hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08393.1

Complex Portal: CPX-16227

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
ATP5PD	ATP synthase subunit d, mitochondrial (ATPase subunit d) (ATP synthase peripheral stalk subunit d)	5	UniProt NCBI
POMK	Protein O-mannose kinase (POMK) (EC 2.7.1.183) (Protein kinase-like protein SgK196) (Sugen kinase 196)	5	UniProt NCBI
CERS2	Ceramide synthase 2 (CerS2) (LAG1 longevity assurance homolog 2) (SP260) (Sphingosine N-acyltransferase CERS2) (EC 2.3.1.24) (Tumor metastasis-suppressor gene 1 protein) (Very-long-chain ceramide synthase CERS2) (EC 2.3.1.297)	5	UniProt NCBI
SLC35F2	Solute carrier family 35 member F2	3	UniProt NCBI
ATP5PF	ATP synthase-coupling factor 6, mitochondrial (ATPase subunit F6) (ATP synthase peripheral stalk subunit F6)	5	UniProt NCBI
ITPRIPL1	Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1	4	UniProt NCBI
B4GALT3	Beta-1,4-galactosyltransferase 3 (Beta-1,4-GalTase 3) (Beta4Gal-T3) (b4Gal-T3) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase) (EC 2.4.1.38) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (Neolactotriaosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.275) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3)	5	UniProt NCBI
ATP5PB	ATP synthase F(0) complex subunit B1, mitochondrial (ATP synthase peripheral stalk-membrane subunit b) (ATP synthase proton-transporting mitochondrial F(0) complex subunit B1) (ATP synthase subunit b) (ATPase subunit b)	5	UniProt NCBI
SLC6A5	Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5)	5	UniProt NCBI
ATP5F1C	ATP synthase subunit gamma, mitochondrial (ATP synthase F1 subunit gamma) (F-ATPase gamma subunit)	5	UniProt NCBI
RETREG3	Reticulophagy regulator 3	5	UniProt NCBI
CERS6	Ceramide synthase 6 (CerS6) (LAG1 longevity assurance homolog 6) (Sphingoid base N-palmitoyltransferase CERS6) (EC 2.3.1.291)	5	UniProt NCBI
NTSR1	Neurotensin receptor type 1 (NT-R-1) (NTR1) (High-affinity levocabastine-insensitive neurotensin receptor) (NTRH)	5	UniProt NCBI
XYLT2	Xylosyltransferase 2 (EC 2.4.2.26) (Peptide O-xylosyltransferase 1) (Xylosyltransferase II) (XT-II) (XylT-II)	5	UniProt NCBI
MT-ATP6	ATP synthase subunit a (F-ATPase protein 6)	5	UniProt NCBI
KDSR	3-ketodihydrosphingosine reductase (KDS reductase) (EC 1.1.1.102) (3-dehydrosphinganine reductase) (Follicular variant translocation protein 1) (FVT-1) (Short chain dehydrogenase/reductase family 35C member 1)	5	UniProt NCBI
YIF1B	Protein YIF1B (YIP1-interacting factor homolog B)	5	UniProt NCBI
ATP5MC1	ATP synthase F(0) complex subunit C1, mitochondrial (ATP synthase lipid-binding protein) (ATP synthase membrane subunit c locus 1) (ATP synthase proteolipid P1) (ATP synthase proton-transporting mitochondrial F(0) complex subunit C1) (ATPase protein 9) (ATPase subunit c)	5	UniProt NCBI
