hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_15329.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KRT76 | Keratin, type II cytoskeletal 2 oral (Cytokeratin-2P) (CK-2P) (K2P) (Keratin-76) (K76) (Type-II keratin Kb9) | 5 | UniProt NCBI |
| KRT78 | Keratin, type II cytoskeletal 78 (Cytokeratin-78) (CK-78) (Keratin-5b) (Keratin-78) (K78) (Type-II keratin Kb40) | 5 | UniProt NCBI |
| KRT77 | Keratin, type II cytoskeletal 1b (Cytokeratin-1B) (CK-1B) (Keratin-77) (K77) (Type-II keratin Kb39) | 5 | UniProt NCBI |
| KRT6B | Keratin, type II cytoskeletal 6B (Cytokeratin-6B) (CK-6B) (Keratin-6B) (K6B) (Type-II keratin Kb10) | 5 | UniProt NCBI |
| KRT3 | Keratin, type II cytoskeletal 3 (65 kDa cytokeratin) (Cytokeratin-3) (CK-3) (Keratin-3) (K3) (Type-II keratin Kb3) | 5 | UniProt NCBI |
| KRT14 | Keratin, type I cytoskeletal 14 (Cytokeratin-14) (CK-14) (Keratin-14) (K14) | 5 | UniProt NCBI |
| KRT16 | Keratin, type I cytoskeletal 16 (Cytokeratin-16) (CK-16) (Keratin-16) (K16) | 5 | UniProt NCBI |
| KRT6C | Keratin, type II cytoskeletal 6C (Cytokeratin-6C) (CK-6C) (Cytokeratin-6E) (CK-6E) (Keratin K6h) (Keratin-6C) (K6C) (Type-II keratin Kb12) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0045095 | 1.16553895608e-15 | 1.0 | KRT14 KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | keratin filament |
| REAC:R-HSA-6809371 | 5.97250916558e-15 | 1.0 | KRT14 KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | Formation of the cornified envelope |
| REAC:R-HSA-6805567 | 7.40957509383e-15 | 1.0 | KRT14 KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | Keratinization |
| GO:0045109 | 2.23615080628e-14 | 1.0 | KRT14 KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | intermediate filament organization |
| GO:0045104 | 2.3704943205e-13 | 1.0 | KRT14 KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | intermediate filament cytoskeleton organization |
| GO:0045103 | 2.7312217171e-13 | 1.0 | KRT14 KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | intermediate filament-based process |
| GO:0005882 | 9.8032611783e-13 | 1.0 | KRT14 KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | intermediate filament |
| GO:0031424 | 1.40340440006e-12 | 0.857142857143 | KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | keratinization |
| GO:0045111 | 1.67860687347e-11 | 1.0 | KRT14 KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | intermediate filament cytoskeleton |
| GO:0008544 | 9.85255629495e-10 | 1.0 | KRT14 KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | epidermis development |
| GO:0030280 | 4.96990184286e-09 | 0.714285714286 | KRT6C KRT77 KRT76 KRT6B KRT78 | structural constituent of skin epidermis |
| GO:0030216 | 7.74476915066e-09 | 0.857142857143 | KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | keratinocyte differentiation |
| GO:0009913 | 4.92365149219e-08 | 0.857142857143 | KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | epidermal cell differentiation |
| GO:0043588 | 1.39386944178e-07 | 0.857142857143 | KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | skin development |
| GO:0030855 | 1.69950901305e-07 | 1.0 | KRT14 KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | epithelial cell differentiation |
| REAC:R-HSA-1266738 | 4.40434374571e-07 | 1.0 | KRT14 KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | Developmental Biology |
| GO:0099513 | 7.57915114365e-07 | 1.0 | KRT14 KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | polymeric cytoskeletal fiber |
| GO:0005198 | 2.98560437487e-06 | 1.0 | KRT14 KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | structural molecule activity |
| GO:0060429 | 3.81328489343e-06 | 1.0 | KRT14 KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | epithelium development |
| HP:0007446 | 4.78381267099e-06 | 0.428571428571 | KRT6B KRT16 KRT14 | Palmoplantar blistering |
| GO:0099512 | 5.63055144053e-06 | 1.0 | KRT14 KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | supramolecular fiber |
| GO:0099081 | 6.14784766172e-06 | 1.0 | KRT14 KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | supramolecular polymer |
| GO:0097435 | 1.0073051387e-05 | 1.0 | KRT14 KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | supramolecular fiber organization |
| HP:0000982 | 4.49117687237e-05 | 0.571428571429 | KRT6B KRT16 KRT6C KRT14 | Palmoplantar keratoderma |
| HP:0000972 | 7.62499054718e-05 | 0.571428571429 | KRT6B KRT16 KRT6C KRT14 | Palmoplantar hyperkeratosis |
| HP:0010765 | 7.91979887457e-05 | 0.571428571429 | KRT6B KRT16 KRT6C KRT14 | Palmar hyperkeratosis |
| HP:0007556 | 8.22304856864e-05 | 0.571428571429 | KRT6B KRT16 KRT6C KRT14 | Plantar hyperkeratosis |
| HP:0033800 | 0.000100569052035 | 0.428571428571 | KRT6B KRT16 KRT14 | Blistering by anatomical location |
| GO:0099080 | 0.000131562698178 | 1.0 | KRT14 KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | supramolecular complex |
| HP:0002745 | 0.000147554136555 | 0.428571428571 | KRT6B KRT6C KRT16 | Oral leukoplakia |
| HP:0025125 | 0.000147554136555 | 0.428571428571 | KRT6B KRT6C KRT16 | White lesion of the oral mucosa |
| HP:0001805 | 0.000165964290174 | 0.428571428571 | KRT6B KRT16 KRT14 | Onychogryposis |
| HP:0100872 | 0.000227330971162 | 0.571428571429 | KRT6B KRT16 KRT6C KRT14 | Abnormality of the plantar skin of foot |
| GO:0009888 | 0.000260348048476 | 1.0 | KRT14 KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | tissue development |
| HP:0012514 | 0.000339043524082 | 0.428571428571 | KRT6B KRT16 KRT14 | Lower limb pain |
| GO:0007010 | 0.000680739891253 | 1.0 | KRT14 KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | cytoskeleton organization |
| HP:0000962 | 0.000939038078382 | 0.571428571429 | KRT6B KRT16 KRT6C KRT14 | Hyperkeratosis |
| HP:0025248 | 0.000999430167489 | 0.285714285714 | KRT6B KRT16 | Eruptive vellus hair cyst |
| HP:0012035 | 0.000999430167489 | 0.285714285714 | KRT6B KRT16 | Steatocystoma multiplex |
| HP:0009763 | 0.00104065814502 | 0.428571428571 | KRT6B KRT16 KRT14 | Limb pain |
| HPA:0461451 | 0.00105401230366 | 0.571428571429 | KRT6B KRT78 KRT6C KRT14 | skin 1; hair follicles[>=Low] |
| HP:0007490 | 0.00166533696614 | 0.285714285714 | KRT6B KRT16 | Linear arrays of macular hyperkeratoses in flexural areas |
| HP:0030268 | 0.00166533696614 | 0.285714285714 | KRT6B KRT16 | Hyperplastic callus formation |
| HPA:0461453 | 0.00178462677866 | 0.428571428571 | KRT6B KRT6C KRT14 | skin 1; hair follicles[High] |
| HP:0008401 | 0.00249743559672 | 0.285714285714 | KRT6B KRT16 | Onychogryposis of toenails |
| HP:0040036 | 0.0046597529865 | 0.285714285714 | KRT6B KRT16 | Onychogryposis of fingernail |
| HP:0011830 | 0.00511462604842 | 0.571428571429 | KRT6B KRT16 KRT6C KRT14 | Abnormal oral mucosa morphology |
| HP:0011368 | 0.00627308861937 | 0.571428571429 | KRT6B KRT16 KRT6C KRT14 | Epidermal thickening |
| GO:0005856 | 0.00665123557963 | 1.0 | KRT14 KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | cytoskeleton |
| HP:0030318 | 0.00748547207011 | 0.285714285714 | KRT6B KRT16 | Angular cheilitis |
| HP:0008066 | 0.00799268155862 | 0.428571428571 | KRT6B KRT16 KRT14 | Abnormal blistering of the skin |
| HP:0001609 | 0.0082460673058 | 0.428571428571 | KRT6B KRT16 KRT14 | Hoarse voice |
| HP:0040211 | 0.00836238378055 | 0.571428571429 | KRT6B KRT16 KRT6C KRT14 | Abnormal skin morphology of the palm |
| HPA:0461403 | 0.00887217509359 | 0.285714285714 | KRT6B KRT6C | skin 1; cells in corneal layer[High] |
| HP:0007410 | 0.00914682299331 | 0.285714285714 | KRT6B KRT16 | Palmoplantar hyperhidrosis |
| HP:0001072 | 0.0101272255372 | 0.571428571429 | KRT6B KRT16 KRT6C KRT14 | Thickened skin |
| HPA:0471403 | 0.0107616123041 | 0.285714285714 | KRT6B KRT6C | skin 2; cells in corneal layer[High] |
| HP:0006089 | 0.0109736833289 | 0.285714285714 | KRT6B KRT16 | Palmar hyperhidrosis |
| KEGG:05150 | 0.0129401293802 | 0.285714285714 | KRT14 KRT16 | Staphylococcus aureus infection |
| HP:0008404 | 0.0172483920487 | 0.428571428571 | KRT6B KRT16 KRT14 | Nail dystrophy |
| HP:0100798 | 0.0174461853129 | 0.285714285714 | KRT6B KRT16 | Fingernail dysplasia |
| HP:0030766 | 0.0174461853129 | 0.285714285714 | KRT6B KRT16 | Ear pain |
| HP:0200040 | 0.0174461853129 | 0.285714285714 | KRT6B KRT16 | Epidermoid cyst |
| HP:0100871 | 0.0189709720562 | 0.571428571429 | KRT6B KRT16 KRT6C KRT14 | Abnormal palm morphology |
| HP:0001818 | 0.0199339480346 | 0.285714285714 | KRT6B KRT16 | Paronychia |
| HP:0002164 | 0.0217618596498 | 0.428571428571 | KRT6B KRT16 KRT14 | Nail dysplasia |
| HPA:0461452 | 0.0237559447368 | 0.428571428571 | KRT6B KRT6C KRT14 | skin 1; hair follicles[>=Medium] |
| GO:0070062 | 0.0239791568402 | 1.0 | KRT14 KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | extracellular exosome |
| HP:0000975 | 0.024284645806 | 0.428571428571 | KRT6B KRT16 KRT14 | Hyperhidrosis |
| HPA:0471393 | 0.0247756247188 | 0.428571428571 | KRT6B KRT6C KRT14 | skin 2; cells in basal layer[High] |
| GO:1903561 | 0.0255843975786 | 1.0 | KRT14 KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | extracellular vesicle |
| GO:0065010 | 0.0256816238452 | 1.0 | KRT14 KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | extracellular membrane-bounded organelle |
