hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_15239.1
Complex Portal: CPX-25337
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TINAGL1 | Tubulointerstitial nephritis antigen-like (Glucocorticoid-inducible protein 5) (Oxidized LDL-responsive gene 2 protein) (OLRG-2) (Tubulointerstitial nephritis antigen-related protein) (TIN Ag-related protein) (TIN-Ag-RP) | 5 | UniProt NCBI |
| KRT4 | Keratin, type II cytoskeletal 4 (Cytokeratin-4) (CK-4) (Keratin-4) (K4) (Type-II keratin Kb4) | 5 | UniProt NCBI |
| PRMT5 | Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed] | 5 | UniProt NCBI |
| COPRS | Coordinator of PRMT5 and differentiation stimulator (Cooperator of PRMT5) (Protein TTP1) | 5 | UniProt NCBI |
| FARP2 | FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) | 5 | UniProt NCBI |
| RIOK1 | Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (EC 3.6.3.-) (RIO kinase 1) | 5 | UniProt NCBI |
| WDR77 | Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50) | 5 | UniProt NCBI |
| RENBP | N-acylglucosamine 2-epimerase (AGE) (EC 5.1.3.8) (GlcNAc 2-epimerase) (N-acetyl-D-glucosamine 2-epimerase) (Renin-binding protein) (RnBP) | 5 | UniProt NCBI |
| CIRBP | Cold-inducible RNA-binding protein (A18 hnRNP) (Glycine-rich RNA-binding protein CIRP) | 5 | UniProt NCBI |
| ADCYAP1 | Pituitary adenylate cyclase-activating polypeptide (PACAP) [Cleaved into: PACAP-related peptide (PRP-48); Pituitary adenylate cyclase-activating polypeptide 27 (PACAP-27) (PACAP27); Pituitary adenylate cyclase-activating polypeptide 38 (PACAP-38) (PACAP38)] | 5 | UniProt NCBI |
| PPP1R14A | Protein phosphatase 1 regulatory subunit 14A (17 kDa PKC-potentiated inhibitory protein of PP1) (Protein kinase C-potentiated inhibitor protein of 17 kDa) (CPI-17) | 4 | UniProt NCBI |
| C1orf115 | Required for drug-induced death protein 1 | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6853 | 3.75927585468e-05 | 0.166666666667 | PRMT5 COPRS | COPRS-PRMT5 complex |
| CORUM:837 | 0.000112726824524 | 0.166666666667 | PRMT5 WDR77 | MEP50-PRMT5-ICLN complex |
| CORUM:2838 | 0.000112726824524 | 0.166666666667 | PRMT5 WDR77 | MEP50-PRMT5-ICLN complex |
| CORUM:6852 | 0.000225350794349 | 0.166666666667 | PRMT5 COPRS | COPRS-PRMT5-RUNX1-CBFB complex |
| CORUM:6858 | 0.000375413311943 | 0.166666666667 | PRMT5 WDR77 | CHTOP-methylosome complex |
| CORUM:810 | 0.00078764880341 | 0.166666666667 | PRMT5 WDR77 | FCP1-associated protein complex |
| CORUM:811 | 0.00078764880341 | 0.166666666667 | PRMT5 WDR77 | FCP1-associated protein complex |
| REAC:R-HSA-3214858 | 0.00584044581838 | 0.25 | WDR77 PRMT5 COPRS | RMTs methylate histone arginines |
| GO:0048026 | 0.0203399151593 | 0.25 | CIRBP PRMT5 WDR77 | positive regulation of mRNA splicing, via spliceosome |
| GO:0050685 | 0.0423869429414 | 0.25 | CIRBP PRMT5 WDR77 | positive regulation of mRNA processing |
| CORUM:1748 | 0.0499436884912 | 0.0833333333333 | PRMT5 | PRMT5 complex |
| CORUM:2764 | 0.0499436884912 | 0.0833333333333 | PRMT5 | PRMT5 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| COPRS | WDR77 | 0.999 | 0.156 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM boldt_WMM WMM_only | |
| PRMT5 | WDR77 | 0.999 | 0.914 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| COPRS | RIOK1 | 0.999 | 0.068 |
mutually_exclusive (O14744)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM boldt_WMM WMM_only |
| COPRS | PRMT5 | 0.996 | 0.132 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM boldt_WMM |
| PRMT5 | RIOK1 | 0.994 | 0.214 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM boldt_WMM |
| RIOK1 | WDR77 | 0.994 | 0.196 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| CIRBP | WDR77 | 0.993 | 0.022 |
structurally_consistent (O14744)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RENBP | TINAGL1 | 0.984 | 0.074 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| COPRS | FARP2 | 0.983 | 0.164 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| COPRS | CIRBP | 0.981 | 0.032 |
structurally_consistent (O14744)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CIRBP | PRMT5 | 0.971 | 0.068 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| RIOK1 | TINAGL1 | 0.965 | 0.04 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| FARP2 | PRMT5 | 0.963 | 0.18 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CIRBP | RIOK1 | 0.963 | 0.03 |
structurally_consistent (O14744)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| FARP2 | WDR77 | 0.958 | 0.102 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| COPRS | ADCYAP1 | 0.939 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| COPRS | C1orf115 | 0.929 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| WDR77 | TINAGL1 | 0.916 | 0.064 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| FARP2 | RIOK1 | 0.9 | 0.11 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| WDR77 | PPP1R14A | 0.885 | 0.082 |
mixed_interface
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
| WDR77 | KRT4 | 0.858 | 0.022 | bioplex3_HEK293 WMM_only boldt_WMM | |
| ADCYAP1 | WDR77 | 0.853 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PRMT5 | TINAGL1 | 0.846 | 0.034 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ADCYAP1 | PRMT5 | 0.833 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| C1orf115 | PRMT5 | 0.745 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| PRMT5 | PPP1R14A | 0.745 | 0.084 |
mixed_interface
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
| C1orf115 | WDR77 | 0.643 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| RIOK1 | PPP1R14A | 0.533 | 0.1 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| C1orf115 | RIOK1 | 0.264 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| WDR77 | RENBP | 0.211 | 0.062 | bioplex_WMM bioplex3_WMM WMM_only | |
| PRMT5 | KRT4 | 0.204 | 0.08 | bioplex3_HEK293 WMM_only boldt_WMM | |
| RIOK1 | RENBP | 0.161 | 0.04 | bioplex_WMM bioplex3_WMM WMM_only | |
| PRMT5 | RENBP | 0.129 | 0.072 | bioplex_WMM bioplex3_WMM WMM_only | |
| CIRBP | PPP1R14A | 0.01 | 0.05 | bioplex3_HEK293 WMM_only | |
| RIOK1 | KRT4 | 0.009 | 0.03 | WMM_only boldt_WMM | |
| CIRBP | ADCYAP1 | 0.008 | bioplex3_HEK293 bioplex () | ||
| CIRBP | KRT4 | 0.004 | 0.016 | bioplex3_HEK293 WMM_only | |
| FARP2 | CIRBP | 0.002 | 0.062 | bioplex3_HEK293 bioplex () bioplex3_WMM |
Related Complexes