TMEM120A	Ion channel TACAN (Transmembrane protein 120A) (Transmembrane protein induced by tumor necrosis factor alpha)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:563	2.63442859695e-08	0.235294117647	ATP5PD ATP5MC1 ATP5F1C MT-ATP6	F1F0-ATP synthase, mitochondrial
REAC:R-HSA-163210	1.22405481068e-06	0.235294117647	ATP5PD ATP5MC1 ATP5F1C MT-ATP6	Formation of ATP by chemiosmotic coupling
REAC:R-HSA-8949613	1.08691709251e-05	0.235294117647	ATP5PD ATP5MC1 ATP5F1C MT-ATP6	Cristae formation
KEGG:01100	1.92143703204e-05	0.588235294118	KDSR ATP5F1C XYLT2 MT-ATP6 ATP5PD B4GALT3 CERS6 CERS2 ATP5MC1 POMK	Metabolic pathways
WP:WP5194	0.000142297954317	0.176470588235	CERS2 KDSR CERS6	Synthesis of ceramides and 1 deoxyceramides
WP:WP4725	0.000225662254027	0.176470588235	CERS2 KDSR CERS6	Sphingolipid metabolism overview
WP:WP4726	0.000259325086727	0.176470588235	CERS2 KDSR CERS6	Sphingolipid metabolism integrated pathway
GO:0005753	0.000370294446338	0.235294117647	ATP5PD ATP5MC1 ATP5F1C MT-ATP6	mitochondrial proton-transporting ATP synthase complex
GO:0045259	0.000370294446338	0.235294117647	ATP5PD ATP5MC1 ATP5F1C MT-ATP6	proton-transporting ATP synthase complex
WP:WP1422	0.000427073770653	0.176470588235	CERS2 KDSR CERS6	Sphingolipid pathway
WP:WP111	0.000480800511956	0.235294117647	ATP5PD ATP5MC1 ATP5F1C MT-ATP6	Electron transport chain OXPHOS system in mitochondria
KEGG:00190	0.00060995946936	0.235294117647	ATP5PD ATP5MC1 ATP5F1C MT-ATP6	Oxidative phosphorylation
REAC:R-HSA-1592230	0.000809259204816	0.235294117647	ATP5PD ATP5MC1 ATP5F1C MT-ATP6	Mitochondrial biogenesis
KEGG:00600	0.00123864524934	0.176470588235	CERS2 KDSR CERS6	Sphingolipid metabolism
REAC:R-HSA-1660661	0.00246776537748	0.176470588235	CERS2 KDSR CERS6	Sphingolipid de novo biosynthesis
KEGG:05415	0.00294222112915	0.235294117647	ATP5PD ATP5MC1 ATP5F1C MT-ATP6	Diabetic cardiomyopathy
REAC:R-HSA-163200	0.00315759336166	0.235294117647	ATP5PD ATP5MC1 ATP5F1C MT-ATP6	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
KEGG:05208	0.00441585259625	0.235294117647	ATP5PD ATP5MC1 ATP5F1C MT-ATP6	Chemical carcinogenesis - reactive oxygen species
WP:WP623	0.00463861116098	0.176470588235	ATP5PD ATP5MC1 MT-ATP6	Oxidative phosphorylation
KEGG:04714	0.0046760900483	0.235294117647	ATP5PD ATP5MC1 ATP5F1C MT-ATP6	Thermogenesis
GO:0016469	0.00826243748026	0.235294117647	ATP5PD ATP5MC1 ATP5F1C MT-ATP6	proton-transporting two-sector ATPase complex
KEGG:05012	0.0083309171107	0.235294117647	ATP5PD ATP5MC1 ATP5F1C MT-ATP6	Parkinson disease
KEGG:05020	0.00931508694039	0.235294117647	ATP5PD ATP5MC1 ATP5F1C MT-ATP6	Prion disease
