hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_15196.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TSPYL4 | Testis-specific Y-encoded-like protein 4 (TSPY-like protein 4) | 4 | UniProt NCBI |
| DFFB | DNA fragmentation factor subunit beta (EC 3.-.-.-) (Caspase-activated deoxyribonuclease) (CAD) (Caspase-activated DNase) (Caspase-activated nuclease) (CPAN) (DNA fragmentation factor 40 kDa subunit) (DFF-40) | 5 | UniProt NCBI |
| DFFA | DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD) | 5 | UniProt NCBI |
| NAP1L2 | Nucleosome assembly protein 1-like 2 (Brain-specific protein, X-linked) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-140342 | 0.000798898068561 | 0.5 | DFFB DFFA | Apoptosis induced DNA fragmentation |
| WP:WP314 | 0.00178944501344 | 0.5 | DFFB DFFA | Fas ligand pathway and stress induction of heat shock proteins |
| GO:1902511 | 0.0028092043205 | 0.5 | DFFB DFFA | negative regulation of apoptotic DNA fragmentation |
| GO:1903625 | 0.0028092043205 | 0.5 | DFFB DFFA | negative regulation of DNA catabolic process |
| WP:WP4298 | 0.0063063631888 | 0.5 | DFFB DFFA | Acute viral myocarditis |
| WP:WP254 | 0.00666804419641 | 0.5 | DFFB DFFA | Apoptosis |
| WP:WP1772 | 0.00761604886135 | 0.5 | DFFB DFFA | Apoptosis modulation and signaling |
| REAC:R-HSA-75153 | 0.0120053783973 | 0.5 | DFFB DFFA | Apoptotic execution phase |
| KEGG:04210 | 0.0177164397058 | 0.5 | DFFB DFFA | Apoptosis |
| GO:1902510 | 0.0280843539964 | 0.5 | DFFB DFFA | regulation of apoptotic DNA fragmentation |
| GO:1903624 | 0.0280843539964 | 0.5 | DFFB DFFA | regulation of DNA catabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DFFA | DFFB | 1.0 | 0.172 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TSPYL4 | DFFA | 1.0 | 0.106 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TSPYL4 | NAP1L2 | 0.927 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| TSPYL4 | DFFB | 0.921 | 0.144 | bioplex_WMM bioplex3_WMM WMM_only |
| DFFA | NAP1L2 | 0.017 | bioplex3_HEK293 WMM_only |
Related Complexes