hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_15295.1
Complex Portal: CPX-16615
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PPIA | Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed] | 5 | UniProt NCBI |
| MYH14 | Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) | 5 | UniProt NCBI |
| FBXO40 | F-box only protein 40 (Muscle disease-related protein) | 4 | UniProt NCBI |
| MYH9 | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | 5 | UniProt NCBI |
| SYNPO | Synaptopodin | 5 | UniProt NCBI |
| MYL3 | Myosin light chain 3 (Cardiac myosin light chain 1) (CMLC1) (Myosin light chain 1, slow-twitch muscle B/ventricular isoform) (MLC1SB) (Ventricular myosin alkali light chain) (Ventricular myosin light chain 1) (VLCl) (Ventricular/slow twitch myosin alkali light chain) (MLC-lV/sb) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04530 | 0.000853506949441 | 0.5 | SYNPO MYH14 MYH9 | Tight junction |
| KEGG:04814 | 0.00135053284488 | 0.5 | MYH14 MYL3 MYH9 | Motor proteins |
| GO:0016460 | 0.00339409783315 | 0.5 | MYH14 MYL3 MYH9 | myosin II complex |
| REAC:R-HSA-5627117 | 0.00440152140132 | 0.333333333333 | MYH14 MYH9 | RHO GTPases Activate ROCKs |
| REAC:R-HSA-5625900 | 0.00440152140132 | 0.333333333333 | MYH14 MYH9 | RHO GTPases activate CIT |
| REAC:R-HSA-416572 | 0.00440152140132 | 0.333333333333 | MYH14 MYH9 | Sema4D induced cell migration and growth-cone collapse |
| REAC:R-HSA-5627123 | 0.00488968644054 | 0.333333333333 | MYH14 MYH9 | RHO GTPases activate PAKs |
| REAC:R-HSA-400685 | 0.00650743774508 | 0.333333333333 | MYH14 MYH9 | Sema4D in semaphorin signaling |
| WP:WP4758 | 0.00666790414994 | 0.333333333333 | SYNPO MYH9 | Nephrotic syndrome |
| REAC:R-HSA-3928663 | 0.00835477835936 | 0.333333333333 | MYH14 MYH9 | EPHA-mediated growth cone collapse |
| GO:0016459 | 0.00949259421943 | 0.5 | MYH14 MYL3 MYH9 | myosin complex |
| WP:WP2572 | 0.0188461436964 | 0.333333333333 | SYNPO MYH9 | Primary focal segmental glomerulosclerosis FSGS |
| GO:0097513 | 0.0210651876021 | 0.333333333333 | MYH14 MYH9 | myosin II filament |
| KEGG:04270 | 0.0325874784997 | 0.333333333333 | MYH14 MYH9 | Vascular smooth muscle contraction |
| REAC:R-HSA-373755 | 0.0437202891307 | 0.333333333333 | MYH14 MYH9 | Semaphorin interactions |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MYH9 | MYL3 | 0.998 | 0.564 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MYH9 | FBXO40 | 0.972 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| MYH9 | SYNPO | 0.969 | hein_WMM hein () | ||
| FBXO40 | MYH14 | 0.963 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| MYH14 | MYL3 | 0.947 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| MYH9 | PPIA | 0.935 | 0.616 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM | |
| MYH9 | MYH14 | 0.518 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only boldt_WMM treiber_WMM | ||
| SYNPO | PPIA | 0.034 | hein_WMM WMM_only | ||
| MYH14 | PPIA | 0.006 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only boldt_WMM treiber_WMM | ||
| MYL3 | PPIA | 0.002 | 0.1028 | bioplex3_HEK293 bioplex () bioplex3_HCT116 | |
| FBXO40 | PPIA | 0.001 | bioplex3_HEK293 bioplex () bioplex3_HCT116 |
Related Complexes