REAC:R-HSA-1428517	0.0117782749684	0.235294117647	ATP5PD ATP5MC1 ATP5F1C MT-ATP6	The citric acid (TCA) cycle and respiratory electron transport
KEGG:05016	0.0137194066298	0.235294117647	ATP5PD ATP5MC1 ATP5F1C MT-ATP6	Huntington disease
GO:1901566	0.0142742646594	0.588235294118	KDSR ATP5F1C XYLT2 MT-ATP6 ATP5PD B4GALT3 CERS6 CERS2 ATP5MC1 POMK	organonitrogen compound biosynthetic process
REAC:R-HSA-1430728	0.0174538515917	0.529411764706	KDSR ATP5F1C B4GALT3 MT-ATP6 ATP5PD XYLT2 CERS6 CERS2 ATP5MC1	Metabolism
KEGG:00515	0.0175018678419	0.117647058824	B4GALT3 POMK	Mannose type O-glycan biosynthesis
REAC:R-HSA-428157	0.0249399389719	0.176470588235	CERS2 KDSR CERS6	Sphingolipid metabolism
KEGG:05014	0.027083672511	0.235294117647	ATP5PD ATP5MC1 ATP5F1C MT-ATP6	Amyotrophic lateral sclerosis
KEGG:05010	0.0324963103185	0.235294117647	ATP5PD ATP5MC1 ATP5F1C MT-ATP6	Alzheimer disease
GO:1901137	0.0326826229337	0.411764705882	ATP5F1C MT-ATP6 ATP5PD B4GALT3 XYLT2 ATP5MC1 POMK	carbohydrate derivative biosynthetic process
GO:0046933	0.0362620408935	0.176470588235	ATP5PD ATP5F1C MT-ATP6	proton-transporting ATP synthase activity, rotational mechanism

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
ATP5PD	ATP5PB	1.0	0.93	structurally_consistent (dimer)
ATP5PB	ATP5PF	1.0	0.908	structurally_consistent (dimer)
ATP5PF	ATP5F1C	1.0	0.856
ATP5PB	MT-ATP6	1.0	0.826	structurally_consistent (dimer)
ATP5PD	ATP5PF	1.0	0.914
ATP5PD	ATP5F1C	0.999	0.886	structurally_consistent (P00846)
ATP5PB	CERS2	0.999	0.07
ATP5PB	ATP5F1C	0.999	0.962	structurally_consistent (P00846)
ATP5PF	MT-ATP6	0.999	0.938	structurally_consistent (P24539)
POMK	SLC35F2	0.999	0.068
CERS2	ATP5F1C	0.999	0.034
CERS2	POMK	0.999	0.114	structurally_consistent (dimer)
ATP5PD	CERS2	0.999	0.152
ATP5PD	RETREG3	0.998	0.08
ATP5PD	KDSR	0.998	0.116
ATP5PF	CERS2	0.998	0.06
KDSR	ATP5F1C	0.997	0.21
ATP5MC1	POMK	0.997
XYLT2	RETREG3	0.996	0.164
CERS2	KDSR	0.996	0.032	structurally_consistent (dimer)
CERS2	RETREG3	0.995	0.018
ATP5PB	SLC6A5	0.995
KDSR	POMK	0.995	0.118
MT-ATP6	RETREG3	0.994	0.058
ATP5PD	B4GALT3	0.994	0.116
ATP5PD	MT-ATP6	0.994	0.84	structurally_consistent (dimer)
XYLT2	POMK	0.994	0.068	structurally_consistent (dimer)
XYLT2	B4GALT3	0.993	0.152
MT-ATP6	ATP5F1C	0.993	0.872	structurally_consistent (dimer)
KDSR	RETREG3	0.993	0.076
ATP5PF	SLC6A5	0.992
ATP5PF	KDSR	0.992	0.082
YIF1B	POMK	0.992	0.12
MT-ATP6	CERS2	0.991	0.054
RETREG3	CERS6	0.991	0.088
ATP5PB	KDSR	0.99	0.154
ATP5PB	B4GALT3	0.99	0.038
B4GALT3	POMK	0.989	0.108	structurally_consistent (dimer)
ATP5PF	CERS6	0.989	0.066
ATP5PB	CERS6	0.988	0.116
POMK	CERS6	0.987	0.18	structurally_consistent (dimer)
RETREG3	SLC35F2	0.985	0.102
ATP5PF	XYLT2	0.984	0.042
ATP5PB	NTSR1	0.984
