hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10207.1
Complex Portal: CPX-24042
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| G3BP2 | Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2) | 5 | UniProt NCBI |
| NUFIP2 | FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) | 5 | UniProt NCBI |
| CAPRIN1 | Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105) | 5 | UniProt NCBI |
| LSM12 | Protein LSM12 | 5 | UniProt NCBI |
| ATXN2 | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | 5 | UniProt NCBI |
| MCRIP1 | Mapk-regulated corepressor-interacting protein 1 (Granulin-2) (Protein FAM195B) | 5 | UniProt NCBI |
| MCRIP2 | MAPK regulated corepressor interacting protein 2 (Protein FAM195A) | 4 | UniProt NCBI |
| DDX6 | Probable ATP-dependent RNA helicase DDX6 (EC 3.6.4.13) (ATP-dependent RNA helicase p54) (DEAD box protein 6) (Oncogene RCK) | 5 | UniProt NCBI |
| ATXN2L | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0010494 | 1.82993551024e-13 | 0.888888888889 | NUFIP2 DDX6 MCRIP2 ATXN2L CAPRIN1 G3BP2 MCRIP1 ATXN2 | cytoplasmic stress granule |
| GO:0036464 | 6.29010417136e-10 | 0.888888888889 | NUFIP2 DDX6 MCRIP2 ATXN2L CAPRIN1 G3BP2 MCRIP1 ATXN2 | cytoplasmic ribonucleoprotein granule |
| GO:0035770 | 1.19395760835e-09 | 0.888888888889 | NUFIP2 DDX6 MCRIP2 ATXN2L CAPRIN1 G3BP2 MCRIP1 ATXN2 | ribonucleoprotein granule |
| GO:0034063 | 7.42739671679e-08 | 0.555555555556 | ATXN2 DDX6 ATXN2L G3BP2 CAPRIN1 | stress granule assembly |
| GO:0099080 | 6.64269494283e-05 | 0.888888888889 | NUFIP2 DDX6 MCRIP2 ATXN2L CAPRIN1 G3BP2 MCRIP1 ATXN2 | supramolecular complex |
| GO:0003729 | 0.013473555316 | 0.555555555556 | ATXN2 DDX6 ATXN2L G3BP2 CAPRIN1 | mRNA binding |
| HPA:0220053 | 0.0178068828596 | 0.777777777778 | DDX6 ATXN2L CAPRIN1 LSM12 MCRIP1 G3BP2 ATXN2 | gallbladder; glandular cells[High] |
| GO:0140694 | 0.0244291184923 | 0.555555555556 | ATXN2 DDX6 ATXN2L G3BP2 CAPRIN1 | non-membrane-bounded organelle assembly |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CAPRIN1 | G3BP2 | 1.0 | 0.212 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM | |
| LSM12 | ATXN2L | 1.0 | 0.514 |
structurally_consistent (dimer)
|
youn () bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| NUFIP2 | ATXN2L | 1.0 | 0.598 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM | |
| NUFIP2 | LSM12 | 1.0 | 0.272 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| MCRIP2 | LSM12 | 1.0 | 0.146 |
structurally_consistent (dimer)
|
youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| MCRIP2 | ATXN2L | 0.999 | 0.09 |
mutually_exclusive (Q3MHD2)
|
youn () bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| LSM12 | DDX6 | 0.999 | 0.114 |
structurally_consistent (dimer)
|
youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| ATXN2L | DDX6 | 0.998 | 0.334 |
structurally_consistent (dimer)
|
youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM |
| MCRIP2 | DDX6 | 0.998 | 0.122 | youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| ATXN2 | MCRIP2 | 0.998 | 0.092 |
mutually_exclusive (Q3MHD2)
|
youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| NUFIP2 | G3BP2 | 0.997 | 0.098 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM | |
| ATXN2 | LSM12 | 0.996 | 0.216 |
structurally_consistent (dimer)
|
youn () bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM gupta_WMM fraction |
| NUFIP2 | ATXN2 | 0.994 | 0.178 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM treiber_WMM | |
| NUFIP2 | DDX6 | 0.991 | 0.194 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM | |
| ATXN2L | G3BP2 | 0.99 | 0.184 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM | |
| LSM12 | G3BP2 | 0.989 | 0.132 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction | |
| ATXN2 | DDX6 | 0.986 | 0.31 |
structurally_consistent (dimer)
|
youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM treiber_WMM |
| MCRIP1 | LSM12 | 0.968 | 0.03 | youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM | |
| DDX6 | G3BP2 | 0.959 | 0.232 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM | |
| ATXN2 | ATXN2L | 0.92 | 0.54 | youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM | |
| LSM12 | CAPRIN1 | 0.873 | 0.22 | youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| ATXN2 | G3BP2 | 0.852 | 0.154 | hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM | |
| ATXN2 | MCRIP1 | 0.319 | 0.032 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction | |
| MCRIP2 | MCRIP1 | 0.228 | 0.026 | youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| ATXN2L | CAPRIN1 | 0.223 | 0.342 | youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM | |
| MCRIP1 | DDX6 | 0.128 | 0.104 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM | |
| DDX6 | CAPRIN1 | 0.092 | 0.67 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM | |
| MCRIP1 | ATXN2L | 0.081 | 0.016 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM | |
| NUFIP2 | CAPRIN1 | 0.08 | 0.312 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM | |
| NUFIP2 | MCRIP2 | 0.049 | 0.088 | youn () bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| MCRIP2 | G3BP2 | 0.023 | 0.118 | youn () bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| MCRIP1 | G3BP2 | 0.019 | 0.04 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| ATXN2 | CAPRIN1 | 0.015 | 0.2 | youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM treiber_WMM WMM_only | |
| NUFIP2 | MCRIP1 | 0.012 | 0.018 | youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| MCRIP1 | CAPRIN1 | 0.006 | 0.032 | youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| MCRIP2 | CAPRIN1 | 0.002 | 0.108 | youn () bioplex3_HEK293 youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
Related Complexes