hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10973.1
Complex Portal: CPX-21727
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CCSER1 | Serine-rich coiled-coil domain-containing protein 1 (Coiled-coil serine-rich protein 1) | 3 | UniProt NCBI |
| PDE4B | 3',5'-cyclic-AMP phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) (cAMP-specific phosphodiesterase 4B) | 5 | UniProt NCBI |
| NDE1 | Nuclear distribution protein nudE homolog 1 (NudE) | 5 | UniProt NCBI |
| PAFAH1B3 | Platelet-activating factor acetylhydrolase IB subunit alpha1 (EC 3.1.1.47) (PAF acetylhydrolase 29 kDa subunit) (PAF-AH 29 kDa subunit) (PAF-AH subunit gamma) (PAFAH subunit gamma) | 5 | UniProt NCBI |
| CCSER2 | Serine-rich coiled-coil domain-containing protein 2 (Coiled-coil serine-rich protein 2) (Protein GCAP14 homolog) | 4 | UniProt NCBI |
| DISC1 | Disrupted in schizophrenia 1 protein | 5 | UniProt NCBI |
| NDEL1 | Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1) | 5 | UniProt NCBI |
| PAFAH1B1 | Platelet-activating factor acetylhydrolase IB subunit beta (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) | 5 | UniProt NCBI |
| GRIPAP1 | GRIP1-associated protein 1 (GRASP-1) [Cleaved into: GRASP-1 C-terminal chain (30kDa C-terminus form)] | 5 | UniProt NCBI |
| CALB1 | Calbindin (Calbindin D28) (D-28K) (Vitamin D-dependent calcium-binding protein, avian-type) | 5 | UniProt NCBI |
| PAFAH1B2 | Platelet-activating factor acetylhydrolase IB subunit alpha2 (EC 3.1.1.47) (PAF acetylhydrolase 30 kDa subunit) (PAF-AH 30 kDa subunit) (PAF-AH subunit beta) (PAFAH subunit beta) | 5 | UniProt NCBI |
| DIXDC1 | Dixin (Coiled-coil protein DIX1) (Coiled-coil-DIX1) (DIX domain-containing protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5409 | 6.37387064498e-09 | 0.333333333333 | PAFAH1B2 NDEL1 PAFAH1B3 PAFAH1B1 | PAFAH1B1 copy number variation |
| GO:0008247 | 2.11464090368e-05 | 0.25 | PAFAH1B1 PAFAH1B3 PAFAH1B2 | 1-alkyl-2-acetylglycerophosphocholine esterase complex |
| CORUM:6046 | 3.75927585468e-05 | 0.166666666667 | PDE4B DISC1 | PDE4B-DISC1 complex |
| WP:WP5376 | 5.58837700991e-05 | 0.25 | DISC1 PAFAH1B1 NDEL1 | 17p13 3 YWHAE copy number variation |
| CORUM:7004 | 0.000112726824524 | 0.166666666667 | PDE4B DISC1 | HTT-DISC1-PDE4B complex |
| KEGG:00565 | 0.000168134627057 | 0.25 | PAFAH1B1 PAFAH1B3 PAFAH1B2 | Ether lipid metabolism |
| REAC:R-HSA-6811436 | 0.00220413551192 | 0.25 | PAFAH1B1 PAFAH1B3 PAFAH1B2 | COPI-independent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-141444 | 0.0138503617857 | 0.25 | NDEL1 NDE1 PAFAH1B1 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-141424 | 0.0138503617857 | 0.25 | NDEL1 NDE1 PAFAH1B1 | Amplification of signal from the kinetochores |
| REAC:R-HSA-69618 | 0.0223503721045 | 0.25 | NDEL1 NDE1 PAFAH1B1 | Mitotic Spindle Checkpoint |
| REAC:R-HSA-9648025 | 0.0255731910989 | 0.25 | NDEL1 NDE1 PAFAH1B1 | EML4 and NUDC in mitotic spindle formation |
| REAC:R-HSA-2500257 | 0.0313378649398 | 0.25 | NDEL1 NDE1 PAFAH1B1 | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-8856688 | 0.0353388071054 | 0.25 | PAFAH1B1 PAFAH1B3 PAFAH1B2 | Golgi-to-ER retrograde transport |
| REAC:R-HSA-5663220 | 0.0405630540002 | 0.25 | NDEL1 NDE1 PAFAH1B1 | RHO GTPases Activate Formins |
| CORUM:7235 | 0.0499436884912 | 0.0833333333333 | DISC1 | DISC1-DRD2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PAFAH1B3 | PAFAH1B2 | 1.0 | 0.406 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 boldt_WMM |
| NDEL1 | DISC1 | 1.0 | 0.1 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| NDEL1 | DIXDC1 | 1.0 | 0.094 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| CCSER1 | NDEL1 | 1.0 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NDEL1 | CCSER2 | 1.0 | 0.122 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| NDE1 | NDEL1 | 0.999 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM | |
| CCSER1 | NDE1 | 0.999 |
mutually_exclusive (Q9GZM8)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NDE1 | DISC1 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PAFAH1B1 | PAFAH1B3 | 0.999 | 0.048 |
structurally_consistent (P68402)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 fraction boldt_WMM |
| NDEL1 | GRIPAP1 | 0.998 | 0.12 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PAFAH1B1 | PAFAH1B2 | 0.997 | 0.52 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 fraction boldt_WMM |
| NDEL1 | PAFAH1B1 | 0.996 | 0.266 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| DISC1 | GRIPAP1 | 0.996 | 0.102 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NDE1 | CCSER2 | 0.994 | hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM | ||
| NDE1 | DIXDC1 | 0.991 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | ||
| NDE1 | PAFAH1B1 | 0.985 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM boldt hein () gupta_WMM boldt_WMM | |
| CCSER2 | PAFAH1B1 | 0.982 | 0.0977 | hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM | |
| PDE4B | DISC1 | 0.98 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| DIXDC1 | PAFAH1B1 | 0.961 | 0.1 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| GRIPAP1 | CALB1 | 0.959 | 0.044 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| NDE1 | GRIPAP1 | 0.954 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PAFAH1B1 | DISC1 | 0.927 | 0.142 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CCSER2 | DIXDC1 | 0.902 | 0.108 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| CCSER1 | PAFAH1B1 | 0.893 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CCSER1 | CCSER2 | 0.885 |
mutually_exclusive (Q9GZM8)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| CCSER2 | GRIPAP1 | 0.764 | 0.086 | bioplex_WMM bioplex3_WMM WMM_only | |
| CCSER1 | DIXDC1 | 0.735 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CCSER2 | DISC1 | 0.703 | 0.06 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| CCSER1 | DISC1 | 0.644 |
mutually_exclusive (Q9NXR1)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| DIXDC1 | DISC1 | 0.644 | 0.126 |
mutually_exclusive (Q9GZM8)
|
bioplex_WMM bioplex3_WMM WMM_only |
| PDE4B | GRIPAP1 | 0.633 | bioplex3_WMM WMM_only | ||
| PAFAH1B1 | GRIPAP1 | 0.589 | 0.174 | bioplex_WMM bioplex3_WMM WMM_only | |
| CCSER1 | GRIPAP1 | 0.589 | bioplex_WMM bioplex3_WMM WMM_only | ||
| DIXDC1 | GRIPAP1 | 0.589 | 0.07 | bioplex_WMM bioplex3_WMM WMM_only | |
| NDEL1 | PAFAH1B3 | 0.354 | 0.102 |
mutually_exclusive (P43034)
|
hein_WMM WMM_only boldt_WMM |
| NDEL1 | PDE4B | 0.334 | bioplex3_WMM WMM_only | ||
| CCSER2 | PAFAH1B3 | 0.192 | 0.048 | hein_WMM WMM_only | |
| CCSER2 | PAFAH1B2 | 0.192 | 0.076 | hein_WMM WMM_only | |
| NDE1 | PDE4B | 0.173 | bioplex3_WMM WMM_only | ||
| DIXDC1 | PAFAH1B3 | 0.063 | 0.06 | hein_WMM WMM_only | |
| DIXDC1 | PAFAH1B2 | 0.063 | 0.04 | hein_WMM WMM_only | |
| NDEL1 | PAFAH1B2 | 0.062 | 0.312 |
mutually_exclusive (P43034)
structurally_consistent (dimer) |
hein_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only |
| NDE1 | PAFAH1B2 | 0.056 |
mutually_exclusive (P43034)
|
hein_WMM boldt boldt_WMM WMM_only | |
| NDE1 | PAFAH1B3 | 0.043 |
mutually_exclusive (P43034)
|
hein_WMM WMM_only boldt_WMM | |
| PAFAH1B3 | DISC1 | 0.014 | 0.11 | bioplex3_HCT116 WMM_only | |
| PAFAH1B1 | PDE4B | 0.013 | bioplex3_WMM WMM_only | ||
| PAFAH1B1 | CALB1 | 0.011 | 0.104 | fraction | |
| PAFAH1B2 | DISC1 | 0.002 | 0.1 |
structurally_consistent (Q9GZM8)
|
bioplex3_HCT116 WMM_only |
Related Complexes