ATP5PB	RETREG3	0.983	0.104
YIF1B	KDSR	0.983	0.022
ATP5PF	SLC35F2	0.982	0.064
ATP5PB	POMK	0.982	0.186
ATP5PD	SLC6A5	0.981
ATP5PB	SLC35F2	0.981	0.062
ITPRIPL1	RETREG3	0.98
TMEM120A	KDSR	0.979	0.05
ATP5PF	B4GALT3	0.978	0.054
ATP5PD	CERS6	0.978	0.132
ATP5PB	YIF1B	0.978	0.142
ATP5F1C	CERS6	0.976	0.09
ATP5PF	RETREG3	0.975	0.08
ITPRIPL1	SLC35F2	0.975
KDSR	CERS6	0.975	0.094	structurally_consistent (dimer)
RETREG3	POMK	0.975	0.08
KDSR	ITPRIPL1	0.974
ATP5PF	TMEM120A	0.974	0.096
CERS2	ATP5MC1	0.972
ATP5PB	TMEM120A	0.971	0.166
ATP5PB	ATP5MC1	0.966
KDSR	SLC35F2	0.965	0.038
ATP5PF	YIF1B	0.964	0.048
SLC35F2	CERS6	0.964	0.058
KDSR	ATP5MC1	0.963
NTSR1	ATP5F1C	0.96
ATP5PD	SLC35F2	0.959	0.066
ATP5PF	NTSR1	0.959
ITPRIPL1	POMK	0.959
TMEM120A	RETREG3	0.957	0.048
MT-ATP6	KDSR	0.956	0.122
XYLT2	KDSR	0.955	0.044
CERS2	YIF1B	0.955	0.044
ATP5F1C	ATP5MC1	0.954
ATP5PF	ITPRIPL1	0.954
MT-ATP6	CERS6	0.954	0.148
TMEM120A	ATP5MC1	0.953
ATP5PF	ATP5MC1	0.947
B4GALT3	ATP5MC1	0.946
B4GALT3	ATP5F1C	0.943	0.074	structurally_consistent (P25705)
ATP5PD	TMEM120A	0.937	0.06
B4GALT3	KDSR	0.935	0.104
CERS2	TMEM120A	0.934	0.068
TMEM120A	ITPRIPL1	0.93
YIF1B	CERS6	0.93	0.084
YIF1B	RETREG3	0.93	0.058
XYLT2	SLC35F2	0.927	0.078
ATP5PD	ATP5MC1	0.922
CERS2	NTSR1	0.922
ITPRIPL1	CERS6	0.921
XYLT2	TMEM120A	0.92	0.08
XYLT2	CERS6	0.919	0.12	structurally_consistent (Q9H5K3)
B4GALT3	CERS2	0.918	0.08	structurally_consistent (Q9H5K3)
ITPRIPL1	ATP5F1C	0.914
CERS2	CERS6	0.914	0.084	mutually_exclusive (Q06136)
XYLT2	ATP5MC1	0.914
ATP5PD	YIF1B	0.913	0.106
RETREG3	ATP5F1C	0.912	0.15
B4GALT3	YIF1B	0.912	0.058
ITPRIPL1	ATP5MC1	0.905
TMEM120A	CERS6	0.901	0.08	structurally_consistent (Q9H5K3)
SLC6A5	CERS6	0.901		structurally_consistent (dimer)
TMEM120A	POMK	0.899	0.08	structurally_consistent (dimer)
ATP5MC1	SLC35F2	0.896
CERS2	SLC35F2	0.895	0.066
YIF1B	SLC35F2	0.891	0.038
ATP5MC1	CERS6	0.89
ATP5PD	POMK	0.889	0.236
YIF1B	ATP5MC1	0.885
TMEM120A	SLC35F2	0.883	0.03
B4GALT3	NTSR1	0.875
CERS2	ITPRIPL1	0.871
NTSR1	CERS6	0.865
B4GALT3	TMEM120A	0.852	0.052	structurally_consistent (Q9H5K3)
NTSR1	POMK	0.851
YIF1B	TMEM120A	0.849	0.03
XYLT2	ITPRIPL1	0.825
ATP5PD	NTSR1	0.817
B4GALT3	ITPRIPL1	0.8
YIF1B	ITPRIPL1	0.795
ATP5PD	ITPRIPL1	0.795
CERS2	SLC6A5	0.79
YIF1B	ATP5F1C	0.77	0.148
ATP5PB	ITPRIPL1	0.769
TMEM120A	ATP5F1C	0.752	0.124
ATP5PB	XYLT2	0.748	0.082
XYLT2	CERS2	0.707	0.066	structurally_consistent (Q9H5K3)
ATP5PD	XYLT2	0.703	0.114
ATP5PF	POMK	0.661	0.11
RETREG3	ATP5MC1	0.653
MT-ATP6	SLC35F2	0.642	0.06
XYLT2	YIF1B	0.637	0.082
NTSR1	TMEM120A	0.619
YIF1B	NTSR1	0.61
B4GALT3	CERS6	0.596	0.09
MT-ATP6	TMEM120A	0.592	0.08
NTSR1	ITPRIPL1	0.579
MT-ATP6	SLC6A5	0.524
MT-ATP6	XYLT2	0.521	0.038
NTSR1	KDSR	0.483
XYLT2	ATP5F1C	0.433	0.102
MT-ATP6	ITPRIPL1	0.411