| GO:0043230 | 0.0256816238452 | 1.0 | KRT14 KRT6C KRT76 KRT77 KRT78 KRT6B KRT16 | extracellular organelle |
| HP:0011356 | 0.0259673377146 | 0.571428571429 | KRT6B KRT16 KRT6C KRT14 | Regional abnormality of skin |
| HPA:0461402 | 0.0290268891277 | 0.285714285714 | KRT6B KRT6C | skin 1; cells in corneal layer[>=Medium] |
| HP:0025245 | 0.0348446257606 | 0.285714285714 | KRT6B KRT16 | Cutaneous cyst |
| HP:0100803 | 0.0383203414044 | 0.285714285714 | KRT6B KRT16 | Abnormality of the periungual region |
| HP:0001231 | 0.0405415169637 | 0.428571428571 | KRT6B KRT16 KRT14 | Abnormal fingernail morphology |
| KEGG:04915 | 0.0420880817615 | 0.285714285714 | KRT14 KRT16 | Estrogen signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| KRT3 | KRT16 | 0.936 | 0.312 | youn_WMM gupta_WMM WMM_only boldt_WMM |
| KRT76 | KRT3 | 0.929 | gupta_WMM WMM_only boldt_WMM | |
| KRT16 | KRT6C | 0.921 | youn_WMM gupta_WMM WMM_only boldt_WMM | |
| KRT78 | KRT16 | 0.918 | 0.366 | youn_WMM WMM_only boldt_WMM |
| KRT3 | KRT6C | 0.906 | youn_WMM gupta_WMM WMM_only boldt_WMM | |
| KRT77 | KRT16 | 0.902 | 0.446 | youn_WMM fraction boldt_WMM |
| KRT78 | KRT3 | 0.892 | 0.294 | youn_WMM WMM_only boldt_WMM |
| KRT6B | KRT77 | 0.89 | 0.222 | youn_WMM fraction boldt_WMM |
| KRT77 | KRT3 | 0.881 | 0.158 | youn_WMM WMM_only boldt_WMM |
| KRT78 | KRT6C | 0.868 | youn_WMM WMM_only boldt_WMM | |
| KRT77 | KRT6C | 0.855 | youn_WMM WMM_only boldt_WMM | |
| KRT78 | KRT77 | 0.855 | 0.376 | youn_WMM WMM_only boldt_WMM |
| KRT78 | KRT14 | 0.807 | 0.474 | youn_WMM WMM_only boldt_WMM |
| KRT6B | KRT3 | 0.783 | 0.444 | gupta_WMM WMM_only boldt_WMM |
| KRT6C | KRT14 | 0.765 | youn_WMM gupta_WMM WMM_only boldt_WMM | |
| KRT76 | KRT78 | 0.761 | WMM_only boldt_WMM | |
| KRT6B | KRT6C | 0.733 | gupta_WMM WMM_only boldt_WMM | |
| KRT6B | KRT78 | 0.647 | 0.368 | WMM_only boldt_WMM |
| KRT77 | KRT14 | 0.639 | 0.476 | youn_WMM WMM_only boldt_WMM |
| KRT6B | KRT16 | 0.472 | 0.332 | youn_WMM gupta_WMM WMM_only boldt_WMM |
| KRT6B | KRT14 | 0.471 | 0.486 | youn_WMM gupta_WMM WMM_only boldt_WMM |
| KRT16 | KRT14 | 0.336 | 0.524 | youn_WMM gupta_WMM WMM_only boldt_WMM |
| KRT76 | KRT16 | 0.169 | gupta_WMM WMM_only boldt_WMM | |
| KRT76 | KRT6C | 0.077 | gupta_WMM WMM_only boldt_WMM | |
| KRT3 | KRT14 | 0.068 | 0.55 | youn_WMM gupta_WMM WMM_only boldt_WMM |
| KRT6B | KRT76 | 0.068 | gupta_WMM WMM_only boldt_WMM | |
| KRT76 | KRT77 | 0.03 | fraction boldt_WMM | |
| KRT76 | KRT14 | 0.029 | gupta_WMM WMM_only boldt_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| KRT76 | huMAP3_13431.1 huMAP3_14922.1 huMAP3_15329.1 |
| KRT78 | huMAP3_13431.1 huMAP3_14922.1 huMAP3_15329.1 |
| KRT77 | huMAP3_13431.1 huMAP3_14922.1 huMAP3_15329.1 |
| KRT6B | huMAP3_01811.1 huMAP3_11964.1 huMAP3_15329.1 |
| KRT3 | huMAP3_13431.1 huMAP3_14922.1 huMAP3_15329.1 |
| KRT14 | huMAP3_14922.1 huMAP3_15329.1 |
| KRT16 | huMAP3_13431.1 huMAP3_14922.1 huMAP3_15329.1 |
| KRT6C | huMAP3_13431.1 huMAP3_14922.1 huMAP3_15329.1 |