hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_15191.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MBD5 | Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5) | 5 | UniProt NCBI |
| BAP1 | Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) | 5 | UniProt NCBI |
| ASXL1 | Polycomb group protein ASXL1 (Additional sex combs-like protein 1) | 5 | UniProt NCBI |
| ASXL3 | Putative Polycomb group protein ASXL3 (Additional sex combs-like protein 3) | 5 | UniProt NCBI |
| ASXL2 | Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) | 5 | UniProt NCBI |
| NSD3 | Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1) | 5 | UniProt NCBI |
| KDM1B | Lysine-specific histone demethylase 2 (EC 1.14.99.66) (Flavin-containing amine oxidase domain-containing protein 1) (Lysine-specific histone demethylase 1B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0035517 | 9.2094208532e-10 | 0.571428571429 | ASXL3 ASXL2 BAP1 ASXL1 | PR-DUB complex |
| KEGG:03083 | 5.01349943828e-09 | 0.714285714286 | ASXL3 MBD5 ASXL2 BAP1 ASXL1 | Polycomb repressive complex |
| REAC:R-HSA-5689603 | 3.37502895711e-08 | 0.714285714286 | MBD5 ASXL2 BAP1 KDM1B ASXL1 | UCH proteinases |
| REAC:R-HSA-5688426 | 5.45947084881e-06 | 0.714285714286 | MBD5 ASXL2 BAP1 KDM1B ASXL1 | Deubiquitination |
| HP:0000998 | 2.11260443232e-05 | 0.714285714286 | ASXL3 MBD5 ASXL2 BAP1 ASXL1 | Hypertrichosis |
| WP:WP5351 | 2.21509180757e-05 | 0.428571428571 | MBD5 BAP1 ASXL1 | Kleefstra syndrome |
| GO:0003682 | 8.38867285183e-05 | 0.857142857143 | KDM1B MBD5 ASXL3 ASXL1 ASXL2 BAP1 | chromatin binding |
| GO:0031519 | 0.000102438985779 | 0.571428571429 | ASXL3 ASXL2 BAP1 ASXL1 | PcG protein complex |
| HP:0006191 | 0.000114912442479 | 0.428571428571 | ASXL2 ASXL1 ASXL3 | Deep palmar crease |
| GO:0042975 | 0.000117650375223 | 0.428571428571 | ASXL2 ASXL1 ASXL3 | peroxisome proliferator activated receptor binding |
| HP:0000664 | 0.00044165257546 | 0.571428571429 | MBD5 ASXL2 ASXL1 ASXL3 | Synophrys |
| HP:0002219 | 0.000572900170312 | 0.571428571429 | MBD5 ASXL2 ASXL1 ASXL3 | Facial hypertrichosis |
| HP:0000520 | 0.0016494906913 | 0.571428571429 | ASXL3 ASXL2 BAP1 ASXL1 | Proptosis |
| HP:0011362 | 0.00536712082033 | 0.714285714286 | ASXL3 MBD5 ASXL2 BAP1 ASXL1 | Abnormal hair quantity |
| HP:0000278 | 0.00611855381738 | 0.571428571429 | MBD5 ASXL2 ASXL1 ASXL3 | Retrognathia |
| HP:0000369 | 0.00652702501281 | 0.714285714286 | ASXL3 MBD5 ASXL2 BAP1 ASXL1 | Low-set ears |
| HP:0010938 | 0.00713211764089 | 0.714285714286 | ASXL3 MBD5 ASXL2 BAP1 ASXL1 | Abnormal external nose morphology |
| HP:0000357 | 0.00857848314082 | 0.714285714286 | ASXL3 MBD5 ASXL2 BAP1 ASXL1 | Abnormal location of ears |
| HP:0000177 | 0.00972222521101 | 0.714285714286 | ASXL3 MBD5 ASXL2 BAP1 ASXL1 | Abnormal upper lip morphology |
| HP:0000527 | 0.0117122371727 | 0.428571428571 | MBD5 ASXL3 ASXL2 | Long eyelashes |
| HP:0005922 | 0.0140456236791 | 0.714285714286 | ASXL3 MBD5 ASXL2 BAP1 ASXL1 | Abnormal hand morphology |
