hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_15199.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SLCO1B3 | Solute carrier organic anion transporter family member 1B3 (Liver-specific organic anion transporter 2) (LST-2) (OATP1B3) (Organic anion transporter 8) (Organic anion-transporting polypeptide 8) (OATP-8) (Solute carrier family 21 member 8) | 5 | UniProt NCBI |
| SLC5A5 | Sodium/iodide cotransporter (Na(+)/I(-) cotransporter) (Natrium iodide transporter) (Sodium-iodide symporter) (Na(+)/I(-) symporter) (Solute carrier family 5 member 5) | 5 | UniProt NCBI |
| SLCO1B1 | Solute carrier organic anion transporter family member 1B1 (SLCO1B1) (Liver-specific organic anion transporter 1) (LST-1) (OATP-C) (Organic anion transporter SLC21A6) (Sodium-independent organic anion-transporting polypeptide 2) (OATP-2) (Solute carrier family 21 member 6) | 5 | UniProt NCBI |
| ORMDL2 | ORM1-like protein 2 (Adoplin-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0031811 | 3.34429085774e-05 | 0.5 | SLCO1B3 SLCO1B1 | Bilirubinuria |
| REAC:R-HSA-5619102 | 7.65476877178e-05 | 0.75 | SLCO1B1 SLCO1B3 SLC5A5 | SLC transporter disorders |
| WP:WP5396 | 0.000114838123418 | 0.5 | SLCO1B3 SLCO1B1 | Enterohepatic circulation of bile acids |
| WP:WP5368 | 0.000114838123418 | 0.5 | SLCO1B3 SLCO1B1 | Sulfatase and aromatase pathway |
| REAC:R-HSA-879518 | 0.000153732433522 | 0.5 | SLCO1B3 SLCO1B1 | Transport of organic anions |
| REAC:R-HSA-9754706 | 0.000286914834749 | 0.5 | SLCO1B3 SLCO1B1 | Atorvastatin ADME |
| HP:0001046 | 0.000334337547576 | 0.5 | SLCO1B3 SLCO1B1 | Intermittent jaundice |
| WP:WP5176 | 0.000346844620397 | 0.5 | SLCO1B3 SLCO1B1 | Disorders of bile acid synthesis and biliary transport |
| HP:0032106 | 0.000501460556964 | 0.5 | SLCO1B3 SLCO1B1 | Conjunctival icterus |
| REAC:R-HSA-5619115 | 0.000637157683969 | 0.75 | SLCO1B1 SLCO1B3 SLC5A5 | Disorders of transmembrane transporters |
| HP:0002904 | 0.000671598193523 | 0.75 | SLCO1B1 SLCO1B3 SLC5A5 | Hyperbilirubinemia |
| REAC:R-HSA-189483 | 0.000676052383047 | 0.5 | SLCO1B3 SLCO1B1 | Heme degradation |
| REAC:R-HSA-159418 | 0.000676052383047 | 0.5 | SLCO1B3 SLCO1B1 | Recycling of bile acids and salts |
| HP:0033479 | 0.000692770824976 | 0.75 | SLCO1B1 SLCO1B3 SLC5A5 | Abnormal circulating bilirubin concentration |
| REAC:R-HSA-425407 | 0.000932464709105 | 0.75 | SLCO1B1 SLCO1B3 SLC5A5 | SLC-mediated transmembrane transport |
| HP:0010473 | 0.000935888865729 | 0.5 | SLCO1B3 SLCO1B1 | Porphyrinuria |
| HP:0010995 | 0.00134310215964 | 0.75 | SLCO1B1 SLCO1B3 SLC5A5 | Abnormal circulating dicarboxylic acid concentration |
| REAC:R-HSA-189445 | 0.00236402400204 | 0.5 | SLCO1B3 SLCO1B1 | Metabolism of porphyrins |
| HP:0010984 | 0.00260592941411 | 0.5 | SLCO1B3 SLCO1B1 | Digenic inheritance |
| HP:0000952 | 0.00405200286793 | 0.75 | SLCO1B1 SLCO1B3 SLC5A5 | Jaundice |
| KEGG:04976 | 0.00412492963649 | 0.5 | SLCO1B3 SLCO1B1 | Bile secretion |
| REAC:R-HSA-194068 | 0.00415229579539 | 0.5 | SLCO1B3 SLCO1B1 | Bile acid and bile salt metabolism |
| REAC:R-HSA-425397 | 0.00507136546841 | 0.5 | SLCO1B3 SLCO1B1 | Transport of vitamins, nucleosides, and related molecules |
| HP:0001396 | 0.00905423426659 | 0.75 | SLCO1B1 SLCO1B3 SLC5A5 | Cholestasis |
| HP:0002908 | 0.0100118295947 | 0.5 | SLCO1B3 SLCO1B1 | Conjugated hyperbilirubinemia |
| HP:0001005 | 0.0138474242728 | 0.75 | SLCO1B1 SLCO1B3 SLC5A5 | Dermatological manifestations of systemic disorders |
| HP:0004354 | 0.0153053110125 | 0.75 | SLCO1B1 SLCO1B3 SLC5A5 | Abnormal circulating carboxylic acid concentration |
| HP:0004297 | 0.0255174052948 | 0.75 | SLCO1B1 SLCO1B3 SLC5A5 | Abnormality of the biliary system |
| REAC:R-HSA-9748784 | 0.0329793636325 | 0.5 | SLCO1B3 SLCO1B1 | Drug ADME |
| REAC:R-HSA-382551 | 0.0342552713859 | 0.75 | SLCO1B1 SLCO1B3 SLC5A5 | Transport of small molecules |
| REAC:R-HSA-1430728 | 0.0393174957935 | 1.0 | SLCO1B1 ORMDL2 SLCO1B3 SLC5A5 | Metabolism |
| HPA:0120233 | 0.0424284218432 | 0.25 | SLC5A5 | choroid plexus; ependymal cells[High] |
| REAC:R-HSA-5619058 | 0.0499436884912 | 0.25 | SLCO1B3 | Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) |
| REAC:R-HSA-5619110 | 0.0499436884912 | 0.25 | SLCO1B1 | Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) |
| REAC:R-HSA-5619096 | 0.0499436884912 | 0.25 | SLC5A5 | Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SLCO1B3 | SLCO1B1 | 0.992 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SLC5A5 | ORMDL2 | 0.95 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SLCO1B1 | ORMDL2 | 0.945 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes