hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_15270.1

Complex Portal: CPX-24709

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
NPRL2	GATOR1 complex protein NPRL2 (Gene 21 protein) (G21 protein) (Nitrogen permease regulator 2-like protein) (NPR2-like protein) (Tumor suppressor candidate 4)	5	UniProt NCBI
KPTN	KICSTOR complex protein kaptin (Actin-associated protein 2E4)	5	UniProt NCBI
ITFG2	KICSTOR complex protein ITFG2 (Integrin-alpha FG-GAP repeat-containing protein 2)	5	UniProt NCBI
NPRL3	GATOR1 complex protein NPRL3 (-14 gene protein) (Alpha-globin regulatory element-containing gene protein) (Nitrogen permease regulator 3-like protein) (Protein CGTHBA)	5	UniProt NCBI
KICS2	KICSTOR subunit 2 (KICSTOR complex protein C12orf66)	5	UniProt NCBI
TMCO4	Transmembrane and coiled-coil domain-containing protein 4	3	UniProt NCBI
BMT2	S-adenosylmethionine sensor upstream of mTORC1 (Probable methyltransferase BMT2 homolog) (EC 2.1.1.-)	5	UniProt NCBI
SZT2	KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog)	5	UniProt NCBI
DEPDC5	GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-9639288	3.65841672346e-17	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	Amino acids regulate mTORC1
GO:1904262	1.02865147301e-15	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	negative regulation of TORC1 signaling
GO:0034198	1.26369474516e-15	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	cellular response to amino acid starvation
GO:1990928	1.87823605092e-15	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	response to amino acid starvation
GO:0032007	1.93055751129e-14	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	negative regulation of TOR signaling
REAC:R-HSA-9711097	2.53655309533e-13	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	Cellular response to starvation
GO:1903432	4.18312868331e-13	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	regulation of TORC1 signaling
GO:0038202	6.13746012193e-13	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	TORC1 signaling
CORUM:6754	5.38212907005e-12	0.444444444444	KICS2 SZT2 KPTN ITFG2	KICSTOR complex
GO:0009267	6.80272023242e-12	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	cellular response to starvation
GO:0032006	9.54653229711e-12	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	regulation of TOR signaling
GO:0042594	2.03922649389e-11	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	response to starvation
GO:0031929	2.29868139551e-11	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	TOR signaling
GO:0031669	8.11836159901e-11	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	cellular response to nutrient levels
GO:0031668	1.26571625562e-10	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	cellular response to extracellular stimulus
GO:0071496	5.5863887384e-10	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	cellular response to external stimulus
GO:0031667	9.94084786068e-10	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	response to nutrient levels
GO:0009991	1.47949977609e-09	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	response to extracellular stimulus
GO:0140007	3.31539150715e-09	0.444444444444	KICS2 SZT2 KPTN ITFG2	KICSTOR complex
CORUM:6215	1.31072783286e-08	0.333333333333	NPRL2 NPRL3 DEPDC5	GATOR1 complex