| REAC:R-HSA-597592 | 0.0148745508598 | 0.714285714286 | MBD5 ASXL2 BAP1 KDM1B ASXL1 | Post-translational protein modification |
| HP:0011339 | 0.014908406472 | 0.571428571429 | MBD5 ASXL2 BAP1 ASXL3 | Abnormality of upper lip vermillion |
| HP:0000750 | 0.0172010853998 | 0.714285714286 | ASXL3 MBD5 ASXL2 BAP1 ASXL1 | Delayed speech and language development |
| HP:0100886 | 0.0181179803429 | 0.714285714286 | ASXL3 MBD5 ASXL2 BAP1 ASXL1 | Abnormality of globe location |
| HP:0002360 | 0.0186188605393 | 0.571428571429 | ASXL3 MBD5 BAP1 ASXL1 | Sleep abnormality |
| HP:0100871 | 0.0189709720562 | 0.571428571429 | MBD5 ASXL2 ASXL1 ASXL3 | Abnormal palm morphology |
| HP:0002463 | 0.0221791852322 | 0.714285714286 | ASXL3 MBD5 ASXL2 BAP1 ASXL1 | Language impairment |
| HP:0011968 | 0.0244625952771 | 0.714285714286 | ASXL3 MBD5 ASXL2 BAP1 ASXL1 | Feeding difficulties |
| HP:0003764 | 0.0253454447683 | 0.428571428571 | ASXL2 BAP1 ASXL1 | Nevus |
| HP:0000290 | 0.0271846378781 | 0.714285714286 | ASXL3 MBD5 ASXL2 BAP1 ASXL1 | Abnormality of the forehead |
| HP:0000159 | 0.0324448740401 | 0.714285714286 | ASXL3 MBD5 ASXL2 BAP1 ASXL1 | Abnormal lip morphology |
| HP:0000377 | 0.0400275127441 | 0.714285714286 | ASXL3 MBD5 ASXL2 BAP1 ASXL1 | Abnormal pinna morphology |
| HP:0000356 | 0.0421707957735 | 0.714285714286 | ASXL3 MBD5 ASXL2 BAP1 ASXL1 | Abnormality of the outer ear |
| HP:0001595 | 0.0434621805893 | 0.714285714286 | ASXL3 MBD5 ASXL2 BAP1 ASXL1 | Abnormal hair morphology |
| HP:0002000 | 0.0457644476584 | 0.285714285714 | MBD5 ASXL3 | Short columella |
| HP:0100023 | 0.0497326121949 | 0.285714285714 | MBD5 ASXL3 | Recurrent hand flapping |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ASXL2 | KDM1B | 0.999 | 0.226 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| ASXL2 | BAP1 | 0.998 | 0.292 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| KDM1B | BAP1 | 0.997 | 0.328 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| BAP1 | ASXL1 | 0.995 | 0.15 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116 |
| MBD5 | ASXL2 | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NSD3 | KDM1B | 0.963 | 0.292 | hein_WMM hein () |
| BAP1 | ASXL3 | 0.945 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| KDM1B | ASXL1 | 0.944 | 0.18 | hein_WMM bioplex3_WMM WMM_only |
| ASXL2 | ASXL1 | 0.933 | 0.204 | bioplex3_WMM WMM_only |
| MBD5 | BAP1 | 0.889 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| MBD5 | ASXL3 | 0.415 | bioplex3_WMM WMM_only | |
| ASXL2 | ASXL3 | 0.415 | bioplex3_WMM WMM_only | |
| MBD5 | ASXL1 | 0.415 | bioplex3_WMM WMM_only | |
| ASXL1 | ASXL3 | 0.415 | bioplex3_WMM WMM_only | |
| MBD5 | KDM1B | 0.275 | bioplex_WMM bioplex3_WMM WMM_only | |
| KDM1B | ASXL3 | 0.25 | bioplex3_WMM WMM_only | |
| ASXL2 | NSD3 | 0.138 | 0.098 | hein_WMM youn_WMM WMM_only |
| NSD3 | BAP1 | 0.087 | 0.402 | hein_WMM youn_WMM WMM_only |
Related Complexes