hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_13927.1
Complex Portal: CPX-19191
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GIT2 | ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) | 5 | UniProt NCBI |
| ARHGEF7 | Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85) | 5 | UniProt NCBI |
| ARHGEF6 | Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6) | 5 | UniProt NCBI |
| GIT1 | ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) | 5 | UniProt NCBI |
| NT5DC3 | 5'-nucleotidase domain-containing protein 3 (EC 3.1.3.-) (GRP94-neighboring nucleotidase) | 4 | UniProt NCBI |
| FBXO28 | F-box only protein 28 | 5 | UniProt NCBI |
| TAX1BP3 | Tax1-binding protein 3 (Glutaminase-interacting protein 3) (Tax interaction protein 1) (TIP-1) (Tax-interacting protein 1) | 5 | UniProt NCBI |
| PAK1 | Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) | 5 | UniProt NCBI |
| NANP | N-acylneuraminate-9-phosphatase (EC 3.1.3.29) (Haloacid dehalogenase-like hydrolase domain-containing protein 4) (Neu5Ac-9-Pase) | 5 | UniProt NCBI |
| TMCC3 | Transmembrane and coiled-coil domain protein 3 | 4 | UniProt NCBI |
| PAK2 | Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9013420 | 2.03924458832e-11 | 0.545454545455 | GIT1 ARHGEF6 PAK2 PAK1 GIT2 ARHGEF7 | RHOU GTPase cycle |
| REAC:R-HSA-9013424 | 6.92576147827e-09 | 0.454545454545 | GIT1 PAK2 GIT2 PAK1 ARHGEF7 | RHOV GTPase cycle |
| CORUM:6928 | 2.10621603952e-08 | 0.272727272727 | PAK1 GIT2 ARHGEF7 | ARHGEF7-GIT2-PAK1 complex |
| REAC:R-HSA-9013148 | 4.20843010097e-08 | 0.545454545455 | GIT1 ARHGEF6 PAK2 PAK1 GIT2 ARHGEF7 | CDC42 GTPase cycle |
| REAC:R-HSA-9013406 | 6.08456596542e-08 | 0.454545454545 | GIT1 PAK2 GIT2 PAK1 ARHGEF7 | RHOQ GTPase cycle |
| REAC:R-HSA-9013409 | 6.08456596542e-08 | 0.454545454545 | GIT1 PAK2 GIT2 PAK1 ARHGEF7 | RHOJ GTPase cycle |
| REAC:R-HSA-3928664 | 8.15068333788e-08 | 0.363636363636 | GIT1 PAK2 ARHGEF7 PAK1 | Ephrin signaling |
| CORUM:6779 | 8.42140472852e-08 | 0.272727272727 | GIT1 ARHGEF7 PAK1 | SCRIB-GIT1-ARHGEF7-PAK1 complex |
| CORUM:6778 | 8.42140472852e-08 | 0.272727272727 | GIT1 ARHGEF7 PAK1 | SCRIB-GIT1-ARHGEF7-PAK1 complex |
| CORUM:6341 | 8.42140472852e-08 | 0.272727272727 | GIT1 ARHGEF7 PAK1 | GIT1-ARHGEF7-PAK1-PXN complex |
| REAC:R-HSA-9013149 | 1.66144236137e-07 | 0.545454545455 | GIT1 ARHGEF6 PAK2 PAK1 GIT2 ARHGEF7 | RAC1 GTPase cycle |
| WP:WP51 | 2.2027047295e-06 | 0.454545454545 | GIT1 PAK2 ARHGEF7 PAK1 ARHGEF6 | Regulation of actin cytoskeleton |
| KEGG:04810 | 8.86336968651e-06 | 0.454545454545 | GIT1 PAK2 ARHGEF7 PAK1 ARHGEF6 | Regulation of actin cytoskeleton |
| REAC:R-HSA-194315 | 1.96700782079e-05 | 0.636363636364 | GIT1 ARHGEF6 GIT2 ARHGEF7 PAK1 TAX1BP3 PAK2 | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 2.28785816855e-05 | 0.636363636364 | GIT1 ARHGEF6 GIT2 ARHGEF7 PAK1 TAX1BP3 PAK2 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| WP:WP185 | 3.39193311975e-05 | 0.363636363636 | PAK1 PAK2 GIT2 ARHGEF7 | Integrin mediated cell adhesion |
| REAC:R-HSA-9012999 | 3.94559110311e-05 | 0.545454545455 | GIT1 ARHGEF6 PAK2 PAK1 GIT2 ARHGEF7 | RHO GTPase cycle |
