hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_15298.1
Complex Portal: CPX-13783
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DMC1 | Meiotic recombination protein DMC1/LIM15 homolog | 5 | UniProt NCBI |
| FYN | Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) | 5 | UniProt NCBI |
| ACTA1 | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | 5 | UniProt NCBI |
| CLDN20 | Claudin-20 | 5 | UniProt NCBI |
| RAD51 | DNA repair protein RAD51 homolog 1 (HsRAD51) (hRAD51) (RAD51 homolog A) | 5 | UniProt NCBI |
| FAM135B | Protein FAM135B | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP34 | 0.00436073489596 | 0.333333333333 | DMC1 RAD51 | Ovarian infertility |
| GO:0000150 | 0.00702301080125 | 0.333333333333 | DMC1 RAD51 | DNA strand exchange activity |
| GO:0000730 | 0.0210651876021 | 0.333333333333 | DMC1 RAD51 | DNA recombinase assembly |
| GO:0090735 | 0.0210651876021 | 0.333333333333 | DMC1 RAD51 | DNA repair complex assembly |
| CORUM:2321 | 0.0499436884912 | 0.166666666667 | FYN | ITGA6-ITGB4-FYN complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DMC1 | RAD51 | 0.977 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CLDN20 | ACTA1 | 0.971 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| DMC1 | ACTA1 | 0.943 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ACTA1 | FYN | 0.928 | 0.168 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| FAM135B | FYN | 0.905 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CLDN20 | FYN | 0.851 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| RAD51 | ACTA1 | 0.052 | 0.12 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| RAD51 | FYN | 0.003 | 0.098 | bioplex3_WMM WMM_only |
Related Complexes