hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09247.1
Complex Portal: CPX-23621
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TIMM50 | Mitochondrial import inner membrane translocase subunit TIM50 | 5 | UniProt NCBI |
| OXA1L | Mitochondrial inner membrane protein OXA1L (Hsa) (OXA1Hs) (Oxidase assembly 1-like protein) (OXA1-like protein) | 5 | UniProt NCBI |
| COQ8A | Atypical kinase COQ8A, mitochondrial (EC 2.7.-.-) (Chaperone activity of bc1 complex-like) (Chaperone-ABC1-like) (Coenzyme Q protein 8A) (aarF domain-containing protein kinase 3) | 5 | UniProt NCBI |
| AFG3L2 | AFG3-like protein 2 (EC 3.4.24.-) (Paraplegin-like protein) | 5 | UniProt NCBI |
| UNC45A | Protein unc-45 homolog A (Unc-45A) (GCUNC-45) (Smooth muscle cell-associated protein 1) (SMAP-1) | 5 | UniProt NCBI |
| RNF5 | E3 ubiquitin-protein ligase RNF5 (EC 2.3.2.27) (RING finger protein 5) (Ram1 homolog) (HsRma1) | 5 | UniProt NCBI |
| AASS | Alpha-aminoadipic semialdehyde synthase, mitochondrial (LKR/SDH) [Includes: Lysine ketoglutarate reductase (LKR) (LOR) (EC 1.5.1.8); Saccharopine dehydrogenase (SDH) (EC 1.5.1.9)] | 5 | UniProt NCBI |
| GCDH | Glutaryl-CoA dehydrogenase, mitochondrial (GCD) (EC 1.3.8.6) | 5 | UniProt NCBI |
| PYCR1 | Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0002921 | 0.000147123076291 | 0.666666666667 | GCDH TIMM50 AASS COQ8A UNC45A PYCR1 | Abnormal cerebrospinal fluid morphology |
| HP:0004305 | 0.00333259827696 | 0.666666666667 | GCDH TIMM50 AASS AFG3L2 COQ8A PYCR1 | Involuntary movements |
| REAC:R-HSA-71064 | 0.00438093013445 | 0.222222222222 | AASS GCDH | Lysine catabolism |
| KEGG:00310 | 0.027672011875 | 0.222222222222 | AASS GCDH | Lysine degradation |
| HP:0012240 | 0.0414791566521 | 0.222222222222 | COQ8A AFG3L2 | Increased intramyocellular lipid droplets |
| HP:0020219 | 0.0455154719118 | 0.444444444444 | COQ8A GCDH TIMM50 AFG3L2 | Motor seizure |
| HP:0012443 | 0.0474173435295 | 0.777777777778 | GCDH TIMM50 AASS AFG3L2 COQ8A UNC45A PYCR1 | Abnormal brain morphology |
| CORUM:3098 | 0.0499842271994 | 0.111111111111 | TIMM50 | TIM50-SMN1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RNF5 | AFG3L2 | 0.993 | 0.084 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PYCR1 | AFG3L2 | 0.99 | 0.078 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM fraction boldt_WMM | |
| OXA1L | AFG3L2 | 0.979 | 0.232 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| AFG3L2 | COQ8A | 0.976 | 0.088 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| TIMM50 | AFG3L2 | 0.971 | 0.292 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| OXA1L | TIMM50 | 0.967 | 0.384 | hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| AFG3L2 | UNC45A | 0.967 | 0.128 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only | |
| RNF5 | TIMM50 | 0.964 | 0.15 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | |
| AASS | AFG3L2 | 0.962 | 0.02 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| GCDH | AFG3L2 | 0.961 | 0.224 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| RNF5 | GCDH | 0.938 | 0.086 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| PYCR1 | COQ8A | 0.88 | 0.13 | bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM treiber_WMM WMM_only | |
| GCDH | UNC45A | 0.858 | 0.0554 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| PYCR1 | GCDH | 0.85 | 0.064 | bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only | |
| COQ8A | UNC45A | 0.811 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM treiber_WMM | |
| AASS | GCDH | 0.748 | 0.048 | bioplex_WMM bioplex3_WMM boldt fraction boldt_WMM | |
| TIMM50 | GCDH | 0.707 | 0.084 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only | |
| AASS | UNC45A | 0.641 | 0.06 | bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only | |
| OXA1L | PYCR1 | 0.473 | 0.16 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| OXA1L | RNF5 | 0.434 | 0.092 | bioplex_WMM bioplex3_WMM WMM_only | |
| PYCR1 | AASS | 0.426 | 0.07 | bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| GCDH | COQ8A | 0.403 | 0.056 | bioplex_WMM bioplex3_WMM boldt youn_WMM fraction boldt_WMM | |
| AASS | COQ8A | 0.383 | 0.03 | bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| OXA1L | COQ8A | 0.335 | 0.076 | bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| OXA1L | UNC45A | 0.278 | 0.06 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| PYCR1 | UNC45A | 0.208 | 0.1 | bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only | |
| TIMM50 | UNC45A | 0.136 | 0.096 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM | |
| TIMM50 | AASS | 0.111 | 0.0701165048544 | bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only | |
| OXA1L | GCDH | 0.087 | 0.046 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| RNF5 | AASS | 0.085 | 0.042 | bioplex_WMM bioplex3_WMM WMM_only | |
| TIMM50 | COQ8A | 0.075 | 0.13 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM | |
| RNF5 | COQ8A | 0.075 | 0.1 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| OXA1L | AASS | 0.052 | 0.01 | bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| RNF5 | PYCR1 | 0.038 | 0.104 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RNF5 | UNC45A | 0.033 | 0.204 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| TIMM50 | PYCR1 | 0.009 | 0.278 | bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM WMM_only |
Related Complexes