hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14031.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PPP6R2 | Serine/threonine-protein phosphatase 6 regulatory subunit 2 (SAPS domain family member 2) | 5 | UniProt NCBI |
| SPART | Spartin (Spastic paraplegia 20 protein) (Trans-activated by hepatitis C virus core protein 1) | 5 | UniProt NCBI |
| ANKRD28 | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK) | 5 | UniProt NCBI |
| PPP6R3 | Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) | 5 | UniProt NCBI |
| ANKRD52 | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) (Ankyrin repeat domain-containing protein 52) | 3 | UniProt NCBI |
| PPP6C | Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) [Cleaved into: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed] | 5 | UniProt NCBI |
| ANKRD44 | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) | 4 | UniProt NCBI |
| PPP6R1 | Serine/threonine-protein phosphatase 6 regulatory subunit 1 (SAPS domain family member 1) | 5 | UniProt NCBI |
| MRNIP | MRN complex-interacting protein (MRN-interacting protein) | 5 | UniProt NCBI |
| CTCFL | Transcriptional repressor CTCFL (Brother of the regulator of imprinted sites) (CCCTC-binding factor) (CTCF paralog) (CTCF-like protein) (Cancer/testis antigen 27) (CT27) (Zinc finger protein CTCF-T) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5196 | 3.98250603803e-09 | 0.4 | PPP6R1 PPP6R2 PPP6C ANKRD28 | TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1) |
| REAC:R-HSA-204005 | 1.36716025886e-05 | 0.4 | PPP6R1 ANKRD28 PPP6R3 PPP6C | COPII-mediated vesicle transport |
| REAC:R-HSA-171319 | 9.79763261181e-05 | 0.3 | ANKRD28 PPP6R3 PPP6C | Telomere Extension By Telomerase |
| REAC:R-HSA-199977 | 0.000425872013598 | 0.4 | PPP6R1 ANKRD28 PPP6R3 PPP6C | ER to Golgi Anterograde Transport |
| REAC:R-HSA-948021 | 0.000889205200481 | 0.4 | PPP6R1 ANKRD28 PPP6R3 PPP6C | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-180786 | 0.00114054706802 | 0.3 | ANKRD28 PPP6R3 PPP6C | Extension of Telomeres |
| REAC:R-HSA-446203 | 0.00636866609671 | 0.4 | PPP6R1 ANKRD28 PPP6R3 PPP6C | Asparagine N-linked glycosylation |
| REAC:R-HSA-157579 | 0.00870109711608 | 0.3 | ANKRD28 PPP6R3 PPP6C | Telomere Maintenance |
| REAC:R-HSA-73886 | 0.0177651546753 | 0.3 | ANKRD28 PPP6R3 PPP6C | Chromosome Maintenance |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ANKRD28 | PPP6C | 1.0 | 0.156 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| ANKRD52 | PPP6C | 1.0 | 0.054 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| PPP6C | PPP6R1 | 1.0 | 0.26 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| PPP6C | ANKRD44 | 1.0 | 0.094 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| ANKRD28 | ANKRD44 | 1.0 | 0.256 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| PPP6R2 | PPP6C | 1.0 | 0.082 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| PPP6R3 | PPP6C | 1.0 | 0.444 | hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| PPP6R2 | ANKRD44 | 1.0 | 0.126 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| ANKRD44 | PPP6R1 | 1.0 | 0.018 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| PPP6R2 | ANKRD28 | 1.0 | 0.092 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM boldt_WMM |
| ANKRD52 | PPP6R2 | 0.999 | 0.088 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| ANKRD52 | ANKRD28 | 0.999 | 0.046 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| PPP6R2 | PPP6R3 | 0.999 | 0.084 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM boldt_WMM |
| PPP6R3 | ANKRD44 | 0.999 | 0.02 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| ANKRD52 | PPP6R1 | 0.999 | 0.046 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| ANKRD28 | PPP6R3 | 0.999 | 0.176 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM boldt_WMM |
| PPP6R2 | PPP6R1 | 0.998 | 0.042 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| ANKRD52 | ANKRD44 | 0.998 | 0.066 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| PPP6R3 | PPP6R1 | 0.997 | 0.09 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only |
| ANKRD28 | PPP6R1 | 0.997 | 0.112 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM boldt_WMM |
| ANKRD52 | PPP6R3 | 0.996 | 0.118 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
| ANKRD44 | SPART | 0.987 | 0.026 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ANKRD44 | MRNIP | 0.983 | 0.0812 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| PPP6R1 | SPART | 0.945 | 0.028 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| ANKRD44 | CTCFL | 0.837 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PPP6C | SPART | 0.755 | 0.058 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| ANKRD28 | CTCFL | 0.209 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ANKRD28 | SPART | 0.199 | 0.036 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| ANKRD52 | SPART | 0.18 | 0.052 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| PPP6R2 | MRNIP | 0.175 | 0.074 | bioplex3_WMM WMM_only |
| ANKRD28 | MRNIP | 0.102 | 0.208 | bioplex3_WMM WMM_only |
| PPP6R1 | MRNIP | 0.102 | 0.158 | bioplex3_WMM WMM_only |
| PPP6R2 | CTCFL | 0.086 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PPP6R3 | CTCFL | 0.078 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PPP6R3 | MRNIP | 0.068 | 0.14 | bioplex3_WMM WMM_only |
| PPP6R3 | SPART | 0.054 | 0.048 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| PPP6R1 | CTCFL | 0.042 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PPP6C | CTCFL | 0.031 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ANKRD52 | MRNIP | 0.027 | 0.08 | bioplex3_WMM WMM_only |
| ANKRD52 | CTCFL | 0.02 | bioplex3_HEK293 WMM_only | |
| PPP6C | MRNIP | 0.018 | 0.108 | bioplex3_WMM gupta_WMM WMM_only |
| MRNIP | SPART | 0.008 | 0.106 | gupta_WMM WMM_only |
| PPP6R2 | SPART | 0.002 | 0.042 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes