4 | Hepatic fibrosis |
| HP:0030760 | 0.00499516489297 | 0.4 | NPHP1 NPHP4 | Renal fibrosis |
| HP:0000078 | 0.00583084299782 | 1.0 | NPHP1 RPGR RPGRIP1L NPHP4 TRAIP | Abnormality of the genital system |
| HP:0012622 | 0.0096934870879 | 0.6 | NPHP1 RPGRIP1L NPHP4 | Chronic kidney disease |
| HPA:0060872 | 0.00983604287223 | 0.6 | RPGR NPHP4 NPHP1 | bronchus; ciliated cells (ciliary rootlets)[>=Medium] |
| HP:0011844 | 0.0100255412082 | 1.0 | NPHP1 RPGR RPGRIP1L NPHP4 TRAIP | Abnormal appendicular skeleton morphology |
| REAC:R-HSA-1852241 | 0.0104028281978 | 0.6 | NPHP1 RPGRIP1L NPHP4 | Organelle biogenesis and maintenance |
| HP:0011314 | 0.0123480518851 | 0.8 | NPHP1 RPGRIP1L NPHP4 TRAIP | Abnormal long bone morphology |
| HP:0000103 | 0.0147751514018 | 0.4 | NPHP1 NPHP4 | Polyuria |
| GO:0035869 | 0.016548216138 | 0.6 | NPHP1 RPGRIP1L NPHP4 | ciliary transition zone |
| HP:0000518 | 0.0170972280008 | 0.8 | NPHP1 RPGR RPGRIP1L NPHP4 | Cataract |
| HP:0000517 | 0.0189122123602 | 0.8 | NPHP1 RPGR RPGRIP1L NPHP4 | Abnormal lens morphology |
| HPA:0060871 | 0.0208631636822 | 0.6 | RPGR NPHP4 NPHP1 | bronchus; ciliated cells (ciliary rootlets)[>=Low] |
| HP:0012575 | 0.021931816569 | 0.6 | NPHP1 RPGRIP1L NPHP4 | Abnormal nephron morphology |
| HP:0000276 | 0.0257431724127 | 0.6 | NPHP1 RPGRIP1L TRAIP | Long face |
| HP:0005930 | 0.0264180981427 | 0.6 | NPHP1 TRAIP NPHP4 | Abnormal epiphysis morphology |
| HP:0001959 | 0.0297055420477 | 0.4 | NPHP1 NPHP4 | Polydipsia |
| HP:0030082 | 0.0297055420477 | 0.4 | NPHP1 NPHP4 | Abnormal drinking behavior |
| HP:0000107 | 0.031092077037 | 0.6 | NPHP1 RPGRIP1L NPHP4 | Renal cyst |
| HP:0000479 | 0.0311226311043 | 0.8 | NPHP1 RPGR RPGRIP1L NPHP4 | Abnormal retinal morphology |
| GO:0097733 | 0.0327001087246 | 0.6 | RPGR RPGRIP1L NPHP1 | photoreceptor cell cilium |
| HP:0100729 | 0.0342232629352 | 0.6 | NPHP1 RPGRIP1L TRAIP | Large face |
| HP:0002419 | 0.0358235710582 | 0.4 | NPHP1 RPGRIP1L | Molar tooth sign on MRI |
| HP:0002118 | 0.0359245823678 | 0.8 | NPHP1 RPGR RPGRIP1L TRAIP | Abnormal cerebral ventricle morphology |
| HP:0012758 | 0.0415820723964 | 1.0 | NPHP1 RPGR RPGRIP1L NPHP4 TRAIP | Neurodevelopmental delay |
| GO:0097731 | 0.0417184596383 | 0.6 | RPGR RPGRIP1L NPHP1 | 9+0 non-motile cilium |
| HP:0012373 | 0.0423817045686 | 1.0 | NPHP1 RPGR RPGRIP1L NPHP4 TRAIP | Abnormal eye physiology |
| HP:0007703 | 0.0429461819912 | 0.6 | RPGR NPHP4 NPHP1 | Abnormality of retinal pigmentation |
| GO:1903348 | 0.0468008499735 | 0.4 | NPHP1 NPHP4 | positive regulation of bicellular tight junction assembly |
| HP:0000639 | 0.0475707538639 | 0.8 | NPHP1 RPGR RPGRIP1L NPHP4 | Nystagmus |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RPGRIP1L | RPGR | 0.999 | 0.118 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta () boldt bioplex3_HCT116 boldt_WMM |
| RPGR | NPHP1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM | |
| NPHP4 | RPGR | 0.998 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta () boldt bioplex3_HCT116 gupta_WMM boldt_WMM |
| NPHP4 | NPHP1 | 0.996 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta () boldt gupta_WMM boldt_WMM | |
| RPGRIP1L | NPHP1 | 0.993 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta () boldt gupta_WMM boldt_WMM | |
| TRAIP | NPHP1 | 0.983 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CDC25C | RPGR | 0.941 | 0.118 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| RPGRIP1L | NPHP4 | 0.859 | 0.092 | bioplex_WMM bioplex3_WMM gupta () boldt youn_WMM gupta_WMM boldt_WMM |
| RPGRIP1L | TRAIP | 0.25 | bioplex3_WMM WMM_only | |
| TRAIP | NPHP4 | 0.078 | bioplex3_WMM WMM_only |
Related Complexes