GO:1990130	1.65724193228e-08	0.444444444444	NPRL2 DEPDC5 NPRL3 SZT2	GATOR1 complex
REAC:R-HSA-2262752	7.05148732353e-08	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	Cellular responses to stress
REAC:R-HSA-8953897	7.61598662912e-08	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	Cellular responses to stimuli
GO:1902532	1.07528888059e-07	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	negative regulation of intracellular signal transduction
CORUM:6753	7.32877958003e-07	0.333333333333	NPRL2 NPRL3 SZT2	SOG complex
CORUM:6217	7.32877958003e-07	0.333333333333	NPRL2 NPRL3 DEPDC5	GATOR complex
GO:0035859	2.3646695756e-06	0.444444444444	NPRL2 DEPDC5 NPRL3 SZT2	Seh1-associated complex
HP:0012005	2.93331849512e-06	0.333333333333	NPRL2 NPRL3 DEPDC5	Deja vu aura
HP:0032680	2.93331849512e-06	0.333333333333	NPRL2 NPRL3 DEPDC5	Focal cognitive seizure
HP:0012004	2.93331849512e-06	0.333333333333	NPRL2 NPRL3 DEPDC5	Focal cognitive seizure with deja vu/jamais vu
GO:0098852	4.46590042025e-06	0.777777777778	KICS2 ITFG2 NPRL2 KPTN DEPDC5 SZT2 NPRL3	lytic vacuole membrane
GO:0005765	4.46590042025e-06	0.777777777778	KICS2 ITFG2 NPRL2 KPTN DEPDC5 SZT2 NPRL3	lysosomal membrane
HP:0008765	5.13172631979e-06	0.333333333333	NPRL2 NPRL3 DEPDC5	Auditory hallucination
GO:0005774	7.65416784362e-06	0.777777777778	KICS2 ITFG2 NPRL2 KPTN DEPDC5 SZT2 NPRL3	vacuolar membrane
HP:0012002	1.23085572601e-05	0.333333333333	NPRL2 NPRL3 DEPDC5	Experiential epileptic aura
HP:0033346	1.23085572601e-05	0.333333333333	NPRL2 NPRL3 DEPDC5	Psychic epileptic aura
HP:0033259	2.28095717142e-05	0.555555555556	NPRL2 DEPDC5 SZT2 KPTN NPRL3	Non-motor seizure
HP:0002427	2.41626304595e-05	0.333333333333	NPRL2 NPRL3 DEPDC5	Expressive aphasia
HP:0031951	5.32549795307e-05	0.333333333333	NPRL2 NPRL3 DEPDC5	Nocturnal seizures
HP:0032046	5.32549795307e-05	0.333333333333	NPRL2 NPRL3 DEPDC5	Focal cortical dysplasia
HP:0007206	5.32549795307e-05	0.333333333333	NPRL2 NPRL3 DEPDC5	Hemimegalencephaly
HP:0011146	6.53790773438e-05	0.555555555556	NPRL2 DEPDC5 SZT2 KPTN NPRL3	Dialeptic seizure
HP:0002367	6.6548215792e-05	0.333333333333	NPRL2 NPRL3 DEPDC5	Visual hallucination
GO:0009968	7.3411791618e-05	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	negative regulation of signal transduction
GO:0010648	9.49880523634e-05	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	negative regulation of cell communication
GO:0023057	0.000100085582019	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	negative regulation of signaling
HP:0033348	0.00014155117386	0.333333333333	NPRL2 NPRL3 DEPDC5	Epileptic aura
HP:0011171	0.000194166208877	0.333333333333	NPRL2 NPRL3 DEPDC5	Simple febrile seizure
HP:0002349	0.000194166208877	0.333333333333	NPRL2 NPRL3 DEPDC5	Focal aware seizure
GO:0000323	0.000230918914391	0.777777777778	KICS2 ITFG2 NPRL2 KPTN DEPDC5 SZT2 NPRL3	lytic vacuole
GO:0005764	0.000230918914391	0.777777777778	KICS2 ITFG2 NPRL2 KPTN DEPDC5 SZT2 NPRL3	lysosome
GO:0042149	0.000300019348538	0.444444444444	KICS2 SZT2 KPTN ITFG2	cellular response to glucose starvation
HP:0032052	0.000306458653145	0.222222222222	NPRL3 DEPDC5	Focal cortical dysplasia type IIa
GO:0048585	0.000438043903742	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	negative regulation of response to stimulus
GO:0005773	0.000451782097262	0.777777777778	KICS2 ITFG2 NPRL2 KPTN DEPDC5 SZT2 NPRL3	vacuole
HP:0002069	0.000596511392267	0.555555555556	NPRL2 DEPDC5 SZT2 KPTN NPRL3	Bilateral tonic-clonic seizure
HP:0032679	0.000870108028777	0.333333333333	NPRL2 NPRL3 DEPDC5	Focal non-motor seizure
GO:1902531	0.000962212397551	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	regulation of intracellular signal transduction
HP:0001355	0.00112875806168	0.333333333333	NPRL2 NPRL3 DEPDC5	Megalencephaly
HP:0002521	0.00137243675422	0.444444444444	NPRL2 DEPDC5 NPRL3 SZT2	Hypsarrhythmia
GO:0033554	0.00149848056513	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	cellular response to stress
HP:0031284	0.00191982416351	0.333333333333	NPRL2 NPRL3 DEPDC5	Flushing
WP:WP4657	0.00231220241685	0.333333333333	NPRL2 NPRL3 DEPDC5	22q11 2 copy number variation syndrome
HP:0002539	0.00301223952387	0.333333333333	NPRL2 NPRL3 DEPDC5	Cortical dysplasia
HP:0002353	0.0030199612325	0.555555555556	NPRL2 DEPDC5 SZT2 KPTN NPRL3	EEG abnormality
HP:0032051	0.00306165140522	0.222222222222	NPRL3 DEPDC5	Focal cortical dysplasia type II
HP:0030178	0.0040853309684	0.555555555556	NPRL2 DEPDC5 SZT2 KPTN NPRL3	Abnormality of central nervous system electrophysiology
KEGG:04150	0.00413269570012	0.333333333333	NPRL2 NPRL3 DEPDC5	mTOR signaling pathway
GO:0009605	0.00469810130268	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	response to external stimulus
HP:0000729	0.00517462691203	0.555555555556	NPRL2 DEPDC5 SZT2 KPTN NPRL3	Autistic behavior
HP:0010841	0.00518974778476	0.333333333333	NPRL2 NPRL3 DEPDC5	Multifocal epileptiform discharges
HP:0011198	0.00677285226033	0.444444444444	NPRL2 DEPDC5 NPRL3 SZT2	EEG with generalized epileptiform discharges
HP:0001311	0.00899302393028	0.555555555556	NPRL2 DEPDC5 SZT2 KPTN NPRL3	Abnormal nervous system electrophysiology
HP:0011182	0.0128560667408	0.444444444444	NPRL2 DEPDC5 NPRL3 SZT2	Interictal epileptiform activity
HP:0025373	0.0134204673809	0.444444444444	NPRL2 DEPDC5 NPRL3 SZT2	Interictal EEG abnormality
HP:0002381	0.0136427038396	0.333333333333	NPRL2 NPRL3 DEPDC5	Aphasia
HP:0007359	0.0150151918753	0.444444444444	NPRL2 DEPDC5 NPRL3 SZT2	Focal-onset seizure
GO:0035556	0.0214945809649	0.888888888889	KICS2 SZT2 NPRL2 KPTN BMT2 DEPDC5 ITFG2 NPRL3	intracellular signal transduction
HP:0002384	0.022353712526	0.333333333333	NPRL2 NPRL3 DEPDC5	Focal impaired awareness seizure
HP:0011185	0.0266668186122	0.333333333333	NPRL2 NPRL3 DEPDC5	EEG with focal epileptiform discharges
HP:0003401	0.03235230965	0.333333333333	NPRL2 NPRL3 DEPDC5	Paresthesia
HP:0032892	0.0350146609279	0.333333333333	NPRL2 NPRL3 DEPDC5	Infection-related seizure
HP:0032894	0.0350146609279	0.333333333333	NPRL2 NPRL3 DEPDC5	Seizure precipitated by febrile infection
HP:0002373	0.0350146609279	0.333333333333	NPRL2 NPRL3 DEPDC5	Febrile seizure (within the age range of 3 months to 6 years)
HP:0003829	0.0428099509923	0.333333333333	NPRL2 NPRL3 DEPDC5	Typified by incomplete penetrance
HP:0020219	0.0455154719118	0.444444444444	NPRL2 DEPDC5 NPRL3 SZT2	Motor seizure

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
KPTN	ITFG2	1.0	0.234	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
NPRL2	DEPDC5	1.0	0.138		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
SZT2	ITFG2	1.0	0.156		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
KPTN	SZT2	1.0	0.17		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
KICS2	ITFG2	0.999	0.134		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
NPRL2	NPRL3	0.999	0.138		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
KPTN	TMCO4	0.999	0.082	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
KPTN	KICS2	0.999	0.082		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
BMT2	SZT2	0.997			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
BMT2	DEPDC5	0.997			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
BMT2	KICS2	0.996			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
DEPDC5	NPRL3	0.996	0.118		bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
NPRL2	BMT2	0.995			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
KICS2	SZT2	0.989	0.066		bioplex_WMM bioplex3_WMM WMM_only
BMT2	ITFG2	0.987		structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
BMT2	NPRL3	0.98			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
KPTN	NPRL3	0.978	0.222		bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
NPRL2	ITFG2	0.978	0.15		bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
ITFG2	TMCO4	0.967	0.124	structurally_consistent (Q9Y664)	bioplex_WMM bioplex3_WMM WMM_only
SZT2	TMCO4	0.962	0.132		bioplex_WMM bioplex3_WMM WMM_only
KICS2	TMCO4	0.961	0.064		bioplex_WMM bioplex3_WMM WMM_only
DEPDC5	ITFG2	0.959	0.108		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
KPTN	BMT2	0.933		structurally_consistent (Q969R8) structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
ITFG2	NPRL3	0.92	0.178		bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
KPTN	NPRL2	0.657	0.142		bioplex_WMM bioplex3_WMM WMM_only
NPRL2	SZT2	0.65	0.104		bioplex_WMM bioplex3_WMM WMM_only
NPRL2	KICS2	0.648	0.104		bioplex_WMM bioplex3_WMM WMM_only
KICS2	NPRL3	0.636	0.114		bioplex_WMM bioplex3_WMM WMM_only
KPTN	DEPDC5	0.606	0.068		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
SZT2	NPRL3	0.6	0.156		bioplex_WMM bioplex3_WMM WMM_only
DEPDC5	KICS2	0.576	0.112		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
DEPDC5	SZT2	0.247	0.202		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
TMCO4	NPRL3	0.016	0.134		bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
NPRL2	huMAP3_03530.1 huMAP3_07128.1 huMAP3_08734.1 huMAP3_09179.1 huMAP3_10405.1 huMAP3_13864.1 huMAP3_15270.1
KPTN	huMAP3_00925.1 huMAP3_03857.1 huMAP3_05863.1 huMAP3_06146.1 huMAP3_06545.1 huMAP3_07900.1 huMAP3_09557.1 huMAP3_10405.1 huMAP3_10779.1 huMAP3_13864.1 huMAP3_15270.1
ITFG2	huMAP3_04172.1 huMAP3_07402.1 huMAP3_08734.1 huMAP3_09179.1 huMAP3_10405.1 huMAP3_13864.1 huMAP3_15270.1
NPRL3	huMAP3_07128.1 huMAP3_08734.1 huMAP3_09179.1 huMAP3_10405.1 huMAP3_13864.1 huMAP3_15270.1
KICS2	huMAP3_04172.1 huMAP3_07402.1 huMAP3_08734.1 huMAP3_09557.1 huMAP3_10405.1 huMAP3_13864.1 huMAP3_15270.1
TMCO4	huMAP3_04172.1 huMAP3_06146.1 huMAP3_06545.1 huMAP3_09557.1 huMAP3_10405.1 huMAP3_13864.1 huMAP3_15270.1
BMT2	huMAP3_03530.1 huMAP3_07128.1 huMAP3_08734.1 huMAP3_09179.1 huMAP3_10405.1 huMAP3_13864.1 huMAP3_15270.1
SZT2	huMAP3_04172.1 huMAP3_07402.1 huMAP3_08734.1 huMAP3_09557.1 huMAP3_10405.1 huMAP3_13864.1 huMAP3_15270.1
DEPDC5	huMAP3_03530.1 huMAP3_07128.1 huMAP3_08734.1 huMAP3_09179.1 huMAP3_10405.1 huMAP3_13864.1 huMAP3_15270.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_15270.1

Complex Portal: CPX-24709