NTSR1	SLC35F2	0.393
MT-ATP6	ATP5MC1	0.388
ATP5F1C	SLC35F2	0.355	0.06
MT-ATP6	POMK	0.346	0.134
SLC6A5	RETREG3	0.342
NTSR1	ATP5MC1	0.25
MT-ATP6	NTSR1	0.243
MT-ATP6	YIF1B	0.242	0.088
NTSR1	RETREG3	0.239
SLC6A5	ATP5F1C	0.227
XYLT2	NTSR1	0.203
B4GALT3	RETREG3	0.199	0.076
ATP5F1C	POMK	0.16	0.206
SLC6A5	YIF1B	0.107
B4GALT3	SLC35F2	0.056	0.108
MT-ATP6	B4GALT3	0.027	0.06
XYLT2	SLC6A5	0.021
SLC6A5	KDSR	0.011

Related Complexes

Genename	Complexes
ATP5PD	huMAP3_00060.1 huMAP3_01732.1 huMAP3_05994.1 huMAP3_06247.1 huMAP3_07476.1 huMAP3_08393.1 huMAP3_08716.1 huMAP3_09307.1 huMAP3_09775.1 huMAP3_11095.1
POMK	huMAP3_05994.1 huMAP3_08393.1 huMAP3_09307.1 huMAP3_11095.1
CERS2	huMAP3_01732.1 huMAP3_05994.1 huMAP3_06247.1 huMAP3_08393.1 huMAP3_08547.1 huMAP3_09307.1 huMAP3_11095.1
SLC35F2	huMAP3_05994.1 huMAP3_08393.1 huMAP3_09307.1 huMAP3_09584.1 huMAP3_11095.1
ATP5PF	huMAP3_00060.1 huMAP3_05994.1 huMAP3_07476.1 huMAP3_08393.1 huMAP3_09307.1 huMAP3_09775.1 huMAP3_11095.1
ITPRIPL1	huMAP3_02455.1 huMAP3_05994.1 huMAP3_08393.1 huMAP3_09307.1 huMAP3_11095.1
B4GALT3	huMAP3_01667.1 huMAP3_05994.1 huMAP3_08393.1 huMAP3_09307.1 huMAP3_11040.1 huMAP3_11095.1
ATP5PB	huMAP3_00060.1 huMAP3_01732.1 huMAP3_05994.1 huMAP3_06247.1 huMAP3_07476.1 huMAP3_08393.1 huMAP3_08716.1 huMAP3_09307.1 huMAP3_09775.1 huMAP3_11095.1
SLC6A5	huMAP3_01732.1 huMAP3_05994.1 huMAP3_08393.1 huMAP3_09307.1 huMAP3_09589.1 huMAP3_10245.1 huMAP3_11095.1 huMAP3_11216.1
ATP5F1C	huMAP3_03298.1 huMAP3_05994.1 huMAP3_07476.1 huMAP3_08393.1 huMAP3_08716.1 huMAP3_09307.1 huMAP3_09775.1 huMAP3_11095.1
RETREG3	huMAP3_02455.1 huMAP3_05994.1 huMAP3_07476.1 huMAP3_08393.1 huMAP3_09307.1 huMAP3_09584.1 huMAP3_11095.1
CERS6	huMAP3_05994.1 huMAP3_07476.1 huMAP3_08393.1 huMAP3_09307.1 huMAP3_09775.1 huMAP3_11095.1
NTSR1	huMAP3_01732.1 huMAP3_05994.1 huMAP3_08393.1 huMAP3_08716.1 huMAP3_09307.1 huMAP3_09775.1 huMAP3_11095.1
XYLT2	huMAP3_01667.1 huMAP3_05994.1 huMAP3_07236.1 huMAP3_08393.1 huMAP3_09307.1 huMAP3_11040.1 huMAP3_11095.1
MT-ATP6	huMAP3_00060.1 huMAP3_01732.1 huMAP3_05994.1 huMAP3_07476.1 huMAP3_08393.1 huMAP3_08716.1 huMAP3_09307.1 huMAP3_09775.1 huMAP3_11095.1
KDSR	huMAP3_02455.1 huMAP3_05994.1 huMAP3_07476.1 huMAP3_08393.1 huMAP3_09307.1 huMAP3_11095.1
YIF1B	huMAP3_01732.1 huMAP3_05994.1 huMAP3_07410.1 huMAP3_08393.1 huMAP3_08610.1 huMAP3_09008.1 huMAP3_09307.1 huMAP3_11095.1 huMAP3_13464.1
ATP5MC1	huMAP3_04244.1 huMAP3_08393.1 huMAP3_08716.1 huMAP3_09307.1 huMAP3_09775.1 huMAP3_10274.1 huMAP3_11095.1 huMAP3_13647.1
TMEM120A	huMAP3_01732.1 huMAP3_05994.1 huMAP3_08393.1 huMAP3_09307.1 huMAP3_09775.1 huMAP3_11095.1 huMAP3_13197.1 huMAP3_15312.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_08393.1

Complex Portal: CPX-16227