hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_15253.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RTL9 | Retrotransposon Gag-like protein 9 (Retrotransposon gag domain-containing protein 1) (Tumor antigen BJ-HCC-23) | 2 | UniProt NCBI |
| UGT1A8 | UDP-glucuronosyltransferase 1A8 (UGT1A8) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-8) (UDPGT 1-8) (UGT1*8) (UGT1-08) (UGT1.8) (UDP-glucuronosyltransferase 1-H) (UGT-1H) (UGT1H) | 5 | UniProt NCBI |
| UGT1A10 | UDP-glucuronosyltransferase 1A10 (UGT1A10) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-10) (UDPGT 1-10) (UGT1*10) (UGT1-10) (UGT1.10) (UDP-glucuronosyltransferase 1-J) (UGT-1J) (UGT1J) | 5 | UniProt NCBI |
| UGT1A9 | UDP-glucuronosyltransferase 1A9 (UGT1A9) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-9) (UDPGT 1-9) (UGT1*9) (UGT1-09) (UGT1.9) (UDP-glucuronosyltransferase 1-I) (UGT-1I) (UGT1I) (lugP4) | 5 | UniProt NCBI |
| UGT1A7 | UDP-glucuronosyltransferase 1A7 (UGT1A7) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-7) (UDPGT 1-7) (UGT1*7) (UGT1-07) (UGT1.7) (UDP-glucuronosyltransferase 1-G) (UGT-1G) (UGT1G) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0051552 | 1.31563155046e-10 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | flavone metabolic process |
| WP:WP698 | 5.05370170799e-10 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | Glucuronidation |
| REAC:R-HSA-156588 | 7.76907848915e-10 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | Glucuronidation |
| KEGG:00053 | 9.33433002566e-10 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | Ascorbate and aldarate metabolism |
| KEGG:00040 | 1.61394203707e-09 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | Pentose and glucuronate interconversions |
| GO:0009812 | 4.60395405777e-09 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | flavonoid metabolic process |
| KEGG:00860 | 5.21846217478e-09 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | Porphyrin metabolism |
| KEGG:00140 | 1.16503464997e-08 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | Steroid hormone biosynthesis |
| KEGG:00830 | 3.18378883769e-08 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | Retinol metabolism |
| KEGG:05204 | 3.73025454511e-08 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | Chemical carcinogenesis - DNA adducts |
| KEGG:00982 | 4.0284537322e-08 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | Drug metabolism - cytochrome P450 |
| KEGG:04976 | 5.40322943081e-08 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | Bile secretion |
| KEGG:00980 | 5.79587326968e-08 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | Metabolism of xenobiotics by cytochrome P450 |
| KEGG:00983 | 9.75657108053e-08 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | Drug metabolism - other enzymes |
| GO:0052695 | 1.31622611039e-07 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | cellular glucuronidation |
| WP:WP1604 | 1.44800475023e-07 | 0.6 | UGT1A8 UGT1A10 UGT1A9 | Codeine and morphine metabolism |
| GO:0006063 | 1.79475545894e-07 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | uronic acid metabolic process |
| GO:0019585 | 1.79475545894e-07 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | glucuronate metabolic process |
| REAC:R-HSA-156580 | 6.72765558294e-07 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | Phase II - Conjugation of compounds |
| REAC:R-HSA-9748784 | 7.07675506867e-07 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | Drug ADME |
| WP:WP5224 | 7.85708871164e-07 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | 2q37 copy number variation syndrome |
| GO:0015020 | 1.396459195e-06 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | glucuronosyltransferase activity |
| KEGG:01240 | 1.62849020198e-06 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | Biosynthesis of cofactors |
| KEGG:05207 | 3.58869764368e-06 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | Chemical carcinogenesis - receptor activation |
| GO:0052696 | 3.84440695359e-06 | 0.6 | UGT1A8 UGT1A7 UGT1A9 | flavonoid glucuronidation |
| GO:0001889 | 8.67338862712e-06 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | liver development |
| GO:0061008 | 9.69325556185e-06 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | hepaticobiliary system development |
| REAC:R-HSA-211859 | 1.2001164198e-05 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | Biological oxidations |
| REAC:R-HSA-9749641 | 1.26352756558e-05 | 0.6 | UGT1A8 UGT1A7 UGT1A9 | Aspirin ADME |
| GO:0052697 | 1.92180881975e-05 | 0.6 | UGT1A8 UGT1A7 UGT1A9 | xenobiotic glucuronidation |
| GO:0042440 | 3.27930250282e-05 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | pigment metabolic process |
| GO:0001972 | 0.000274621184043 | 0.6 | UGT1A8 UGT1A7 UGT1A9 | retinoic acid binding |
| GO:0006805 | 0.00029151492518 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | xenobiotic metabolic process |
| WP:WP229 | 0.00032310719867 | 0.4 | UGT1A9 UGT1A10 | Irinotecan pathway |
| WP:WP702 | 0.000477678931024 | 0.6 | UGT1A9 UGT1A10 UGT1A7 | Metapathway biotransformation Phase I and II |
| WP:WP691 | 0.000534376000489 | 0.4 | UGT1A8 UGT1A10 | Tamoxifen metabolism |
| GO:0071466 | 0.000727710984203 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | cellular response to xenobiotic stimulus |
| GO:0048732 | 0.000842045360476 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | gland development |
| GO:0008194 | 0.000904012985399 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | UDP-glycosyltransferase activity |
| WP:WP5276 | 0.00123199381981 | 0.4 | UGT1A8 UGT1A10 | Estrogen metabolism |
| GO:0005501 | 0.00127603542925 | 0.6 | UGT1A8 UGT1A7 UGT1A9 | retinoid binding |
| GO:0019840 | 0.00127603542925 | 0.6 | UGT1A8 UGT1A7 UGT1A9 | isoprenoid binding |
| GO:0009410 | 0.00206012733421 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | response to xenobiotic stimulus |
| GO:0042573 | 0.00220577099344 | 0.6 | UGT1A8 UGT1A7 UGT1A9 | retinoic acid metabolic process |
| GO:0016758 | 0.00317794363223 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | hexosyltransferase activity |
| REAC:R-HSA-9753281 | 0.00350190276731 | 0.4 | UGT1A9 UGT1A10 | Paracetamol ADME |
| WP:WP2873 | 0.00389862536801 | 0.4 | UGT1A9 UGT1A7 | Aryl hydrocarbon receptor pathway |
| GO:0046982 | 0.0042756506291 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | protein heterodimerization activity |
| GO:0016757 | 0.01125755688 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | glycosyltransferase activity |
| KEGG:01100 | 0.0139298332568 | 0.8 | UGT1A8 UGT1A10 UGT1A7 UGT1A9 | Metabolic pathways |
| TF:M09875 | 0.0209786718727 | 1.0 | UGT1A8 UGT1A7 RTL9 UGT1A9 UGT1A10 | Factor: BHLHA15; motif: SNAGCAGCTGG |
| GO:0033293 | 0.0279690439474 | 0.6 | UGT1A8 UGT1A7 UGT1A9 | monocarboxylic acid binding |
| GO:0001523 | 0.0279690439474 | 0.6 | UGT1A8 UGT1A7 UGT1A9 | retinoid metabolic process |
| GO:0016101 | 0.0310683011928 | 0.6 | UGT1A8 UGT1A7 UGT1A9 | diterpenoid metabolic process |
| WP:WP2884 | 0.0360146352745 | 0.4 | UGT1A9 UGT1A7 | NRF2 pathway |
| GO:0006721 | 0.0457443058639 | 0.6 | UGT1A8 UGT1A7 UGT1A9 | terpenoid metabolic process |
| GO:0009698 | 0.0468008499735 | 0.4 | UGT1A8 UGT1A7 | phenylpropanoid metabolic process |
| GO:0009804 | 0.0468008499735 | 0.4 | UGT1A8 UGT1A7 | coumarin metabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| UGT1A7 | UGT1A10 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RTL9 | UGT1A7 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| UGT1A7 | UGT1A9 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| UGT1A10 | UGT1A9 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| UGT1A8 | UGT1A7 | 0.972 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| RTL9 | UGT1A9 | 0.946 | bioplex3_WMM WMM_only | |
| UGT1A8 | UGT1A9 | 0.415 | bioplex3_WMM WMM_only | |
| RTL9 | UGT1A10 | 0.415 | bioplex3_WMM WMM_only | |
| RTL9 | UGT1A8 | 0.415 | bioplex3_WMM WMM_only | |
| UGT1A8 | UGT1A10 | 0.415 | bioplex3_WMM WMM_only |
Related Complexes