hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_13927.1

Complex Portal: CPX-19191

Confidence: Medium

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Genename	Protein Name	Uniprot Annotation Score	Links
ARHGEF6	Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6)	5	UniProt NCBI
ARHGEF7	Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85)	5	UniProt NCBI
FBXO28	F-box only protein 28	5	UniProt NCBI
GIT1	ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1)	5	UniProt NCBI
GIT2	ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2)	5	UniProt NCBI
NANP	N-acylneuraminate-9-phosphatase (EC 3.1.3.29) (Haloacid dehalogenase-like hydrolase domain-containing protein 4) (Neu5Ac-9-Pase)	5	UniProt NCBI
NT5DC3	5'-nucleotidase domain-containing protein 3 (EC 3.1.3.-) (GRP94-neighboring nucleotidase)	4	UniProt NCBI
PAK1	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK)	5	UniProt NCBI
PAK2	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)]	5	UniProt NCBI
TAX1BP3	Tax1-binding protein 3 (Glutaminase-interacting protein 3) (Tax interaction protein 1) (TIP-1) (Tax-interacting protein 1)	5	UniProt NCBI

Showing 1 to 10 of 11 entries

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Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-9013420	2.03924458832e-11	0.545454545455	PAK2 ARHGEF7 PAK1 GIT1 GIT2 ARHGEF6	RHOU GTPase cycle
REAC:R-HSA-9013424	6.92576147827e-09	0.454545454545	PAK2 GIT2 GIT1 PAK1 ARHGEF7	RHOV GTPase cycle
CORUM:6928	2.10621603952e-08	0.272727272727	GIT2 PAK1 ARHGEF7	ARHGEF7-GIT2-PAK1 complex
REAC:R-HSA-9013148	4.20843010097e-08	0.545454545455	PAK2 ARHGEF7 PAK1 GIT1 GIT2 ARHGEF6	CDC42 GTPase cycle
REAC:R-HSA-9013406	6.08456596542e-08	0.454545454545	PAK2 GIT2 GIT1 PAK1 ARHGEF7	RHOQ GTPase cycle
REAC:R-HSA-9013409	6.08456596542e-08	0.454545454545	PAK2 GIT2 GIT1 PAK1 ARHGEF7	RHOJ GTPase cycle
REAC:R-HSA-3928664	8.15068333788e-08	0.363636363636	PAK2 ARHGEF7 PAK1 GIT1	Ephrin signaling
CORUM:6779	8.42140472852e-08	0.272727272727	ARHGEF7 PAK1 GIT1	SCRIB-GIT1-ARHGEF7-PAK1 complex
CORUM:6778	8.42140472852e-08	0.272727272727	ARHGEF7 PAK1 GIT1	SCRIB-GIT1-ARHGEF7-PAK1 complex
CORUM:6341	8.42140472852e-08	0.272727272727	ARHGEF7 PAK1 GIT1	GIT1-ARHGEF7-PAK1-PXN complex

Showing 1 to 10 of 41 entries

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Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
ARHGEF6	GIT1	1.0	0.218	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM
ARHGEF7	ARHGEF6	1.0		mutually_exclusive (Q9Y2X7)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM
GIT2	ARHGEF6	1.0	0.372	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM
ARHGEF6	PAK1	1.0	0.108		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
GIT2	PAK2	1.0	0.08		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein ()
ARHGEF7	PAK2	1.0			hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM
ARHGEF6	PAK2	0.999	0.09		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
GIT2	ARHGEF7	0.999			hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM
ARHGEF7	GIT1	0.999		structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM
ARHGEF7	PAK1	0.999			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116

Showing 1 to 10 of 46 entries

Related Complexes

Genename	Complexes
GIT2	huMAP3_05415.1 huMAP3_13927.1 huMAP3_14886.1
ARHGEF7	huMAP3_05415.1 huMAP3_07520.1 huMAP3_13927.1 huMAP3_14886.1
ARHGEF6	huMAP3_05415.1 huMAP3_13927.1 huMAP3_14886.1
GIT1	huMAP3_05415.1 huMAP3_13927.1 huMAP3_14886.1
NT5DC3	huMAP3_00646.1 huMAP3_05415.1 huMAP3_08359.1 huMAP3_13927.1 huMAP3_14553.1
FBXO28	huMAP3_02413.1 huMAP3_05415.1 huMAP3_07151.1 huMAP3_13927.1
TAX1BP3	huMAP3_04230.1 huMAP3_12107.1 huMAP3_13927.1 huMAP3_14886.1
PAK1	huMAP3_05415.1 huMAP3_13927.1 huMAP3_14886.1
NANP	huMAP3_12610.1 huMAP3_13927.1
TMCC3	huMAP3_02413.1 huMAP3_03087.1 huMAP3_04656.1 huMAP3_05897.1 huMAP3_07151.1 huMAP3_11059.1 huMAP3_11759.1 huMAP3_13231.1 huMAP3_13597.1 huMAP3_13927.1 huMAP3_14661.1
PAK2	huMAP3_05415.1 huMAP3_12238.1 huMAP3_12610.1 huMAP3_13927.1