hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02607.1
Complex Portal: CPX-12179
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HEG1 | Protein HEG homolog 1 | 5 | UniProt NCBI |
| ITGA3 | Integrin alpha-3 (CD49 antigen-like family member C) (FRP-2) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain] | 5 | UniProt NCBI |
| NECTIN1 | Nectin-1 (Herpes virus entry mediator C) (Herpesvirus entry mediator C) (HveC) (Herpesvirus Ig-like receptor) (HIgR) (Nectin cell adhesion molecule 1) (Poliovirus receptor-related protein 1) (CD antigen CD111) | 5 | UniProt NCBI |
| ITGA1 | Integrin alpha-1 (CD49 antigen-like family member A) (Laminin and collagen receptor) (VLA-1) (CD antigen CD49a) | 5 | UniProt NCBI |
| ITGA2 | Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b) | 5 | UniProt NCBI |
| SDK1 | Protein sidekick-1 | 5 | UniProt NCBI |
| LGALS8 | Galectin-8 (Gal-8) (Po66 carbohydrate-binding protein) (Po66-CBP) (Prostate carcinoma tumor antigen 1) (PCTA-1) | 5 | UniProt NCBI |
| FLT4 | Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4) | 5 | UniProt NCBI |
| PTPRG | Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4541 | 0.000854290239056 | 0.428571428571 | ITGA3 ITGA1 FLT4 | Hippo Merlin signaling dysregulation |
| KEGG:04510 | 0.00287556705452 | 0.428571428571 | ITGA3 ITGA1 FLT4 | Focal adhesion |
| KEGG:04151 | 0.0127794263112 | 0.428571428571 | ITGA3 ITGA1 FLT4 | PI3K-Akt signaling pathway |
| REAC:R-HSA-3000157 | 0.0133002920771 | 0.285714285714 | ITGA3 ITGA1 | Laminin interactions |
| KEGG:04640 | 0.0173334447573 | 0.285714285714 | ITGA3 ITGA1 | Hematopoietic cell lineage |
| WP:WP4172 | 0.0189167579285 | 0.428571428571 | ITGA3 ITGA1 FLT4 | PI3K Akt signaling pathway |
| KEGG:04512 | 0.0223578432711 | 0.285714285714 | ITGA3 ITGA1 | ECM-receptor interaction |
| KEGG:05412 | 0.0230300913808 | 0.285714285714 | ITGA3 ITGA1 | Arrhythmogenic right ventricular cardiomyopathy |
| KEGG:05410 | 0.0287602683365 | 0.285714285714 | ITGA3 ITGA1 | Hypertrophic cardiomyopathy |
| KEGG:05414 | 0.0287602683365 | 0.285714285714 | ITGA3 ITGA1 | Dilated cardiomyopathy |
| WP:WP2118 | 0.0300823189809 | 0.285714285714 | ITGA3 ITGA1 | Arrhythmogenic right ventricular cardiomyopathy |
| KEGG:04520 | 0.0367995848147 | 0.285714285714 | HEG1 NECTIN1 | Adherens junction |
| REAC:R-HSA-421270 | 0.037359797124 | 0.285714285714 | SDK1 NECTIN1 | Cell-cell junction organization |
| WP:WP5087 | 0.0480568023702 | 0.428571428571 | ITGA3 ITGA1 FLT4 | Pleural mesothelioma |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| HEG1 | LGALS8 | 0.999 | 0.048 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LGALS8 | PTPRG | 0.997 | 0.048 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ITGA1 | LGALS8 | 0.994 | 0.058 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NECTIN1 | LGALS8 | 0.991 | 0.054 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ITGA3 | LGALS8 | 0.989 | 0.044 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LGALS8 | FLT4 | 0.978 | 0.048 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ITGA3 | ITGA2 | 0.967 | 0.55 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| HEG1 | ITGA1 | 0.967 | 0.074 | bioplex_WMM bioplex3_WMM WMM_only | |
| LGALS8 | SDK1 | 0.959 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ITGA2 | LGALS8 | 0.956 | 0.032 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NECTIN1 | ITGA1 | 0.955 | 0.056 | bioplex_WMM bioplex3_WMM WMM_only | |
| HEG1 | NECTIN1 | 0.954 | 0.052 | bioplex_WMM bioplex3_WMM WMM_only | |
| NECTIN1 | PTPRG | 0.932 | 0.088 | bioplex_WMM bioplex3_WMM WMM_only | |
| HEG1 | ITGA2 | 0.927 | 0.086 | bioplex_WMM bioplex3_WMM WMM_only | |
| ITGA1 | ITGA2 | 0.923 | 0.196 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| ITGA3 | ITGA1 | 0.917 | 0.226 |
mutually_exclusive (P05556)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| ITGA1 | PTPRG | 0.899 | 0.156 | bioplex_WMM bioplex3_WMM WMM_only | |
| HEG1 | PTPRG | 0.895 | 0.108 | bioplex_WMM bioplex3_WMM WMM_only | |
| ITGA1 | SDK1 | 0.832 | bioplex_WMM bioplex3_WMM WMM_only | ||
| HEG1 | ITGA3 | 0.82 | 0.106 | bioplex_WMM bioplex3_WMM WMM_only | |
| ITGA3 | PTPRG | 0.783 | 0.144 | bioplex_WMM bioplex3_WMM WMM_only | |
| ITGA2 | PTPRG | 0.698 | 0.108 | bioplex_WMM bioplex3_WMM WMM_only | |
| HEG1 | SDK1 | 0.619 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ITGA2 | SDK1 | 0.583 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SDK1 | FLT4 | 0.566 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ITGA3 | NECTIN1 | 0.457 | 0.062 | bioplex_WMM bioplex3_WMM WMM_only | |
| HEG1 | FLT4 | 0.447 | 0.1 | bioplex_WMM bioplex3_WMM WMM_only | |
| NECTIN1 | ITGA2 | 0.412 | 0.112 | bioplex_WMM bioplex3_WMM WMM_only | |
| NECTIN1 | SDK1 | 0.401 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ITGA1 | FLT4 | 0.366 | 0.128583333333 | bioplex_WMM bioplex3_WMM WMM_only | |
| ITGA3 | SDK1 | 0.261 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NECTIN1 | FLT4 | 0.255 | 0.108 | bioplex_WMM bioplex3_WMM WMM_only | |
| PTPRG | SDK1 | 0.198 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ITGA2 | FLT4 | 0.171 | 0.098 | bioplex_WMM bioplex3_WMM WMM_only | |
| ITGA3 | FLT4 | 0.161 | 0.076 | bioplex_WMM bioplex3_WMM WMM_only | |
| PTPRG | FLT4 | 0.101 | 0.146 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes