hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_15323.1

Complex Portal: CPX-19255

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
BMAL2	Basic helix-loop-helix ARNT-like protein 2 (Aryl hydrocarbon receptor nuclear translocator-like protein 2) (Basic-helix-loop-helix-PAS protein MOP9) (Brain and muscle ARNT-like 2) (CYCLE-like factor) (CLIF) (Class E basic helix-loop-helix protein 6) (bHLHe6) (Member of PAS protein 9) (PAS domain-containing protein 9)	5	UniProt NCBI
PDE6B	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta (GMP-PDE beta) (EC 3.1.4.35)	5	UniProt NCBI
CIPC	CLOCK-interacting pacemaker (CLOCK-interacting circadian protein)	5	UniProt NCBI
DHTKD1	2-oxoadipate dehydrogenase complex component E1 (E1a) (OADC-E1) (OADH-E1) (EC 1.2.4.-) (2-oxoadipate dehydrogenase, mitochondrial) (Alpha-ketoadipate dehydrogenase) (Alpha-KADH-E1) (Dehydrogenase E1 and transketolase domain-containing protein 1) (Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial)	5	UniProt NCBI
NPAS2	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Basic-helix-loop-helix-PAS protein MOP4) (Class E basic helix-loop-helix protein 9) (bHLHe9) (Member of PAS protein 4) (PAS domain-containing protein 4)	5	UniProt NCBI
CLOCK	Circadian locomoter output cycles protein kaput (hCLOCK) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 8) (bHLHe8)	5	UniProt NCBI
TDRD9	ATP-dependent RNA helicase TDRD9 (EC 3.6.4.13) (Tudor domain-containing protein 9)	5	UniProt NCBI
BMAL1	Basic helix-loop-helix ARNT-like protein 1 (Aryl hydrocarbon receptor nuclear translocator-like protein 1) (Basic-helix-loop-helix-PAS protein MOP3) (Brain and muscle ARNT-like 1) (Class E basic helix-loop-helix protein 5) (bHLHe5) (Member of PAS protein 3) (PAS domain-containing protein 3) (bHLH-PAS protein JAP3)	5	UniProt NCBI
MSRA	Mitochondrial peptide methionine sulfoxide reductase (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase) (Protein-methionine-S-oxide reductase) (PMSR)	5	UniProt NCBI
PDE6A	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (GMP-PDE alpha) (EC 3.1.4.35) (PDE V-B1)	5	UniProt NCBI
KHDC4	KH homology domain-containing protein 4 (Brings lots of money 7) (Pre-mRNA splicing factor protein KHDC4)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:1990513	5.52565251192e-09	0.4	CLOCK BMAL1 BMAL2 NPAS2	CLOCK-BMAL transcription complex
REAC:R-HSA-1368108	2.3490349375e-07	0.4	CLOCK BMAL1 BMAL2 NPAS2	BMAL1:CLOCK,NPAS2 activates circadian gene expression
WP:WP3594	3.39679428901e-06	0.5	CLOCK CIPC BMAL1 BMAL2 NPAS2	Circadian rhythm genes
GO:0007623	4.93566709462e-06	0.6	CIPC PDE6B BMAL1 CLOCK NPAS2 BMAL2	circadian rhythm
GO:0048511	1.07320527176e-05	0.6	CIPC PDE6B BMAL1 CLOCK NPAS2 BMAL2	rhythmic process
REAC:R-HSA-400253	1.36716025886e-05	0.4	CLOCK BMAL1 BMAL2 NPAS2	Circadian Clock
CORUM:7271	3.07577115383e-05	0.2	NPAS2 BMAL1	ARNTL-NPAS2 complex
CORUM:7272	3.07577115383e-05	0.2	CLOCK BMAL1	Core clock complex
KEGG:04710	4.67042578594e-05	0.3	BMAL1 NPAS2 CLOCK	Circadian rhythm
GO:0042752	6.05657969542e-05	0.5	CLOCK PDE6B BMAL1 BMAL2 CIPC	regulation of circadian rhythm
CORUM:7311	9.22394575203e-05	0.2	CLOCK BMAL1	CRY1-Core clock complex
REAC:R-HSA-9707616	0.000630778022304	0.3	BMAL1 NPAS2 CLOCK	Heme signaling
GO:0051775	0.000644767051209	0.3	BMAL1 NPAS2 CLOCK	response to redox state
WP:WP5205	0.00111161276717	0.3	BMAL1 NPAS2 CLOCK	Clock controlled autophagy in bone metabolism
GO:0042753	0.00138065085968	0.3	BMAL1 BMAL2 CLOCK	positive regulation of circadian rhythm
GO:0032922	0.00246977648377	0.4	CLOCK BMAL1 BMAL2 NPAS2	circadian regulation of gene expression
REAC:R-HSA-1989781	0.00844310669164	0.3	BMAL1 NPAS2 CLOCK	PPARA activates gene expression
REAC:R-HSA-400206	0.00870109711608	0.3	BMAL1 NPAS2 CLOCK	Regulation of lipid metabolism by PPARalpha
WP:WP3298	0.0144252840529	0.2	CLOCK BMAL1	Melatonin metabolism and effects
WP:WP410	0.0335282776025	0.2	CLOCK BMAL1	Exercise induced circadian regulation
WP:WP5348	0.0404201860118	0.2	CLOCK BMAL1	11p11 2 copy number variation syndrome
WP:WP5352	0.0441033585523	0.2	CLOCK BMAL1	10q11 21q11 23 copy number variation syndrome
CORUM:7274	0.0499436884912	0.1	BMAL1	ARNTL-EPAS1 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
NPAS2	BMAL1	0.999			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
BMAL2	NPAS2	0.999		structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
BMAL2	CLOCK	0.999		structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CLOCK	BMAL1	0.998	0.174		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM
CIPC	NPAS2	0.997			bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
NPAS2	CLOCK	0.997		mutually_exclusive (Q8WYA1)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
CIPC	CLOCK	0.997			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
BMAL2	BMAL1	0.997			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PDE6B	CLOCK	0.996			bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
BMAL2	CIPC	0.986			bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CLOCK	KHDC4	0.979	0.32		bioplex3_WMM bioplex3_HCT116 WMM_only
CIPC	BMAL1	0.965			bioplex3_WMM bioplex3_HCT116 WMM_only
BMAL2	MSRA	0.951			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
CLOCK	TDRD9	0.95			bioplex3_HEK293 bioplex3_WMM WMM_only
CLOCK	PDE6A	0.913	0.124		bioplex3_HEK293 bioplex3_WMM WMM_only
PDE6B	BMAL1	0.905			bioplex3_WMM WMM_only
PDE6B	KHDC4	0.904			bioplex3_WMM WMM_only
BMAL1	KHDC4	0.904	0.164		bioplex3_WMM WMM_only
BMAL2	DHTKD1	0.88			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PDE6B	NPAS2	0.795			bioplex3_WMM WMM_only
NPAS2	KHDC4	0.768			bioplex3_WMM WMM_only
PDE6B	PDE6A	0.415			bioplex3_WMM WMM_only
BMAL1	PDE6A	0.415	0.076		bioplex3_WMM WMM_only
TDRD9	PDE6A	0.415			bioplex3_WMM WMM_only
NPAS2	PDE6A	0.415			bioplex3_WMM WMM_only
PDE6B	TDRD9	0.415			bioplex3_WMM WMM_only
BMAL1	TDRD9	0.415			bioplex3_WMM WMM_only
NPAS2	TDRD9	0.274			bioplex3_WMM WMM_only
TDRD9	KHDC4	0.214			bioplex3_WMM WMM_only
PDE6A	KHDC4	0.214	0.088		bioplex3_WMM WMM_only
NPAS2	MSRA	0.172			bioplex_WMM bioplex3_WMM WMM_only
NPAS2	DHTKD1	0.164			bioplex_WMM bioplex3_WMM WMM_only
CLOCK	MSRA	0.143	0.086		bioplex_WMM bioplex3_WMM WMM_only
MSRA	DHTKD1	0.143	0.03		bioplex_WMM bioplex3_WMM WMM_only
CLOCK	DHTKD1	0.138	0.156117647059		bioplex_WMM bioplex3_WMM WMM_only
CIPC	MSRA	0.024			bioplex_WMM WMM_only
CIPC	DHTKD1	0.02			bioplex_WMM WMM_only

Related Complexes

Genename	Complexes
BMAL2	huMAP3_01886.1 huMAP3_12955.1 huMAP3_15323.1
PDE6B	huMAP3_01886.1 huMAP3_12955.1 huMAP3_15323.1
CIPC	huMAP3_01886.1 huMAP3_12955.1 huMAP3_15323.1
DHTKD1	huMAP3_05189.1 huMAP3_11321.1 huMAP3_13081.1 huMAP3_13625.1 huMAP3_13937.1 huMAP3_14406.1 huMAP3_15323.1
NPAS2	huMAP3_01886.1 huMAP3_12955.1 huMAP3_15323.1
CLOCK	huMAP3_01886.1 huMAP3_12955.1 huMAP3_15323.1
TDRD9	huMAP3_12955.1 huMAP3_15323.1
BMAL1	huMAP3_01886.1 huMAP3_12955.1 huMAP3_15323.1
MSRA	huMAP3_02429.1 huMAP3_03943.1 huMAP3_06479.1 huMAP3_10617.1 huMAP3_10629.1 huMAP3_11939.1 huMAP3_13828.1 huMAP3_14980.1 huMAP3_15323.1
PDE6A	huMAP3_12955.1 huMAP3_15323.1
KHDC4	huMAP3_12955.1 huMAP3_15323.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_15323.1

Complex Portal: CPX-19255