| REAC:R-HSA-2682334 | 7.6369373734e-05 | 0.363636363636 | GIT1 PAK2 ARHGEF7 PAK1 | EPH-Ephrin signaling |
| REAC:R-HSA-9013404 | 8.02053265718e-05 | 0.363636363636 | GIT1 PAK2 GIT2 PAK1 | RAC2 GTPase cycle |
| REAC:R-HSA-9013423 | 9.25784528685e-05 | 0.363636363636 | GIT1 PAK2 GIT2 PAK1 | RAC3 GTPase cycle |
| CORUM:930 | 0.000102551658964 | 0.181818181818 | GIT1 ARHGEF7 | SCRIB-GIT1-ARHGEF7 complex |
| WP:WP4263 | 0.00273581026429 | 0.272727272727 | PAK1 ARHGEF6 PAK2 | Pancreatic adenocarcinoma pathway |
| REAC:R-HSA-389359 | 0.005984434688 | 0.181818181818 | PAK1 PAK2 | CD28 dependent Vav1 pathway |
| REAC:R-HSA-428540 | 0.0103602481019 | 0.181818181818 | PAK1 PAK2 | Activation of RAC1 |
| GO:0010968 | 0.0107228250299 | 0.272727272727 | GIT1 ARHGEF7 PAK1 | regulation of microtubule nucleation |
| REAC:R-HSA-399954 | 0.0139350375231 | 0.181818181818 | PAK1 PAK2 | Sema3A PAK dependent Axon repulsion |
| REAC:R-HSA-8964616 | 0.020280338984 | 0.181818181818 | PAK1 ARHGEF6 | G beta:gamma signalling through CDC42 |
| WP:WP4874 | 0.0231182298902 | 0.181818181818 | GIT1 ARHGEF7 | CAMKK2 pathway |
| REAC:R-HSA-5627123 | 0.0251640576042 | 0.181818181818 | PAK1 PAK2 | RHO GTPases activate PAKs |
| REAC:R-HSA-5621575 | 0.0251640576042 | 0.181818181818 | PAK1 PAK2 | CD209 (DC-SIGN) signaling |
| REAC:R-HSA-2871796 | 0.0278014860056 | 0.181818181818 | PAK1 PAK2 | FCERI mediated MAPK activation |
| WP:WP4564 | 0.0297656085673 | 0.181818181818 | PAK1 PAK2 | Neural crest cell migration during development |
| WP:WP4565 | 0.0333991755733 | 0.181818181818 | PAK1 PAK2 | Neural crest cell migration in cancer |
| GO:0043015 | 0.0361493524666 | 0.272727272727 | GIT1 ARHGEF7 PAK1 | gamma-tubulin binding |
| REAC:R-HSA-5218920 | 0.0364941063676 | 0.181818181818 | PAK1 PAK2 | VEGFR2 mediated vascular permeability |
| REAC:R-HSA-202433 | 0.0364941063676 | 0.181818181818 | PAK1 PAK2 | Generation of second messenger molecules |
| WP:WP314 | 0.0372386402869 | 0.181818181818 | PAK1 PAK2 | Fas ligand pathway and stress induction of heat shock proteins |
| WP:WP4534 | 0.0412834882198 | 0.181818181818 | PAK1 PAK2 | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms |
| REAC:R-HSA-397795 | 0.0463538386504 | 0.181818181818 | PAK1 ARHGEF6 | G-protein beta:gamma signalling |
| REAC:R-HSA-162582 | 0.0495465193669 | 0.636363636364 | GIT1 ARHGEF6 GIT2 ARHGEF7 PAK1 TAX1BP3 PAK2 | Signal Transduction |
| KEGG:05120 | 0.0499975159732 | 0.181818181818 | GIT1 PAK1 | Epithelial cell signaling in Helicobacter pylori infection |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ARHGEF6 | GIT1 | 1.0 | 0.218 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| ARHGEF7 | ARHGEF6 | 1.0 |
mutually_exclusive (Q9Y2X7)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| GIT2 | ARHGEF6 | 1.0 | 0.372 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| ARHGEF6 | PAK1 | 1.0 | 0.108 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GIT2 | PAK2 | 1.0 | 0.08 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| ARHGEF7 | PAK2 | 1.0 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM | ||
| ARHGEF6 | PAK2 | 0.999 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GIT2 | ARHGEF7 | 0.999 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM | ||
| ARHGEF7 | GIT1 | 0.999 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | |
| ARHGEF7 | PAK1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| GIT1 | PAK2 | 0.998 | 0.188 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM | |
| GIT2 | GIT1 | 0.997 | 0.216 |
mutually_exclusive (Q15052)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM |
| TAX1BP3 | ARHGEF7 | 0.997 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NT5DC3 | ARHGEF6 | 0.995 | 0.092 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FBXO28 | TMCC3 | 0.994 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GIT2 | PAK1 | 0.994 | 0.128 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| PAK1 | GIT1 | 0.993 | 0.07 | bioplex_WMM bioplex3_WMM WMM_only | |
| FBXO28 | ARHGEF7 | 0.99 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| FBXO28 | ARHGEF6 | 0.984 | 0.038 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| FBXO28 | PAK1 | 0.983 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PAK1 | PAK2 | 0.983 | 0.42 | bioplex_WMM bioplex3_WMM fraction | |
| FBXO28 | GIT2 | 0.982 | 0.08 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TAX1BP3 | ARHGEF6 | 0.978 | 0.044 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FBXO28 | GIT1 | 0.972 | 0.056 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TAX1BP3 | PAK1 | 0.964 | 0.166 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TAX1BP3 | GIT1 | 0.964 | 0.026 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FBXO28 | PAK2 | 0.959 | 0.088 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| TAX1BP3 | GIT2 | 0.936 | 0.03 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TAX1BP3 | PAK2 | 0.88 | 0.052 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PAK2 | NANP | 0.879 | 0.042 | hein_WMM youn_WMM gupta_WMM WMM_only | |
| TMCC3 | GIT1 | 0.607 | 0.198231884058 | bioplex_WMM bioplex3_WMM WMM_only | |
| TMCC3 | ARHGEF7 | 0.581 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TMCC3 | PAK1 | 0.575 | 0.146 | bioplex_WMM bioplex3_WMM WMM_only | |
| NT5DC3 | PAK1 | 0.523 | 0.076 | bioplex3_WMM WMM_only | |
| NT5DC3 | GIT1 | 0.489 | 0.046 | bioplex3_WMM WMM_only | |
| NT5DC3 | GIT2 | 0.476 | 0.112 | bioplex3_WMM WMM_only | |
| TMCC3 | GIT2 | 0.473 | 0.16 | bioplex_WMM bioplex3_WMM WMM_only | |
| NT5DC3 | ARHGEF7 | 0.454 | bioplex3_WMM WMM_only | ||
| TMCC3 | ARHGEF6 | 0.439 | 0.174 | bioplex_WMM bioplex3_WMM WMM_only | |
| TMCC3 | PAK2 | 0.219 | 0.148 | bioplex_WMM bioplex3_WMM WMM_only | |
| NT5DC3 | PAK2 | 0.195 | 0.03 | bioplex3_WMM WMM_only | |
| FBXO28 | TAX1BP3 | 0.099 | 0.07 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| NT5DC3 | FBXO28 | 0.089 | 0.012 | bioplex3_WMM WMM_only | |
| ARHGEF7 | NANP | 0.006 | youn_WMM gupta_WMM WMM_only | ||
| GIT2 | NANP | 0.006 | 0.046 | youn_WMM WMM_only | |
| GIT1 | NANP | 0.006 | 0.026 | youn_WMM WMM_only |
Related Complexes