hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_15305.1

Complex Portal: CPX-17262

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
COLGALT2	Procollagen galactosyltransferase 2 (EC 2.4.1.50) (Collagen beta(1-O)galactosyltransferase 2) (ColGalT 2) (Glycosyltransferase 25 family member 2) (Hydroxylysine galactosyltransferase 2)	5	UniProt NCBI
VPS33B	Vacuolar protein sorting-associated protein 33B (hVPS33B)	5	UniProt NCBI
DOK1	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)	5	UniProt NCBI
COL9A2	Collagen alpha-2(IX) chain	5	UniProt NCBI
VIPAS39	Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction)	5	UniProt NCBI
COL9A3	Collagen alpha-3(IX) chain	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:6390	1.70876175213e-05	0.333333333333	VPS33B VIPAS39	Endosomal targeting complex (VIPAS39-VPS33B)
HPA:0200273	4.16308055378e-05	0.333333333333	COL9A3 COL9A2	eye; hyaloid membrane[High]
HPA:0200272	8.32464165711e-05	0.333333333333	COL9A3 COL9A2	eye; hyaloid membrane[>=Medium]
HPA:0200271	8.32464165711e-05	0.333333333333	COL9A3 COL9A2	eye; hyaloid membrane[>=Low]
HPA:0070113	8.32464165711e-05	0.333333333333	COL9A3 COL9A2	cartilage; chondrocytes[High]
WP:WP4789	0.00015103053622	0.333333333333	COL9A3 COL9A2	MED and pseudoachondroplasia genes
REAC:R-HSA-1650814	0.000155019643237	0.5	COLGALT2 COL9A2 COL9A3	Collagen biosynthesis and modifying enzymes
HPA:0070000	0.000291202964835	0.333333333333	COL9A3 COL9A2	cartilage
HPA:0070111	0.000291202964835	0.333333333333	COL9A3 COL9A2	cartilage; chondrocytes[>=Low]
HPA:0070112	0.000291202964835	0.333333333333	COL9A3 COL9A2	cartilage; chondrocytes[>=Medium]
HP:0009189	0.000324079809263	0.333333333333	COL9A3 COL9A2	Fragmentation of the metacarpal epiphyses
HP:0006190	0.000324079809263	0.333333333333	COL9A3 COL9A2	Radially deviated wrists
HP:0012770	0.000324079809263	0.333333333333	COL9A3 COL9A2	Reduced arm span
HP:0003946	0.000324079809263	0.333333333333	COL9A3 COL9A2	Abnormality of the epiphyses of the elbow
HP:0003841	0.000324079809263	0.333333333333	COL9A3 COL9A2	Fragmented epiphyses of the upper limbs
REAC:R-HSA-1474290	0.000417052782963	0.5	COLGALT2 COL9A2 COL9A3	Collagen formation
HP:0006055	0.000648041335154	0.333333333333	COL9A3 COL9A2	Ulnar deviated club hands
HP:0200084	0.000648041335154	0.333333333333	VPS33B VIPAS39	Giant cell hepatitis
HP:0100168	0.00107987178333	0.333333333333	COL9A3 COL9A2	Fragmented epiphyses
HP:0003999	0.00107987178333	0.333333333333	COL9A3 COL9A2	Abnormality of radial epiphyses
HP:0010631	0.00161951205762	0.333333333333	COL9A3 COL9A2	Abnormality of the epiphyses of the feet
HP:0009806	0.00161951205762	0.333333333333	VPS33B VIPAS39	Nephrogenic diabetes insipidus
HPA:0200000	0.00290459637219	0.333333333333	COL9A3 COL9A2	eye
HP:0012769	0.00302198579101	0.333333333333	COL9A3 COL9A2	Abnormal arm span
HP:0003365	0.00302198579101	0.333333333333	COL9A3 COL9A2	Arthralgia of the hip
HP:0009486	0.00388470114881	0.333333333333	COL9A3 COL9A2	Radial deviation of the hand
HP:0001884	0.00485499013014	0.333333333333	VPS33B VIPAS39	Talipes calcaneovalgus
HP:0030973	0.00841070885474	0.333333333333	COL9A3 COL9A2	Postexertional symptom exacerbation
HP:0010665	0.00841070885474	0.333333333333	COL9A3 COL9A2	Bilateral coxa valga
HP:0030839	0.00841070885474	0.333333333333	COL9A3 COL9A2	Knee pain
REAC:R-HSA-419037	0.00902151290218	0.333333333333	COL9A3 COL9A2	NCAM1 interactions
REAC:R-HSA-8948216	0.0111743831709	0.333333333333	COL9A3 COL9A2	Collagen chain trimerization
HP:0003272	0.0126854625769	0.666666666667	VPS33B COL9A2 COL9A3 VIPAS39	Abnormal hip bone morphology
HP:0100694	0.0129324670968	0.333333333333	COL9A3 COL9A2	Tibial torsion
HP:0002611	0.0129324670968	0.333333333333	VPS33B VIPAS39	Cholestatic liver disease
REAC:R-HSA-1474244	0.0133066815994	0.5	COLGALT2 COL9A2 COL9A3	Extracellular matrix organization
HP:0001385	0.0141028469624	0.5	VPS33B COL9A2 VIPAS39	Hip dysplasia
HP:0005913	0.0146541203169	0.333333333333	COL9A3 COL9A2	Abnormal metacarpal epiphysis morphology
KEGG:04512	0.0158846761267	0.333333333333	COL9A3 COL9A2	ECM-receptor interaction
HP:0007773	0.0164828756284	0.333333333333	COL9A3 COL9A2	Vitreoretinopathy
HP:0003502	0.0164828756284	0.333333333333	COL9A3 COL9A2	Mild short stature
HP:0010585	0.0164828756284	0.333333333333	COL9A3 COL9A2	Small epiphyses
KEGG:04974	0.0168484058015	0.333333333333	COL9A3 COL9A2	Protein digestion and absorption
HP:0010582	0.0184186741717	0.333333333333	COL9A3 COL9A2	Irregular epiphyses
HP:0002644	0.0197536366037	0.666666666667	VPS33B COL9A2 COL9A3 VIPAS39	Abnormal pelvic girdle bone morphology
GO:0005594	0.0210651876021	0.333333333333	COL9A3 COL9A2	collagen type IX trimer
REAC:R-HSA-375165	0.0220691409046	0.333333333333	COL9A3 COL9A2	NCAM signaling for neurite out-growth
REAC:R-HSA-2022090	0.0276828753036	0.333333333333	COL9A3 COL9A2	Assembly of collagen fibrils and other multimeric structures
REAC:R-HSA-186797	0.0288812004442	0.333333333333	COL9A3 COL9A2	Signaling by PDGF
HP:0002656	0.0297012565438	0.333333333333	COL9A3 COL9A2	Epiphyseal dysplasia
REAC:R-HSA-1442490	0.0301046858112	0.333333333333	COL9A3 COL9A2	Collagen degradation
HP:0003301	0.0322780794397	0.333333333333	COL9A3 COL9A2	Irregular vertebral endplates
HP:0002908	0.0322780794397	0.333333333333	VPS33B VIPAS39	Conjugated hyperbilirubinemia
HP:0001667	0.0322780794397	0.333333333333	VPS33B VIPAS39	Right ventricular hypertrophy
REAC:R-HSA-3000178	0.0422459670228	0.333333333333	COL9A3 COL9A2	ECM proteoglycans
HP:0009487	0.0436511011886	0.333333333333	COL9A3 COL9A2	Ulnar deviation of the hand
REAC:R-HSA-216083	0.0498675109087	0.333333333333	COL9A3 COL9A2	Integrin cell surface interactions
HP:0005106	0.0499762286031	0.333333333333	COL9A3 COL9A2	Abnormality of the vertebral endplates

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
VPS33B	COLGALT2	0.995	0.06		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
COLGALT2	COL9A3	0.988			bioplex3_WMM bioplex3_HCT116 WMM_only
COLGALT2	COL9A2	0.984			bioplex3_WMM bioplex3_HCT116 WMM_only
VIPAS39	COLGALT2	0.977	0.102		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
COLGALT2	DOK1	0.959	0.11		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
VPS33B	VIPAS39	0.957	0.774	structurally_consistent (dimer)	bioplex_WMM bioplex3_WMM youn_WMM WMM_only
VPS33B	COL9A3	0.633			bioplex3_WMM WMM_only
VPS33B	COL9A2	0.633			bioplex3_WMM WMM_only
VIPAS39	COL9A3	0.633			bioplex3_WMM WMM_only
VIPAS39	COL9A2	0.633			bioplex3_WMM WMM_only
COL9A2	COL9A3	0.616			bioplex3_WMM WMM_only
DOK1	COL9A3	0.214			bioplex3_WMM WMM_only
DOK1	COL9A2	0.214			bioplex3_WMM WMM_only
VIPAS39	DOK1	0.172	0.164		bioplex_WMM bioplex3_WMM WMM_only
VPS33B	DOK1	0.15	0.124		bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
COLGALT2	huMAP3_00858.1 huMAP3_05924.1 huMAP3_06974.1 huMAP3_07149.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10003.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1 huMAP3_15305.1
VPS33B	huMAP3_00004.1 huMAP3_01906.1 huMAP3_06998.1 huMAP3_08196.1 huMAP3_10003.1 huMAP3_10699.1 huMAP3_15305.1
DOK1	huMAP3_00858.1 huMAP3_00870.1 huMAP3_05924.1 huMAP3_08747.1 huMAP3_09119.1 huMAP3_10003.1 huMAP3_10500.1 huMAP3_13038.1 huMAP3_13345.1 huMAP3_14886.1 huMAP3_15305.1
COL9A2	huMAP3_00858.1 huMAP3_02991.1 huMAP3_03159.1 huMAP3_05718.1 huMAP3_05924.1 huMAP3_06974.1 huMAP3_07149.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10003.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1 huMAP3_15305.1
VIPAS39	huMAP3_00004.1 huMAP3_01906.1 huMAP3_06998.1 huMAP3_08196.1 huMAP3_10003.1 huMAP3_10699.1 huMAP3_15305.1
COL9A3	huMAP3_00858.1 huMAP3_02991.1 huMAP3_03159.1 huMAP3_05924.1 huMAP3_06555.1 huMAP3_06974.1 huMAP3_07149.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10003.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1 huMAP3_15305.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_15305.1

Complex Portal: CPX-17262